scholarly journals A Polymorphic Residue That Attenuates Interferon Lambda 4 Activity in Hominid Lineages

2018 ◽  
Author(s):  
Connor G. G. Bamford ◽  
Elihu Aranday-Cortes ◽  
Inns Cordeiro Filipe ◽  
Swathi Sukumar ◽  
Daniel Mair ◽  
...  
Keyword(s):  
Interferon Lambda ◽  
Polymorphic Residue

scholarly journals A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages

2018 ◽  
Vol 14 (10) ◽  
pp. e1007307 ◽  
Author(s):  
Connor G. G. Bamford ◽  
Elihu Aranday-Cortes ◽  
Ines Cordeiro Filipe ◽  
Swathi Sukumar ◽  
Daniel Mair ◽  
...  
Keyword(s):  
Interferon Lambda ◽  
Polymorphic Residue

Antiviral Effect of Interferon Lambda Against Lymphocytic Choriomeningitis Virus

2015 ◽  
Vol 35 (7) ◽  
pp. 540-553 ◽  
Author(s):  
Lubomira Lukacikova ◽  
Ingrid Oveckova ◽  
Tatiana Betakova ◽  
Katarina Laposova ◽  
Katarina Polcicova ◽  
...  
Keyword(s):  
Antiviral Effect ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus ◽  
Interferon Lambda

145 Interferon Lambda (IL-29) Downregulates the Human Th2 Response

Cytokine ◽  
2007 ◽  
Vol 39 (1) ◽  
pp. 40
Author(s):  
Shekar Srinivas ◽  
Jeff Babad ◽  
Joyce Eskdale ◽  
Shih-hsin Kan ◽  
Grant Gallagher
Keyword(s):  
Th2 Response ◽  
Interferon Lambda

scholarly journals Enhanced serum interferon-lambda 1 interleukin-29 levels in patients with psoriasis vulgaris

2021 ◽  
Author(s):  
Li-xin Fu ◽  
Tao Chen ◽  
Zai-Pei Guo ◽  
Na Cao ◽  
Li-Wen Zhang ◽  
...  
Keyword(s):  
Psoriasis Vulgaris ◽  
Interferon Lambda

A polymorphic residue in the amino terminal α 1 hemi-domain of the mouse Ld class I molecule affects its assembly and surface expression

1994 ◽  
Vol 31 (15) ◽  
pp. 1169-1180 ◽  
Author(s):  
Beth L. Talken ◽  
Karin Peterson ◽  
Lisa G. Harrison ◽  
David R. Lee
Keyword(s):  
Surface Expression ◽  
Class I ◽  
Amino Terminal ◽  
Polymorphic Residue

scholarly journals Human but Not Mouse Hepatocytes Respond to Interferon-Lambda In Vivo

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e87906 ◽  
Author(s):  
Pascale Hermant ◽  
Céline Demarez ◽  
Tanel Mahlakõiv ◽  
Peter Staeheli ◽  
Philip Meuleman ◽  
...  
Keyword(s):  
Interferon Lambda ◽  
Mouse Hepatocytes

Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A

2015 ◽  
Vol 63 (3) ◽  
pp. 554-563 ◽  
Author(s):  
Sakura Akamatsu ◽  
C. Nelson Hayes ◽  
Hidenori Ochi ◽  
Takuro Uchida ◽  
Hiromi Kan ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structural Protein ◽  
Interferon Lambda

scholarly journals The Most Polymorphic Residue on Plasmodium falciparum Apical Membrane Antigen 1 Determines Binding of an Invasion-Inhibitory Antibody

2006 ◽  
Vol 74 (5) ◽  
pp. 2628-2636 ◽  
Author(s):  
A. M. Coley ◽  
K. Parisi ◽  
R. Masciantonio ◽  
J. Hoeck ◽  
J. L. Casey ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Apical Membrane ◽  
Site Directed Mutagenesis ◽  
Supporting Evidence ◽  
Inhibitory Antibody ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen ◽  
Immune Pressure ◽  
Polymorphic Residue

ABSTRACT Apical membrane antigen 1 (AMA1) is currently one of the leading malarial vaccine candidates. Anti-AMA1 antibodies can inhibit the invasion of erythrocytes by Plasmodium merozoites and prevent the multiplication of blood-stage parasites. Here we describe an anti-AMA1 monoclonal antibody (MAb 1F9) that inhibits the invasion of Plasmodium falciparum parasites in vitro. We show that both reactivity of MAb 1F9 with AMA1 and MAb 1F9-mediated invasion inhibition were strain specific. Site-directed mutagenesis of a fragment of AMA1 displayed on M13 bacteriophage identified a single polymorphic residue in domain I of AMA1 that is critical for MAb 1F9 binding. The identities of all other polymorphic residues investigated in this domain had little effect on the binding of the antibody. Examination of the P. falciparum AMA1 crystal structure localized this residue to a surface-exposed α-helix at the apex of the polypeptide. This description of a polymorphic inhibitory epitope on AMA1 adds supporting evidence to the hypothesis that immune pressure is responsible for the polymorphisms seen in this molecule.

Interferon Lambda: Toward a Dual Role in Cancer

2019 ◽  
Vol 39 (1) ◽  
pp. 22-29 ◽  
Author(s):  
Ahmed Lasfar ◽  
Andrew Zloza ◽  
Ann W. Silk ◽  
Leonard Y. Lee ◽  
Karine A. Cohen-Solal
Keyword(s):  
Dual Role ◽  
Interferon Lambda
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