Metabolic Fate of Losartan, a New Angiotensin II Receptor Antagonist. (2). Absorption, Distribution, Metabolism, Excretion and Effects on Drug Metabolizing Enzyme Activities after Repeated Oral Administration in Rats.

Fumio TAKAYAMA; Hiroyuki ISHIZAKI; Tomomi YOSHINAGA; Mitsuko MORITA; Shunsuke HATA; Yoshio ESUMI; Yoshitaka JIN; Yuichi OKAMURA

doi:10.2133/dmpk.10.244

Metabolic Fate of Losartan, a New Angiotensin II Receptor Antagonist. (2). Absorption, Distribution, Metabolism, Excretion and Effects on Drug Metabolizing Enzyme Activities after Repeated Oral Administration in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.244 ◽

1995 ◽

Vol 10 (2) ◽

pp. 244-256 ◽

Cited By ~ 2

Author(s):

Fumio TAKAYAMA ◽

Hiroyuki ISHIZAKI ◽

Tomomi YOSHINAGA ◽

Mitsuko MORITA ◽

Shunsuke HATA ◽

...

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Enzyme Activities ◽

Angiotensin Ii Receptor ◽

Metabolic Fate ◽

Angiotensin Ii Receptor Antagonist ◽

Drug Metabolizing Enzyme ◽

Metabolizing Enzyme

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Phase I Study of MK-954, a New Angiotensin II Receptor Antagonist. Results of Single Oral Administration.

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics ◽

10.3999/jscpt.26.671 ◽

1995 ◽

Vol 26 (3) ◽

pp. 671-684 ◽

Cited By ~ 3

Author(s):

Mitsuyoshi NAKASHIMA ◽

Mitsutaka KANAMARU ◽

Toshihiko UEMATSU ◽

Fumio TAKAYAMA ◽

Kazuo KAMEI

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Phase I ◽

Receptor Antagonist ◽

Phase I Study ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist ◽

Single Oral Administration

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Pharmacological Profiles of a Highly Potent and Long-Acting Angiotensin II Receptor Antagonist, Fimasartan, in Rats and Dogs after Oral Administration

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.b16-00987 ◽

2017 ◽

Vol 40 (7) ◽

pp. 992-1001 ◽

Cited By ~ 3

Author(s):

Soo Heui Paik ◽

Yong Ha Chi ◽

Joo Han Lee ◽

Hee-Soo Han ◽

Kyung-Tae Lee

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist ◽

Long Acting ◽

Pharmacological Profiles

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Antihypertensive effects of acute and chronic oral administration of KT3-671, a novel angiotensin II receptor antagonist, in renal hypertensive dogs.

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)37529-8 ◽

1996 ◽

Vol 71 ◽

pp. 322

Author(s):

Shingo Tajima ◽

Yoshinobu Takata ◽

Hitoshi Kato

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist

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Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.1992.56 ◽

1992 ◽

Vol 51 (5) ◽

pp. 513-521 ◽

Cited By ~ 133

Author(s):

Alain Munafo ◽

Yves Christen ◽

Jürg Nussberger ◽

Linyee Y Shum ◽

R Michael Borland ◽

...

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Drug Concentration ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist ◽

Normal Volunteers

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Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers. Inhibition of pressor response to exogenous angiotensin I and II.

Circulation ◽

10.1161/01.cir.83.4.1333 ◽

1991 ◽

Vol 83 (4) ◽

pp. 1333-1342 ◽

Cited By ~ 163

Author(s):

Y Christen ◽

B Waeber ◽

J Nussberger ◽

M Porchet ◽

R M Borland ◽

...

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Pressor Response ◽

Normal Male ◽

Angiotensin Ii Receptor ◽

Angiotensin I ◽

Angiotensin Ii Receptor Antagonist ◽

Male Volunteers

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Metabolic Fate of Losartan, a New Angiotensin II Receptor Antagonist. (3). Transfer into Fetus and Milk in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.257 ◽

1995 ◽

Vol 10 (2) ◽

pp. 257-268

Author(s):

Fumio TAKAYAMA ◽

Shunsuke HATA ◽

Yoshio ESUMI ◽

Yoshitaka JIN ◽

Yuichi OKAMURA

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Metabolic Fate ◽

Angiotensin Ii Receptor Antagonist

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Studies on the metabolic fate of (.+-.)-1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-isopropylamino-2-propanol hydrochloride (betaxolol hydrochloride). (2): Blood level profiles, distribution, metabolism, excretion, aecumulation and effects on the hepatic drug-metabolizing enzyme activities of betaxolol after repeated oral administration to rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.5.699 ◽

1990 ◽

Vol 5 (5) ◽

pp. 699-710

Author(s):

Seiu IIDA ◽

Tomio INOKUCHI ◽

Masato IWAMOTO ◽

Yukimi YONEYAMA ◽

Jun TATSUNO ◽

...

Keyword(s):

Oral Administration ◽

Blood Level ◽

Enzyme Activities ◽

Metabolic Fate ◽

Hepatic Drug ◽

Drug Metabolizing Enzyme ◽

Metabolizing Enzyme

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Phase I Study of MK-954, a New Angiotensin II Receptor Antagonist. Results of Multiple Oral Administration.

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics ◽

10.3999/jscpt.26.685 ◽

1995 ◽

Vol 26 (3) ◽

pp. 685-696

Author(s):

Mitsuyoshi NAKASHIMA ◽

Mitsutaka KANAMARU ◽

Toshihiko UEMATSU ◽

Fumio TAKAYAMA ◽

Kazuo KAMEI

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Phase I ◽

Receptor Antagonist ◽

Phase I Study ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist

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Studies on the Metabolic Fate of Leukotriene Antagonist ONO-1078. (2). Absorption, Distribution, Excretion and Effects on Drug Metabolizing Enzyme Activities after Repeated Oral Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.8.27 ◽

1993 ◽

Vol 8 (1) ◽

pp. 27-38

Author(s):

Masatsune ISHIDO ◽

Kimio SHIBAKAWA ◽

Masafumi SAWADA ◽

Hideki AISHITA

Keyword(s):

Oral Administration ◽

Enzyme Activities ◽

Metabolic Fate ◽

Drug Metabolizing Enzyme ◽

Leukotriene Antagonist ◽

Metabolizing Enzyme

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Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, an orally active nonpeptide angiotensin II receptor antagonist, in humans.

British Journal of Clinical Pharmacology ◽

10.1111/j.1365-2125.1993.tb05696.x ◽

1993 ◽

Vol 35 (3) ◽

pp. 290-297 ◽

Cited By ~ 106

Author(s):

M. Ohtawa ◽

F. Takayama ◽

K. Saitoh ◽

T. Yoshinaga ◽

M. Nakashima

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist ◽

Orally Active

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