Water Powered Bioassay System

2004 ◽  
Author(s):  
Liwei Lin
Keyword(s):  

2013 ◽  
Vol 133 (8) ◽  
pp. 1616-1624
Author(s):  
Zu Soh ◽  
Kentaro Miyamoto ◽  
Akira Hirano ◽  
Toshio Tsuji




1992 ◽  
Vol 64 (2) ◽  
pp. 99-107
Author(s):  
Toshihiro Amanuma ◽  
Hiroshi Maruyama ◽  
Toshifumi Tsujiuchi ◽  
Masahiro Tsutsumi ◽  
Ayumi Denda ◽  
...  


1988 ◽  
Vol 255 (3) ◽  
pp. H446-H451 ◽  
Author(s):  
V. M. Miller ◽  
P. M. Vanhoutte

Chronic increases in blood flow caused by an arteriovenous fistula augment endothelium-dependent relaxations to acetylcholine. To determine whether endothelial muscarinic receptors are altered, concentration-response curves to acetylcholine were obtained in the presence of pirenzepine in fistula- and sham-operated canine femoral arteries. Pirenzepine inhibited the response to acetylcholine in both arteries. The pA2 (log Kb) for the antagonist was the same. A bioassay system was used to assess release of endothelium-derived relaxing factor. Rings of femoral artery (without endothelium) from unoperated dogs relaxed more when superfused with perfusate derived from endothelium of fistula-operated arteries during acetylcholine stimulation. Rings without endothelium of sham- and fistula-operated arteries relaxed to the same extent when superfused with perfusate derived from the endothelium of unoperated femoral arteries. These results suggest that augmented relaxations to acetylcholine in canine arteries where blood flow is chronically elevated do not result from changes in the subtype of endothelial muscarinic receptors or in the sensitivity of the underlying smooth muscle to endothelium-derived relaxing factor(s). They are likely due to increased release of endothelium-derived relaxing factor(s) on muscarinic activation.



1975 ◽  
Author(s):  
T. L. Beitinger ◽  
W. Prepejchal ◽  
J. Haumann ◽  
R. E. Rowland


2012 ◽  
Vol 22 (2) ◽  
pp. 233-241 ◽  
Author(s):  
Xixuan Jin ◽  
Douglas Streett ◽  
Yanbo Huang ◽  
Todd Ugine


Holzforschung ◽  
2004 ◽  
Vol 58 (2) ◽  
pp. 189-192 ◽  
Author(s):  
F. Kawamura ◽  
S. Ohara ◽  
A. Nishida

Abstract Antifungal activity of constituents from the heartwood of the Malaysian Gmelina arborea against Trametes versicolor and Fomitopsis palustris was investigated. A sensitive bioassay system for antifungal activity against basidiomycetes was developed which uses a medium in which homogenized hyphae were dispersed. Ethyl acetate- solubles from the heartwood showed the highest activity against both fungi, although the activity against F. palustris was quite weak. Spots exhibiting antifungal activity against T. versicolor were specified by autobiography of ethyl acetate-solubles, and five constituents were isolated and identified as (+)-7′-O-ethyl arboreol, (+)-paulownin, (+)-gmelinol, (+)-epieudesmin and (−)-β-sitosterol. The four lignans showed antifungal activity, whereas β-sitosterol did not. From the comparison of antifungal activity, it was concluded that the piperonyl nucleus contributed to the activity of lignans. Of the four lignans isolated, gmelinol appeared to be an important antifungal constituent, since it was rich in the heartwood of G. arborea. Furthermore, the synergism by coexistence of these five compounds was confirmed.



1996 ◽  
Vol 79 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Elizabeth W. Davidson ◽  
Rufino B. R. Patron ◽  
Lawrence A. Lacey ◽  
Roger Frutos ◽  
Alain Vey ◽  
...  


Sign in / Sign up

Export Citation Format

Share Document