The Effect of Smoking on Progression from Ductal Carcinoma in Situ to Invasive Ductal Carcinoma: A Retrospective Study

Abstract Background: If ductal carcinoma in situ (DCIS) is diagnosed by histological examination such as core needle biopsy or vacuum-assisted biopsy (VAB), invasion is often found by removing the entire tumor and performing pathological examination. According to a meta-analysis, the rate of invasion found by postoperative pathological examination is about 25%. Smoking is a risk factor for carcinogenesis in various carcinomas, including breast cancer. We examined the correlation between the risk of invasion found by postoperative pathology and smoking history in patients who were diagnosed with DCIS by preoperative biopsy.Methods: In this study, we examined 128 patients who were diagnosed with DCIS by preoperative biopsy. Before the biopsy, all patients were asked about the duration of smoking, number of cigarettes smoked per day, and whether they were currently smoking. The data were used to calculate each patient’s tobacco exposure based on pack-years. The statistical analyses included the Pearson’s chi-square test and logistic analysis. Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy.Results: Of all the patients included in this study, 107 (83.5%) never smoked, which represented the majority, while 8 patients (6.3%) smoked at diagnosis with DCIS, and 13 (10.2%) had quit smoking before diagnosis. Tobacco exposure was 10 or less pack-years for 11 patients (8.6%) and more than 10 pack-years for 10 patients (7.8%). Number of pack-years was not an independent factor (p=0.349, odds ratio [OR]=0.329), but current smoker status (p=0.006, OR=not calculable) was an independent factor with VAB (p=0.018, OR=0.327).Conclusions: This study suggests that tobacco components may have an influence on the progression from DCIS to invasive ductal carcinoma.

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The Effect of Smoking on Progression From Ductal Carcinoma in Situ to Invasive Ductal Carcinoma: A Retrospective Study

10.21203/rs.3.rs-46065/v1 ◽

2020 ◽

Author(s):

Koji Takada ◽

Shinichiro Kashiwagi ◽

Yuka Asano ◽

Wataru Goto ◽

Rika Kouhashi ◽

...

Keyword(s):

Invasive Ductal Carcinoma ◽

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Smoking History ◽

Pathological Examination ◽

Independent Factor ◽

Tobacco Exposure ◽

Preoperative Biopsy

Abstract Background: If ductal carcinoma in situ (DCIS) is diagnosed by histological examination such as core needle biopsy or vacuum-assisted biopsy (VAB), invasion is often found by removing the entire tumor and performing pathological examination. According to a meta-analysis, the rate of invasion found by postoperative pathological examination is about 25%. Smoking is a risk factor for carcinogenesis in various carcinomas, including breast cancer. We examined the correlation between the risk of invasion found by postoperative pathology and smoking history in patients who were diagnosed with DCIS by preoperative biopsy.Methods: In this study, we examined 128 patients who were diagnosed with DCIS by preoperative biopsy. Before the biopsy, all patients were asked about the duration of smoking, number of cigarettes smoked per day, and whether they were currently smoking. The data were used to calculate each patient’s tobacco exposure based on pack-years. The statistical analyses included the Pearson’s chi-square test and logistic analysis. Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy.Results: Of all the patients included in this study, 107 (83.5%) never smoked, which represented the majority, while 8 patients (6.3%) smoked at diagnosis with DCIS, and 13 (10.2%) had quit smoking before diagnosis. Tobacco exposure was 10 or less pack-years for 11 patients (8.6%) and more than 10 pack-years for 10 patients (7.8%). Number of pack-years was not an independent factor (p=0.349, odds ratio [OR]=0.329), but current smoker status (p=0.006, OR=not calculable) was an independent factor with VAB (p=0.018, OR=0.327).Conclusions: This study suggests that tobacco components may have an influence on the progression from DCIS to invasive ductal carcinoma.

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The Effect of Smoking on Progression from Ductal Carcinoma In Situ to Invasive Ductal Carcinoma: A Retrospective Study

10.21203/rs.3.rs-150875/v1 ◽

2021 ◽

Author(s):

Koji Takada ◽

Shinichiro Kashiwagi ◽

Yuka Asano ◽

Wataru Goto ◽

Rika Kouhashi ◽

...

