Metabolic Fate of Losartan, a New Angiotensin II Receptor Antagonist. (3). Transfer into Fetus and Milk in Rats.

Fumio TAKAYAMA; Shunsuke HATA; Yoshio ESUMI; Yoshitaka JIN; Yuichi OKAMURA

doi:10.2133/dmpk.10.257

Metabolic Fate of Losartan, a New Angiotensin II Receptor Antagonist. (3). Transfer into Fetus and Milk in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.257 ◽

1995 ◽

Vol 10 (2) ◽

pp. 257-268

Author(s):

Fumio TAKAYAMA ◽

Shunsuke HATA ◽

Yoshio ESUMI ◽

Yoshitaka JIN ◽

Yuichi OKAMURA

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Metabolic Fate ◽

Angiotensin Ii Receptor Antagonist

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Metabolic Fate of Losartan, a New Angiotensin II Receptor Antagonist. (1). Absorption, Distribution, Metabolism and Excretion after Single Administration in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.223 ◽

1995 ◽

Vol 10 (2) ◽

pp. 223-243 ◽

Cited By ~ 3

Author(s):

Fumio TAKAYAMA ◽

Kaoru SAITO ◽

Tomomi YOSHINAGA ◽

Mitsuko MORITA ◽

Shunsuke HATA ◽

...

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Single Administration ◽

Angiotensin Ii Receptor ◽

Metabolic Fate ◽

Angiotensin Ii Receptor Antagonist

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Metabolic Fate of Losartan, a New Angiotensin II Receptor Antagonist. (2). Absorption, Distribution, Metabolism, Excretion and Effects on Drug Metabolizing Enzyme Activities after Repeated Oral Administration in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.244 ◽

1995 ◽

Vol 10 (2) ◽

pp. 244-256 ◽

Cited By ~ 2

Author(s):

Fumio TAKAYAMA ◽

Hiroyuki ISHIZAKI ◽

Tomomi YOSHINAGA ◽

Mitsuko MORITA ◽

Shunsuke HATA ◽

...

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Enzyme Activities ◽

Angiotensin Ii Receptor ◽

Metabolic Fate ◽

Angiotensin Ii Receptor Antagonist ◽

Drug Metabolizing Enzyme ◽

Metabolizing Enzyme

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Chronic hemodynamic and antifibrotic effects of a specific angiotensin II receptor antagonist (losartan) in bile duct ligated (BDL) rats and in portal vein ligated (PVL) rats

Journal of Hepatology ◽

10.1016/s0168-8278(01)80311-1 ◽

2001 ◽

Vol 34 (0) ◽

pp. 88

Author(s):

V Croquet

Keyword(s):

Angiotensin Ii ◽

Bile Duct ◽

Portal Vein ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist

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Angiotensin II Receptor Antagonist Improves the Immune Activations of Patients With Chronic Heart Failure

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)83860-0 ◽

1998 ◽

Vol 31 (2) ◽

pp. 33A

Author(s):

T Tsutamoto

Keyword(s):

Heart Failure ◽

Angiotensin Ii ◽

Chronic Heart Failure ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist

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Systemic and splanchnic effects of acute administration of losartan — a specific angiotensin II receptor antagonist — in normal and portal hypertensive rats

Journal of Hepatology ◽

10.1016/s0168-8278(01)81092-8 ◽

2001 ◽

Vol 34 ◽

pp. 64

Author(s):

V. Croquet ◽

F. Oberti ◽

F. Moal ◽

J. Wang ◽

J. Roux ◽

...

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Acute Administration ◽

Angiotensin Ii Receptor ◽

Hypertensive Rats ◽

Angiotensin Ii Receptor Antagonist

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An efficient synthesis of a rationally designed 1,5 disubstituted imidazole AT1 Angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies

Journal of Computer-Aided Molecular Design ◽

10.1007/s10822-010-9371-3 ◽

2010 ◽

Vol 24 (9) ◽

pp. 749-758 ◽

Cited By ~ 14

Author(s):

George Agelis ◽

Panagiota Roumelioti ◽

Amalia Resvani ◽

Serdar Durdagi ◽

Maria-Eleni Androutsou ◽

...

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Docking Studies ◽

Efficient Synthesis ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist ◽

Receptor Affinity

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Effects of combined administration of ACE inhibitor and angiotensin II receptor antagonist are prevented by a high NaCl intake

Journal of Hypertension ◽

10.1097/00004872-200111000-00021 ◽

2001 ◽

Vol 19 (11) ◽

pp. 2087-2095 ◽

Cited By ~ 38

Author(s):

Cory D. Griffiths ◽

Trefor O. Morgan ◽

Leanne M. D. Delbridge

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Ace Inhibitor ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist ◽

Combined Administration

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Angiotensin II receptor antagonist (Olmesartan) associated gastro-entero-colopathy. The multiform expressions of damage due to this class of drugs

Digestive and Liver Disease ◽

10.1016/j.dld.2021.07.035 ◽

2021 ◽

Author(s):

V. Villanacci ◽

R. Del Sordo

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist

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Prevention of intimal thickening after endothelial removal by a nonpeptide angiotensin II receptor antagonist, losartan

British Journal of Pharmacology ◽

10.1111/j.1476-5381.1992.tb14392.x ◽

1992 ◽

Vol 106 (3) ◽

pp. 665-671 ◽

Cited By ~ 57

Author(s):

Hiroshi Azuma ◽

Yasunari Niimi ◽

Hidehisa Hamasaki

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Intimal Thickening ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist

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Angiotensin II Receptor Antagonist Attenuates Expression of Aging Markers in Diabetic Mouse Heart

Circulation Journal ◽

10.1253/circj.70.482 ◽

2006 ◽

Vol 70 (4) ◽

pp. 482-488 ◽

Cited By ~ 21

Author(s):

Rie Kosugi ◽

Tetsuo Shioi ◽

Kayo Watanabe-Maeda ◽

Yuki Yoshida ◽

Keiko Takahashi ◽

...

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Diabetic Mouse ◽

Mouse Heart ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist

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