IntroductionMany nanoparticles have pharmacological and biochemical properties, including antioxidant and anti-inflammatory properties, which appear to be involved in anticarcinogenic and antimutagenic activities. In the recent study, nickel nanoparticles were green-synthesized using the Alhagi sparsifolia leaf aqueous extract. Material and methodsThe synthesized Ni nanoparticles were characterized by analytical techniques including SEM, UV-Vis., and FT-IR. The nanoparticles were formed in a spherical shape in the average size of 16.19 nm. ResultsIn the antioxidant test, the IC50 of Ni nanoparticles and BHT against DPPH free radicals were 316 and 231 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with Ni nanoparticles were assessed by MTT assay for 48h about the cytotoxicity and anti-human breast cancer properties on normal (HUVEC) and breast cancer cell lines i.e. lobular carcinoma of breast (UACC-3133), inflammatory carcinoma of the breast (UACC-732), and metastatic carcinoma (MDA-MB-453). The viability of malignant breast cell line reduced dose-dependently in the presence of Ni nanoparticles. The IC50 of Ni nanoparticles were 477, 548, and 605 µg/mL against lobular carcinoma of breast (UACC-3133), inflammatory carcinoma of the breast (UACC-732), and metastatic carcinoma (MDA-MB-453) cell lines, respectively. ConclusionsAfter clinical study, nickel nanoparticles containing Alhagi sparsifolia leaf aqueous extract may be used to formulate a new chemotherapeutic drug or supplement to treat the several types of human breast cancer.
Evolution of an invasive ductal carcinoma to a small cell carcinoma of the breast
