scholarly journals Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations

2021 ◽  
Vol 46 (8) ◽  
pp. 371-378
Author(s):  
Norie Murayama ◽  
Hiroshi Yamazaki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Metabolic Activation ◽  
Cytochrome P450 Enzymes

Metabolic Activation of Benzo[c]phenanthrene by Cytochrome P450 Enzymes in Human Liver and Lung

2001 ◽  
Vol 14 (6) ◽  
pp. 686-693 ◽  
Author(s):  
Matthias Baum ◽  
Shantu Amin ◽  
F. Peter Guengerich ◽  
Stephen S. Hecht ◽  
Werner Köhl ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Metabolic Activation ◽  
Cytochrome P450 Enzymes

Identification of Human Liver Cytochrome P450 Enzymes Involved in Biotransformation of Vicriviroc, a CCR5 Receptor Antagonist

2007 ◽  
Vol 35 (12) ◽  
pp. 2186-2195 ◽  
Author(s):  
Anima Ghosal ◽  
Ragu Ramanathan ◽  
Yuan Yuan ◽  
Neil Hapangama ◽  
Swapan K. Chowdhury ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Receptor Antagonist ◽  
Human Liver ◽  
Cytochrome P450 Enzymes ◽  
Liver Cytochrome ◽  
Ccr5 Receptor

scholarly journals In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes

2020 ◽  
Vol 58 (1) ◽  
pp. 247-252
Author(s):  
Xunge Zhang ◽  
Ping Feng ◽  
Xinfu Gao ◽  
Bin Wang ◽  
Chunxia Gou ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Cytochrome P450 Enzymes ◽  
Inhibitory Effects ◽  
Liver Cytochrome

Differential selectivity in carbamazepine-induced inactivation of cytochrome P450 enzymes in rat and human liver

2001 ◽  
Vol 75 (9) ◽  
pp. 538-543 ◽  
Author(s):  
Yasuhiro Masubuchi ◽  
Tomohisa Nakano ◽  
Atsushi Ose ◽  
Toshiharu Horie
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Cytochrome P450 Enzymes ◽  
Differential Selectivity

scholarly journals Characterization of O-demethylations and Aromatic Hydroxylations Mediated by Cytochromes P450 in the Metabolism of Flavonoid Aglycons

2019 ◽  
Vol 92 (1) ◽  
pp. 115-123 ◽  
Author(s):  
Goran Benković ◽  
Hrvoje Rimac ◽  
Željan Maleš ◽  
Siniša Tomić ◽  
Zoran Lončar ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Cytochromes P450 ◽  
Liver Microsomes ◽  
Cytochrome P450 Enzymes ◽  
Uv Detector ◽  
Aromatic Hydroxylation ◽  
Metabolism Of Xenobiotics ◽  
Kinetics Of

One of the most important groups of metabolic enzymes is cytochrome P450 superfamily. These enzymes are important in terms of the catalytic diversity and the large number of xenobiotics that are detoxified or activated by converting to reactive metabolites. Flavonoids are xenobiotics to which humans are exposed through diet. Data on their oxidative metabolism mediated by cytochromes P450 are limited. The aim of this study was to determine the enzymatic kinetics of O-demethylation and aromatic hydroxylation of flavonoid aglycons on recombinant cytochrome P450 enzymes and human liver microsomes systems. The study was performed on ten flavonoids, namely 3,7-dihydroxyflavone, 7-hydroxyflavone, acacetin, apigenin, flavone, galangin, kaempferol, naringenin, sakuranetin, and tangeretin using liquid chromatography coupled with mass spectrometry and UV detector. Most relevant enzyme involved in metabolism of flavonoid aglycons is CYP1A2, and its catalytic effectiveness ranges from 0.5 to 2.9 × 106 M–1 min–1. Having in mind high expression and involvement of CYP1A2 in metabolism of xenobiotics including drugs, and its intraindividual differences in expression and activity, potential of drug-flavonoid competitive interactions/inhibitions should be considered when consuming dietary supplement and foods rich in flavonoids.

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