This paper investigates the impact of independent and dependent losses and coding on speech quality predictions provided by PESQ (also known as ITU-T P.862) and P.563 models, when both naturally-produced and synthesized speech are used. Two synthesized speech samples generated with
two different Text-to-Speech systems and one naturally-produced sample are investigated. In addition, we assess the variability of PESQ's and P.563's predictions with respect to the type of speech used (naturally-produced or synthesized) and loss conditions as well as their accuracy, by comparing
the predictions with subjective assessments. The results show that there is no difference between the impact of packet loss on naturally-produced speech and synthesized speech. On the other hand, the impact of coding is different for the two types of stimuli. In addition, synthesized speech
seems to be insensitive to degradations provided by most of the codecs investigated here. The reasons for those findings are particularly discussed. Finally, it is concluded that both models are capable of predicting the quality of transmitted synthesized speech under the investigated conditions
to a certain degree. As expected, PESQ achieves the best performance over almost all of the investigated conditions.