Introduction. Chondrolipomas and osteolipomas are uncommon variants of
lipomatous tumors. Case report. We presented a 60-year-old woman with
ossifying chondrolipoma of the tongue. Clinical examination revealed a firm
nodular mass, located in the midline of the posterior region on the dorsal
surface of the tongue. Histologically, the lesion was well-delimited showing
areas of mature adipocytes arranged in lobules and separated by fibrous
connective tissue septa, islands of mature cartilaginous tissue and osseous
metaplasia. Trabeculae of lamellar bone within a fibro-fatty background were
visible throughout the tumor. The cartilaginous areas merging centrally with
bone formation and fatty marrow tissue were present, as well as the
hematopoietic elements in the fatty marrow. The bone forming was found to be
through both membranous and enchondral mechanisms. Conclusion. Ossifying
chrondrolipoma with hematopoietic elements is extremely unusual lesion. This
interesting entity should be kept in mind in the differential diagnosis of
lingual lesions.