scholarly journals Comparative Study of Etomidate versus Propofol as Induction Agent on Hemodynamic Parameters during Endotracheal Intubation Using Entropy Guided Hypnosis Levels in General Anaesthesia

2020 ◽  
Vol 08 (03) ◽  
Author(s):  
Dr Mukesh Kumar ◽  
Keyword(s):  
Comparative Study ◽  
General Anaesthesia ◽  
Endotracheal Intubation ◽  
Induction Agent ◽  
Hemodynamic Parameters

scholarly journals Objective Evaluation of the Difficulty of Endotracheal Intubation. A Comparative Study of Two Different Laryngoscope Blades

1997 ◽  
Vol 25 (6) ◽  
pp. 655-658 ◽  
Author(s):  
E. Papageorgiou ◽  
K. Kokkinis ◽  
P. Goumas ◽  
G. Mochloulis ◽  
C. Alexopoulos
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Statistical Analysis ◽  
Comparative Study ◽  
Light Beam ◽  
General Anaesthesia ◽  
Endotracheal Intubation ◽  
Objective Evaluation ◽  
Laryngoscope Blade ◽  
Laryngoscope Blades

A method for objective evaluation of the difficulty of endotracheal intubation is described. Our data indicate that the angle formed by the light-beam axis of the laryngoscope blade and the laryngotracheal axis, which we call “angle ϕ”, is analogous to the degree of difficulty of endotracheal intubation. Using this method, we compared the effectiveness of a standard Macintosh and a modified bevelled Macintosh blade in 27 tracheostomized Intensive Care Unit patients under general anaesthesia. Statistical analysis of our results indicate that the bevelled blade significantly facilitates endotracheal intubation.

scholarly journals Intravenous dexmedetomidine 1µg/kg as premedication to attenuate hemodynamic response to laryngoscopy and endotracheal intubation in surgeries under general anesthesia

2017 ◽  
Vol 4 (6) ◽  
pp. 1884
Author(s):  
Dixitkumar B. Modh ◽  
Pratiti Gohil ◽  
Manthan Parmar
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Endotracheal Intubation ◽  
Normal Saline ◽  
Induction Agent ◽  
Hemodynamic Parameters ◽  
Hemodynamic Changes ◽  
Dose Requirement ◽  
Hemodynamic Stability ◽  
Induction Dose

Background: Choice of premedication and hemodynamic stability are always remain important concerns during laryngoscopy and endotracheal intubation for Anesthesiologists. Dexmedetomidine offers anxiolytic, sedation, hypnosis, analgesia, antisialagogue action as well as sympatholysis which make most suitable drug as premedication. Our aims for this study to evaluate efficacy of Injection Dexmedetomidine 1µg/kg intravenously as premedication on attenuation of hemodynamic changes to laryngoscopy and intubation as well as requirement of injection Propofol as an induction agent.Methods: In Present study, 60 patients of ASA I, II of age 18 to 45 years were randomly divided in to two groups of 30 each. In group NS, 10 ml normal saline and in group D1 injection Dexmedetomidine 1µg/kg diluted in 10 ml of normal saline was used. In both groups study solutions administered over 10 minutes. Both the groups were administered standard general anaesthesia and requirement of Propofol was noted as an induction agent. Heart rate, blood pressure (systolic, diastolic and mean arterial pressure) were compared at baseline, 2 min, 5 min, 10 minutes (SD2, SD5, SD10) after study drugs administration, before induction (BI), after induction (AI), 1 minute (T1), 2 minutes (T2), 5 minutes (T5) and 10 minutes (T10) after laryngoscopy and intubation in both groups.Results: HR, SBP, DBP and MAP highly significantly reduced at 2 min, 5 min and 10 minutes after infusion of Dexmedetomidine in group D1 as compared to group NS. (P<0.01). After induction values are highly significant in group D1 than group NS from baseline (P<0.01). Highly significant mean rise in hemodynamic parameters (HR, SBP, DBP and MAP) from baseline were observed in group NS compared to group D1 after laryngoscopy and intubation (P<0.01). Induction dose requirement of inj. Propofol significantly reduced in group D1 compared to other group (P<0.01).Conclusions: Injection Dexmedetomidine 1µg/kg provides effective and complete attenuation of pressure response to laryngoscopy and endotracheal intubation as premedication with decreased requirement of inj. Propofol for induction without any side effects.

scholarly journals EVALUATION OF HAEMODYNAMIC STABILITY FOLLOWING INDUCTION OF GENERAL ANAESTHESIA WITH PROPOFOL AND ETOMIDATE IN NORMOTENSIVE AND HYPERTENSIVE PATIENTS: A COMPARATIVE STUDY

2020 ◽  
pp. 117-122
Author(s):  
Ann Mary Alappat ◽  
Jui Yeshavant Lagoo ◽  
Vikram Shivappagoudar
Keyword(s):  
Blood Pressure ◽  
Comparative Study ◽  
General Anaesthesia ◽  
Elective Surgery ◽  
Induction Agent ◽  
Hypertensive Patients ◽  
Haemodynamic Stability ◽  
Prospective Comparative Study ◽  
Post Intubation ◽  
Induction Of Anaesthesia

Background: Induction of anaesthesia and endotracheal intubation are associated with adverse haemodynamic effects which are detrimental in hypertensive patients. Although etomidate is found to be a cardio stable induction agent, its advantages in hypertensive patients are not yet investigated. Aim of the present study is to compare the haemodynamic parameters following induction of anaesthesia with etomidate and propofol in normotensive and hypertensive patients. Methods: In a prospective comparative study, 120 patients aged 18 to 60 years, of both sex and ASA status I & II posted for elective surgery under general anaesthesia were divided into 4 groups of 30 each. Anaesthesia was induced with either propofol or etomidate. Heart rate(HR), Systolic Blood Pressure(SBP), Diastolic Blood Pressure(DBP), Mean Arterial Pressure(MAP) and SpO2 were noted down at baseline, pre-induction, after induction, at laryngoscopy and 1, 3 & 5 minutes post intubation. Results: There was a significant fall in HR after induction with propofol which was more in the hypertensive group. After intubation, a rise in HR was observed in all 4 groups which returned to baseline by 5 minutes. A fall in MAP, SBP and DBP were observed in all the groups following induction, which shooted up after intubation. The fall in MAP with propofol was significantly higher when compared to etomidate which offered stable haemodynamic conditions. Conclusion: The present study suggests that induction of anaesthesia with etomidate is associated with better stability of MAP in normotensive as well as hypertensive patients when compared with propofol. However, HR is better maintained with propofol. Thus there is no clear evidence supporting induction by etomidate in hypertensive patients.

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