scholarly journals Cerebral venous sinus thrombosis and subdural hematoma in a female patient with systemic lupus erythematosus: a case report and literature review

2021 ◽  
Vol 10 (13) ◽  
pp. 6-6
Author(s):  
Jiaai Li ◽  
Hongmei Meng ◽  
Wei Jiang ◽  
Jiaxin Liu ◽  
Zhitao Cui ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Literature Review ◽  
Female Patient ◽  
Subdural Hematoma ◽  
Lupus Erythematosus ◽  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Systemic Lupus ◽  
Venous Sinus Thrombosis

scholarly journals A Lady with Systemic Lupus Erythematosus Complicated with Central Venous Sinus Thrombosis: A Case Report

2020 ◽  
Vol 20 (01) ◽  
pp. 42-46
Author(s):  
Alexandra Hoi Yan Ng ◽  
Daniel Kam Hung Ng
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antiphospholipid Antibodies ◽  
Sinus Thrombosis ◽  
Rare Condition ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Systemic Lupus ◽  
Venous Sinus Thrombosis ◽  
Increased Risk

Systemic lupus erythematosus (SLE) is associated with an increased risk of venous thromboses and cerebrovascular diseases. Herein, we discuss the case of a young 38-year-old Asian lady who was presented with cerebral venous sinus thrombosis (CVST) shortly after she was diagnosed with SLE. She developed headache, right hemiparesis and sustained an episode of seizure on the first presentation. CVST was diagnosed with plain computed tomography (CT) of the brain and CT venogram. With prompt administration of anticoagulation and immunosuppressant treatment for SLE, she had an excellent neurological recovery. There are many different risk factors for developing CVST in SLE patients. It has been reported in literature that CVST is usually associated with antiphospholipid antibodies but only around 40% of them would have positive antiphospholipid antibodies indicating that there are also other mechanisms contributing to the process [1]. As CVST in SLE is a rare condition, no standardized treatment strategy has been delineated. The main cornerstone of treatment would be anticoagulation and appropriate treatment for SLE as these patients are commonly associated with underlying active SLE. With timely management, the prognosis for CVST in SLE patients is generally favourable.

scholarly journals Clinical Characteristics of Cerebral Venous Sinus Thrombosis in Patients with Systemic Lupus Erythematosus: A Single-Centre Experience in China

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Li Wang ◽  
Hua Chen ◽  
Yao Zhang ◽  
Wanli Liu ◽  
Wenjie Zheng ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Clinical Characteristics ◽  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Clinical Feature ◽  
Systemic Lupus ◽  
Single Centre ◽  
Venous Sinus Thrombosis

Clinical characteristics of systemic lupus erythematosus (SLE) patients complicated with cerebral venous sinus thrombosis (CVST) between 2000 and 2013 were analyzed through this retrospective, single-centre study. Of 4747 hospitalized SLE patients, 17 (0.36%, 12 females, average age 30) had CVST. Headache (88.2%) was the most common neurological symptom followed by nausea or vomiting (47.1%), conscious disturbance (41.2%), edema of eyelids or conjunctiva (35.3%), blurred vision or diplopia (35.3%), and seizure (35.3%). Increased intracranial pressure (ICP) occurred in 13 cases (76.5%). Magnetic resonance venography (MRV) detected thrombosis in the transverse (82.4%), sigmoid (52.9%), and sagittal (35.3%) sinuses, with frequent (70.6%) multiple sinus occlusions. Compared to SLE patients without CVST, SLE patients with CVST had a higher prevalence of thrombocytopenia and positive antiphospholipid antibodies and a higher SLE disease activity index (SLEDAI) score. 13 patients achieved improvement following glucocorticoids and immunosuppressants treatment, as well as anticoagulants, while 3 patients died at the hospital. CVST is relatively rare in SLE and tends to occur in active lupus patients. Intracranial hypertension is common but nonspecific clinical feature, so MRV evaluation is necessary to establish a diagnosis. Aggressive treatment for the rapid control of SLE activity combined with anticoagulants can improve the prognosis.

Cerebral venous sinus thrombosis as the initial presentation of systemic lupus erythematosus

Lupus ◽  
2020 ◽  
Vol 29 (2) ◽  
pp. 213-215 ◽  
Author(s):  
T Chandra ◽  
J S Tilstra
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Sinus Thrombosis ◽  
Treatment Strategies ◽  
Signs And Symptoms ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Initial Presentation ◽  
Systemic Lupus ◽  
Venous Sinus Thrombosis

Systemic lupus erythematosus (SLE) is a hypercoagulable state due to a variety of mechanisms. Herein, we discuss the case of a 40-year-old gentleman who presented with cerebral venous sinus thrombosis (CVST) as the first manifestation of underlying SLE. On initial presentation, he did not endorse any other signs and symptoms to suggest the presence of an autoimmune condition. Work-up revealed an absence of antiphospholipid antibodies. Further evaluation uncovered the underlying etiology of the CVST as SLE-induced nephrotic syndrome. The existing literature on CVST suggests that there are only two other biopsy-proven cases of lupus nephritis leading to nephrotic range proteinuria as the etiology for CVST. Given the rarity of this presentation, there are no clearly delineated treatment strategies.

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