scholarly journals Gper in the Rostral Ventromedial Medulla is Essential for Mobilizing Descending Inhibition of Itch

2020 ◽  
Author(s):  
Ting Gao ◽  
Li Dong ◽  
Jiahong Qian ◽  
Xiaowei Ding ◽  
Yi Zheng ◽  
...  
2021 ◽  
Author(s):  
Taylor Follansbee ◽  
Dan Domocos ◽  
Eileen Nguyen ◽  
Amanda Nguyen ◽  
Aristea Bountouvas ◽  
...  

The rostral ventromedial medulla (RVM) is important in descending modulation of spinal nociceptive transmission, but it is unclear if these descending pathways also modulate spinal pruriceptive transmission. RVM ON cells are activated by noxious algesic and pruritic stimuli and are pronociceptive. Many RVM-spinal projection neurons express the neurokinin-1 receptor (Tacr1), and ON-cells are excited by local administration of substance P (SP). We hypothesized that Tacr1-expressing RVM ON cells exert an inhibitory effect on itch opposite to their pronociceptive action. Intramedullary microinjection of SP significantly potentiated RVM ON cells and reduced pruritogen-evoked scratching while facilitating mechanical nociception. Chemogenetic activation of RVM Tacr1-expressing RVM neurons also reduced acute pruritogen-evoked scratching behavior while enhancing mechanonociception. Optotagging experiments confirmed RVM Tacr1-expressing neurons to be ON cells. We conclude that Tacr1-expressing ON cells in RVM play a significant role in the descending inhibition of spinal pruriceptive transmission.


Pain ◽  
2011 ◽  
Vol 152 (12) ◽  
pp. 2701-2709 ◽  
Author(s):  
Milena De Felice ◽  
Raul Sanoja ◽  
Ruizhong Wang ◽  
Louis Vera-Portocarrero ◽  
Janice Oyarzo ◽  
...  

2021 ◽  
pp. 147539
Author(s):  
Jing-Shi Tang ◽  
Chen Yu Chiang ◽  
Jonathan O. Dostrovsky ◽  
Dongyuan Yao ◽  
Barry J. Sessle

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