Keyword(s):

Invasive Ductal Carcinoma ◽

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Smoking History ◽

Pathological Examination ◽

Independent Factor ◽

Tobacco Exposure ◽

Preoperative Biopsy

Abstract Background: If ductal carcinoma in situ (DCIS) is diagnosed by histological examination such as core needle biopsy or vacuum-assisted biopsy (VAB), invasion is often found by removing the entire tumor and performing pathological examination. According to a meta-analysis, the rate of invasion found by postoperative pathological examination is about 25%. Smoking is a risk factor for carcinogenesis in various carcinomas, including breast cancer. We examined the correlation between the risk of invasion found by postoperative pathology and smoking history in patients who were diagnosed with DCIS by preoperative biopsy.Methods: In this study, we examined 128 patients who were diagnosed with DCIS by preoperative biopsy. Before the biopsy, all patients were asked about the duration of smoking, number of cigarettes smoked per day, and whether they were currently smoking. The data were used to calculate each patient’s tobacco exposure based on pack-years. The statistical analyses included the Pearson’s chi-square test and logistic analysis. Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy.Results: Of all the patients included in this study, 107 (83.5%) never smoked, which represented the majority, while 8 patients (6.3%) smoked at diagnosis with DCIS, and 13 (10.2%) had quit smoking before diagnosis. Tobacco exposure was 10 or less pack-years for 11 patients (8.6%) and more than 10 pack-years for 10 patients (7.8%). Number of pack-years was not an independent factor (p=0.349, odds ratio [OR]=0.329), but current smoker status (p=0.006, OR=not calculable) was an independent factor with VAB (p=0.018, OR=0.327).Conclusions: This study suggests that tobacco components may have an influence on the progression from DCIS to invasive ductal carcinoma.

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The Effect of Smoking on Progression from Ductal Carcinoma In Situ to Invasive Ductal Carcinoma: A Retrospective Study

10.21203/rs.3.rs-37789/v3 ◽

2021 ◽

Author(s):

Koji Takada ◽

Shinichiro Kashiwagi ◽

Yuka Asano ◽

Wataru Goto ◽

Rika Kouhashi ◽

...

Keyword(s):

Invasive Ductal Carcinoma ◽

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Smoking History ◽

Pathological Examination ◽

Independent Factor ◽

Tobacco Exposure ◽

Preoperative Biopsy

Abstract Background: If ductal carcinoma in situ (DCIS) is diagnosed by histological examination such as core needle biopsy or vacuum-assisted biopsy (VAB), invasion is often found by removing the entire tumor and performing pathological examination. According to a meta-analysis, the rate of invasion found by postoperative pathological examination is about 25%. Smoking is a risk factor for carcinogenesis in various carcinomas, including breast cancer. We examined the correlation between the risk of invasion found by postoperative pathology and smoking history in patients who were diagnosed with DCIS by preoperative biopsy.Methods: In this study, we examined 128 patients who were diagnosed with DCIS by preoperative biopsy. Before the biopsy, all patients were asked about the duration of smoking, number of cigarettes smoked per day, and whether they were currently smoking. The data were used to calculate each patient’s tobacco exposure based on pack-years. The statistical analyses included the Pearson’s chi-square test and logistic analysis. Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy.Results: Of all the patients included in this study, 107 (83.5%) never smoked, which represented the majority, while 8 patients (6.3%) smoked at diagnosis with DCIS, and 13 (10.2%) had quit smoking before diagnosis. Tobacco exposure was 10 or less pack-years for 11 patients (8.6%) and more than 10 pack-years for 10 patients (7.8%). Number of pack-years was not an independent factor (p=0.349, odds ratio [OR]=0.329), but current smoker status (p=0.006, OR=not calculable) was an independent factor with VAB (p=0.018, OR=0.327).Conclusions: This study suggests that tobacco components may have an influence on the progression from DCIS to invasive ductal carcinoma.

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The Effect of Smoking on Progression From Ductal Carcinoma in Situ to Invasive Ductal Carcinoma: A Retrospective Study

10.21203/rs.3.rs-37789/v1 ◽

2020 ◽

Author(s):

Koji Takada ◽

Shinichiro Kashiwagi ◽

Yuka Asano ◽

Wataru Goto ◽

Rika Kouhashi ◽

...

