This paper discusses about unprecedented challenges in consequence of globalization and competitive market conditions which manufacturing industries have to face with. Besides changing environmental regulation and social and regional demand, these challenges, will introduce e-manufacturing concept to deal with the recent needs. Manufacturers become more agile and nimble by development of internet. On one hand, it affects differently on the sections of process industries. On the other hand, it makes more demand for products and more opportunities to sell and market the products. To support this new concept, E-Manufacturing enablers will be introduced and finally, developments for next generation are discussed.