Regional Lymph Nodes Distribution Pattern in Central Area of Right-sided Colon Cancer: In-Vivo Detection and the Update on the Clinical Exploration.

2020 ◽  
Author(s):  
Xiaochuang Feng ◽  
Hongming Li ◽  
Xinquan Lu ◽  
Xiaojiang Yi ◽  
Jin Wan ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Distribution Pattern ◽  
Lymphatic Vessels ◽  
Central Area ◽  
Radical Resection ◽  
Pathology Report ◽  
Target Area ◽  
Regional Lymph Nodes

Abstract BackgroundDistribution of regional lymph nodes (LNs) is decisive for the lymphadenectomy boundary in radical resection of a right-sided colon cancer (RCC). Currently, the data of LNs in central area remains ambiguous and scarce. Herein we aim to provide a more detailed anatomical research on LNs surrounding the superior mesenteric vessels for RCC and investigated the metastasis rate.MethodsCarbon Nanoparticles (CNs) or Indocyanine Green (ICG) were used as dye and we laparoscopically observed the stained LNs distribution pattern and analyzed the harvested LNs combined with pathology report. Lastly, 137 RCC patients who received a “superior mesenteric artery (SMA)-oriented” hemicolectomy from September 2016 to September 2020 were included to calculate the probability of LNs metastasis in our target area.Results20 patients diagnosed as RCC (mean age 55.55 years, 13 male) were included. 13 patients underwent CNs injection and 7 patients consented to the ICG, while 4 cases suffered from imaging failure. The unequal number of the regional LNs located between SMV and SMA was detected in 17 cases (85%), posterior to SMV area in 6 cases (30%), and anterior to SMA in 11 cases (55%), respectively. The presence of LNs posterior to SMV was associated with the crossing pattern of ileocolic artery (²= 5.38, p= 0.020). The probability of LNs metastasis in the above areas (target areas) was 2.19% (3/137). No dyed LNs occurred when the SMA sheath was exposed. What’s more, the number of total harvested LNs in patients with dye injection was significant more than dye-free RCC patients (22.44±13.78 vs 43.20±22.70, p<0.01). ConclusionRight-hemi colon-draining lymphatic vessels anteriorly/posteriorly traversed the SMV and arrived at the surface of SMA near the middle colonic artery (MCA) level, which highlights the potential need of CME to place the internal border anterior to SMA and the removal of mesenteric tissue in our target area on lymphatic resection.

Intussusception Due to Vanishing Colon Cancer with Metastasis of the Regional Lymph Nodes: Report of a Case

Surgery Today ◽  
2000 ◽  
Vol 30 (2) ◽  
pp. 188-190 ◽  
Author(s):  
Yasuhiro Fujino ◽  
Yoichi Fujio ◽  
Etsuji Shimada ◽  
Akira Okazaki
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Regional Lymph Nodes

scholarly journals Intracholecystic Papillary-Tubular Neoplasms (ICPNs): A Pathology Report

2021 ◽  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Tumor Marker ◽  
Laboratory Tests ◽  
Hepatic Flexure ◽  
Pathology Report ◽  
Wound Surface ◽  
Polypoid Mass ◽  
High Cholesterol ◽  
Biopsy Report

We presented a 60-year-old man who underwent a colonoscopy examination of a polypoid mass with a wound surface of 1.1 cm in hepatic flexure. An adenocarcinoma of intestinal type was diagnosed based on the biopsy report, and patient was referred to the hospital for colectomy. In colonoscopy and biopsy, the polypoid mass was completely removed, and despite different sections of the whole specimen in the colectomy specimen, any mass was not found, while only one out of three identified lymph nodes were involved. In laboratory tests, CBC had anemia: (Hb: 10.8 mg/ dl), elevated CEA tumor marker (range: 18 ng/ml), and lipid profile disorder together with high cholesterol (300 mg/dl), indicating colon cancer manifestation.