Keyword(s):

Invasive Ductal Carcinoma ◽

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Smoking History ◽

Pathological Examination ◽

Independent Factor ◽

Tobacco Exposure ◽

Preoperative Biopsy

Abstract Background:If ductal carcinoma in situ (DCIS) is diagnosed by histological examination such as core needle biopsy or vacuum-assisted biopsy (VAB), invasion is often found by removing the entire tumor and performing pathological examination. According to a meta-analysis, the rate of invasion found by postoperative pathological examination is about 25%. Smoking is a risk factor for carcinogenesis in various carcinomas, including breast cancer. We examined the correlation between the risk of invasion found by postoperative pathology and smoking history in patients who were diagnosed with DCIS by preoperative biopsy.Methods:In this study, we examined 128 patients who were diagnosed with DCIS by preoperative biopsy. Before the biopsy, all patients were asked about the duration of smoking, number of cigarettes smoked per day, and whether they were currently smoking. The data were used to calculate each patient’s tobacco exposure based on pack-years. The statistical analyses included the Pearson’s chi-square test and logistic analysis. Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy.Results: Of all the patients included in this study, 107 (83.5%)neversmoked, which represented the majority, while8 patients (6.3%) smoked at diagnosis with DCIS, and 13 (10.2%) had quit smokingbefore diagnosis.Tobacco exposure was 10 or less pack-years for11 patients (8.6%) and more than 10 pack-years for10 patients (7.8%). Number of pack-years was not an independent factor (p=0.349, odds ratio [OR]=0.329), but current smoker status (p=0.006, OR=not calculable) was an independent factor with VAB (p=0.018, OR=0.327).Conclusions: This study suggests that tobacco components may have an influence on the progression from DCIS to invasive ductal carcinoma.

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Clinicopathological predictors of postoperative upstaging to invasive ductal carcinoma (IDC) in patients preoperatively diagnosed with ductal carcinoma in situ (DCIS): a multi-institutional retrospective cohort study

Breast Cancer ◽

10.1007/s12282-021-01225-0 ◽

2021 ◽

Author(s):

Kiyo Tanaka ◽

Norikazu Masuda ◽

Naoki Hayashi ◽

Yasuaki Sagara ◽

Fumikata Hara ◽

...

Keyword(s):

Invasive Ductal Carcinoma ◽

Ductal Carcinoma In Situ ◽

Tumor Size ◽

Medical Records ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Palpable Mass ◽

Combined Use ◽

A Prospective Study

Abstract Background We conducted a prospective study with the intention to omit surgery for patients with ductal carcinoma in situ (DCIS) of the breast. We aimed to identify clinicopathological predictors of postoperative upstaging to invasive ductal carcinoma (IDC) in patients preoperatively diagnosed with DCIS. Patients and methods We retrospectively analyzed patients with DCIS diagnosed through biopsy between April 1, 2010 and December 31, 2014, from 16 institutions. Clinical, radiological, and histological variables were collected from medical records. Results We identified 2,293 patients diagnosed with DCIS through biopsy, including 1,663 DCIS (72.5%) cases and 630 IDC (27.5%) cases. In multivariate analysis, the presence of a palpable mass (odds ratio [OR] 1.8; 95% confidence interval [CI] 1.2–2.6), mammography findings (≥ category 4; OR 1.8; 95% CI 1.2–2.6), mass formations on ultrasonography (OR 1.8; 95% CI 1.2–2.5), and tumor size on MRI (> 20 mm; OR 1.7; 95% CI 1.2–2.4) were independent predictors of IDC. Among patients with a tumor size on MRI of ≤ 20 mm, the possibility of postoperative upstaging to IDC was 22.1%. Among the 258 patients with non-palpable mass, nuclear grade 1/2, and positive for estrogen receptor, the possibility was 18.1%, even if the upper limit of the tumor size on MRI was raised to ≤ 40 mm. Conclusion We identified four independent predictive factors of upstaging to IDC after surgery among patients with DCIS diagnosed by biopsy. The combined use of various predictors of IDC reduces the possibility of postoperative upstaging to IDC, even if the tumor size on MRI is larger than 20 mm.

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Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast

Yonsei Medical Journal ◽

10.3349/ymj.2006.47.3.333 ◽

2006 ◽

Vol 47 (3) ◽

pp. 333 ◽

Cited By ~ 32

Author(s):

Hee Jung Kim ◽

Chan-il Park ◽

Byeong Woo Park ◽

Hy-de Lee ◽

Woo Hee Jung

Keyword(s):

Invasive Ductal Carcinoma ◽

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Carcinoma Of The Breast

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Ανοστοϊστοχημική εκτίμηση πρωτεϊνών οξείας φάσης σε διηθητικά καρκινώματα μαστού

10.12681/eadd/43283 ◽

2018 ◽

Author(s):

