Resting State Functional Magnetic Resonance Study Based on Amplitude of Low-Frequency Fluctuation in Patients with Acute Angle-Closure Glaucoma
Abstract Objective: To investigate the altered brain spontaneous activity in acute angle-closure glaucoma (AACG) using resting-state amplitude of low-frequency fluctuation (ALFF).Methods: Eighteen AACG patients and eighteen age, gender-matched healthy controls (HC) were included in the rs-fMRI scans. Two sample t tests were performed to observe the ALFF changes between AACG and HC. The correlations between ALFF values and the ophthalmologic measurements were analyzed.Results: Compared with HC,AACG patients showed decreased ALFF in the right lingual gyrus, right supra marginal gyrus , left precuneus,left medial superior frontal gyrus, left inferior parietal gyrus , left middle frontal gyrus. Meanwhile AACG patients showed increased ALFF in the right lobule crus2 of cerebellar hemisphere , left V1, right cuneus. In this study, no correlation between brain regions with abnormal ALFF value and intraocular pressure was found.Conclusion: AACG patients have abnormal brain spontaneous activity in the visual, sensual, motional and emotional areas, which provides a new insight into the neuropathological mechanism and treatment of AACG.