The potential of cytokeratin 20 and mucin 2 mRNA as metastasis markers in regional lymph nodes of colon cancer patients investigated by quantitative RT-PCR

2009 ◽  
Vol 24 (3) ◽  
pp. 261-268 ◽  
Author(s):  
Oddmund Nordgård ◽  
Satu Oltedal ◽  
Hartwig Kørner ◽  
Ole Gunnar Aasprong ◽  
Kjersti Tjensvoll ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Cytokeratin 20 ◽  
Rt Pcr ◽  
Regional Lymph Nodes ◽  
Mucin 2

scholarly journals Whether regional lymph nodes evaluation should be equally required for both right and left colon cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (37) ◽  
pp. 59945-59956 ◽  
Author(s):  
Xu Guan ◽  
Wei Chen ◽  
Zheng Liu ◽  
Zheng Jiang ◽  
Hanqing Hu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Left Colon ◽  
Regional Lymph Nodes ◽  
Left Colon Cancer

In Vivo and Ex Vivo Sentinel Node Mapping Does Not Identify the Same Lymph Nodes in Colon Cancer

2016 ◽  
Vol 223 (4) ◽  
pp. S32-S33
Author(s):  
Helene S. Andersen ◽  
Astrid LB. Bennedsen ◽  
Stefan K. Burgdorf ◽  
Jens R. Eriksen ◽  
Susanne Eiholm ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Sentinel Node ◽  
Ex Vivo ◽  
Sentinel Node Mapping

scholarly journals Essential Role of Platelet-Activating Factor in Control of Leishmania (Leishmania)amazonensis Infection

2000 ◽  
Vol 68 (11) ◽  
pp. 6355-6361 ◽  
Author(s):  
Maria Valdrinez Campana Lonardoni ◽  
Momtchillo Russo ◽  
Sonia Jancar
Keyword(s):  
Lymph Nodes ◽  
Platelet Activating Factor ◽  
Parasite Load ◽  
Peritoneal Macrophages ◽  
Leishmania Infection ◽  
Prostaglandin E ◽  
No Production ◽  
Regional Lymph Nodes

ABSTRACT In the present study we investigated the role of platelet-activating factor (PAF) and prostaglandins in experimental Leishmania (Leishmania)amazonensis infection and the relationship between these mediators and nitric oxide (NO) production. Mouse peritoneal macrophages elicited with thioglicolate were infected with leishmania amastigotes, and the infection index determined 48 h later. The course of infection was monitored for 5 weeks in mice infected in the footpad with promastigotes by measuring the footpad swelling and parasite load in regional lymph nodes and spleen. The addition of PAF to C57BL/6 mouse macrophages significantly inhibited parasite growth and induced NO production. Treatment of macrophages with a selective PAF antagonist, WEB2086, increased the infection, indicating that endogenously produced PAF regulates macrophage ability to control leishmania infection. This effect of PAF was abolished by addition of the inhibitor of NO synthesis, L-NAME, to the cultures. The addition of prostaglandin E2 significantly increased the infection and NO production. Treatment with cyclo-oxygenase inhibitor, indomethacin, reduced the infection and PAF-induced release of NO. Thus, the increased NO production induced by PAF seems to be mediated by prostaglandins. The more-selective inhibitors of cyclo-oxygenase 2, nimesulide and NS-398, had no significant effect. Thus, antileishmanial activity correlates better with the presence of PAF or absence of prostaglandins than with NO production. In vivo treatment with PAF antagonists significantly increased leishmania lesions, as well as the parasite load, in regional lymph nodes and spleens. These findings indicate that PAF is essential for the control of leishmania infection.

Intestinal carcinomas in two tamarins (Saguinus fuscicollis, Saguinus oedipus) of the German Primate Centre

1988 ◽  
Vol 22 (2) ◽  
pp. 144-147 ◽  
Author(s):  
M. Brack
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Lymphatic System ◽  
Saguinus Oedipus ◽  
Regional Lymph Nodes ◽  
Ileocaecal Valve ◽  
Saguinus Fuscicollis ◽  
Well Differentiated

Two colonic mucoid adenocarcinomas in tamarins from the German Primate Centre are reported. A mucinous mucoid adenocarcinoma occurred in the ascending and transversal colon of a Saguinus oedipus male more than 8 years old, with metastases in the regional lymph nodes and the pancreas. The tumour corresponded to colon cancer in cotton-topped tamarins of other colonies. The second tumour, a well differentiated tubular mucoid adenocarcinoma, developed at the ileocaecal valve of a 14&frac12; year old Saguinus fuscicollis male with metastases to the local lymphatic system.

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