Διονύσιος Δήμας

Keyword(s):

Invasive Ductal Carcinoma ◽

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Matched Pairs

Σκοπός της παρούσας μελέτης είναι η αξιολόγηση της σημασίας της έκφρασης των Hsp70/90 σε ασθενείς με καρκίνο μαστού. Σημαντική προέκταση της εκτίμησης αυτής αποτελεί η αξιολόγηση της σημασίας τους ως δυνητικά μόρια-στόχους στη φαρμακευτική θεραπεία του καρκίνου του μαστού.Μέθοδος: Προκειμένου για την αξιολόγηση της σχέσης αυτής πραγματοποιήθηκε μελέτη σε ιστικά δείγματα από 54 ασθενείς με πορογενή νεοπλάσματα του μαστού. Χρησιμοποιήθηκαν τα κατάλληλα αντιδραστήρια για τη μελέτη της έκφρασης των Hsp70/90 στα δείγματα αυτά, καθώς και της έκφρασης των ER, PR, HER2, Ki67. Παράλληλα εξετάστηκε, η διαφορά έκφρασης μεταξύ καρκινικών και μη ιστών, ο βαθμός ιστολογικής κακοήθειας, το μέγεθος του όγκου, η παρουσία ή μη λεμφαδενικής διήθησης από τον όγκο και η παρουσία απομακρυσμένων μεταστάσεων. Κατόπιν πραγματοποιήθηκε συστηματική ανασκόπηση της βιβλιογραφίας προκειμένου για τον έλεγχο της επίδρασης της έκφρασης των Hsp70/90 στην επιβίωση, το PCNALI, καθώς και στις μεταβλητές που εξετάστηκαν στην πρωτογενή μελέτη της παρούσας διατριβής. Επίσης πραγματοποιήθηκε ποσοτική σύνθεση (μετα-ανάλυση) των σχετικών αποτελεσμάτων των μελετών που περιλήφθηκαν στην ανασκόπηση.Αποτελέσματα: Από τις μεταβλητές που εξετάστηκαν στην πρωτογενή μελέτη δεν προέκυψε κάποια στατιστικά σημαντική συσχέτιση μεταξύ αυτών και της έκφρασης των Hsp70/90. Μόνη εξαίρεση αποτελεί η στατιστικά σημαντική, χαμηλότερη έκφραση της Hsp90 στο IDC (Invasive Ductal Carcinoma) σε σχέση με αυτή στο DCIS (Ductal Carcinoma in Situ) (DCIS (6.54±1.31 vs. 7.16±0.82, αντίστοιχα, p=0.004, Wilcoxon matched-pairs signed-ranks test) και αντίστοιχα, η σημαντικά χαμηλότερη έκφρασή της στο DCIS σε σχέση με αυτήν στο φυσιολογικό παρακείμενο μαστό (p=0.0002, με την ίδια δοκιμασία). Από την συστηματική ανασκόπηση της βιβλιογραφίας, τα μόνα σημεία στα οποία υπήρχε σύμπνοια των αποτελεσμάτων των μελετών, αφορούσαν στην έκφραση της Hsp70 σε σχέση με το PCNALI και στην σημαντικά χειρότερη συνολική επιβίωση των ασθενών με υψηλή έκφραση της Hsp90. Από τη μετα-ανάλυση προέκυψε συσχέτιση της υψηλής έκφρασης της Hsp90 με χειρότερη συνολική επιβίωση και οριακά χειρότερη ελεύθερη-νόσου επιβίωση των ασθενών με καρκίνο μαστού. Η υψηλή έκφραση της Hsp70 συσχετίστηκε επίσης με χειρότερη ελεύθερη-νόσου επιβίωση, καθώς και θετικότητα των οιστρογονικών (ER) και προγεστερονικών (PR) υποδοχέων.Συμπέρασμα: Από τη συστηματική ανασκόπηση και μετα-ανάλυση που πραγματοποιήθηκε στα πλαίσια της παρούσας διατριβής, υπογραμμίζεται η προγνωστική αξία της έκφρασης των Hsp70 και Hsp90 στον καρκίνο του μαστού. Περαιτέρω υψηλής ποιότητας μελέτες, με αναλυτική παρουσίαση των αποτελεσμάτων τους είναι αναγκαίες για την παροχή επιδημιολογικών στοιχείων, που θα συμπληρώσουν τα ευρήματα των εν εξελίξει κλινικών δοκιμών για τους αναστολείς των Hsps.

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