Inhibition, but Not Excitation, Recovers From Partial Cone Loss With Greater Spatiotemporal Integration, Synapse Density and Frequency

2021 ◽  
Author(s):  
Joo Yeun Lee ◽  
Rachel A. Care ◽  
David B. Kastner ◽  
Luca Della Santina ◽  
Felice Dunn
Keyword(s):  
Partial Cone ◽  
Synapse Density ◽  
Spatiotemporal Integration

Automated Cardiac Output Measurement by Spatiotemporal Integration of Color Doppler Data

Circulation ◽  
1997 ◽  
Vol 95 (4) ◽  
pp. 932-939 ◽  
Author(s):  
Jing Ping Sun ◽  
Min Pu ◽  
Fetnat M. Fouad ◽  
Raymond Christian ◽  
William J. Stewart ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Color Doppler ◽  
Cardiac Output Measurement ◽  
Output Measurement ◽  
Doppler Data ◽  
Spatiotemporal Integration

scholarly journals The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum

2021 ◽  
Author(s):  
Fei Wang ◽  
Qianqian Wang ◽  
Baowei Liu ◽  
Lisheng Mei ◽  
Sisi Ma ◽  
...  
Keyword(s):  
Noncoding Rna ◽  
Cerebellar Atrophy ◽  
Synaptic Activity ◽  
Motor Dysfunction ◽  
Cerebellar Development ◽  
Full Spectrum ◽  
Density Reduction ◽  
Adult Mice ◽  
Synapse Density ◽  
And Function

AbstractThe brain is known to express many long noncoding RNAs (lncRNAs); however, whether and how these lncRNAs function in modulating synaptic stability remains unclear. Here, we report a cerebellum highly expressed lncRNA, Synage, regulating synaptic stability via at least two mechanisms. One is through the function of Synage as a sponge for the microRNA miR-325-3p, to regulate expression of the known cerebellar synapse organizer Cbln1. The other function is to serve as a scaffold for organizing the assembly of the LRP1-HSP90AA1-PSD-95 complex in PF-PC synapses. Although somewhat divergent in its mature mRNA sequence, the locus encoding Synage is positioned adjacent to the Cbln1 loci in mouse, rhesus macaque, and human, and Synage is highly expressed in the cerebella of all three species. Synage deletion causes a full-spectrum cerebellar ablation phenotype that proceeds from cerebellar atrophy, through neuron loss, on to synapse density reduction, synaptic vesicle loss, and finally to a reduction in synaptic activity during cerebellar development; these deficits are accompanied by motor dysfunction in adult mice, which can be rescued by AAV-mediated Synage overexpression from birth. Thus, our study demonstrates roles for the lncRNA Synage in regulating synaptic stability and function during cerebellar development.

scholarly journals Dynamic Causal Modeling of Spatiotemporal Integration of Phonological and Semantic Processes: An Electroencephalographic Study

2012 ◽  
Vol 32 (12) ◽  
pp. 4297-4306 ◽  
Author(s):  
G. Yvert ◽  
M. Perrone-Bertolotti ◽  
M. Baciu ◽  
O. David
Keyword(s):  
Causal Modeling ◽  
Dynamic Causal Modeling ◽  
Electroencephalographic Study ◽  
Spatiotemporal Integration ◽  
Semantic Processes

scholarly journals BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin–β-catenin interactions

2006 ◽  
Vol 174 (2) ◽  
pp. 289-299 ◽  
Author(s):  
Shernaz X. Bamji ◽  
Beatriz Rico ◽  
Nikole Kimes ◽  
Louis F. Reichardt
Keyword(s):  
Synaptic Vesicle ◽  
Synaptic Vesicles ◽  
Hippocampal Neurons ◽  
Molecular Mechanisms ◽  
Synapse Formation ◽  
Time Lapse ◽  
Synapse Density ◽  
Vesicle Mobility ◽  
Small Clusters ◽  
Vertebrate Central Nervous System

Neurons of the vertebrate central nervous system have the capacity to modify synapse number, morphology, and efficacy in response to activity. Some of these functions can be attributed to activity-induced synthesis and secretion of the neurotrophin brain-derived neurotrophic factor (BDNF); however, the molecular mechanisms by which BDNF mediates these events are still not well understood. Using time-lapse confocal analysis, we show that BDNF mobilizes synaptic vesicles at existing synapses, resulting in small clusters of synaptic vesicles “splitting” away from synaptic sites. We demonstrate that BDNF's ability to mobilize synaptic vesicle clusters depends on the dissociation of cadherin–β-catenin adhesion complexes that occurs after tyrosine phosphorylation of β-catenin. Artificially maintaining cadherin–β-catenin complexes in the presence of BDNF abolishes the BDNF-mediated enhancement of synaptic vesicle mobility, as well as the longer-term BDNF-mediated increase in synapse number. Together, this data demonstrates that the disruption of cadherin–β-catenin complexes is an important molecular event through which BDNF increases synapse density in cultured hippocampal neurons.

Structure of the partial cone conformer of 25,26,27,28-tetrakis[(2-pyridylmethyl)oxy]calix[4]arene

1993 ◽  
Vol 49 (8) ◽  
pp. 1537-1540 ◽  
Author(s):  
G. Ferguson ◽  
J. F. Gallagher ◽  
S. Pappalardo
Keyword(s):  
Partial Cone

scholarly journals Infant use of relative motion as information for form: Evidence for spatiotemporal integration of complex motion displays

1993 ◽  
Vol 53 (2) ◽  
pp. 190-199 ◽  
Author(s):  
Romy V. Spitz ◽  
Joan Stiles ◽  
Ralph M. Siegel
Keyword(s):  
Relative Motion ◽  
Complex Motion ◽  
Spatiotemporal Integration

scholarly journals An investigation of partial cone cracks in silicon nitride balls

2008 ◽  
Vol 45 (25-26) ◽  
pp. 6301-6315 ◽  
Author(s):  
George Levesque ◽  
Nagaraj K. Arakere
Keyword(s):  
Silicon Nitride ◽  
Partial Cone

Synthesis of Cone, Partial-Cone, and 1,3-Alternate 25,27-Bis[1-(2-ethyl)hexyl]- and 25,27-Bis[1-(2-tert-butoxy)ethyl]calix[4]arene-crown-6 Conformers as Potential Selective Cesium Extractants

2000 ◽  
Vol 65 (24) ◽  
pp. 8283-8289 ◽  
Author(s):  
Jean Guillon ◽  
Jean-Michel Léger ◽  
Pascal Sonnet ◽  
Christian Jarry ◽  
Max Robba
Keyword(s):  
Partial Cone ◽  
Ethyl Hexyl
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