Improved Model for Vocal Folds with a Polyp with Potential Application

Purpose: Voluntary cough dysfunction is highly prevalent across multiple patient populations. Voluntary cough has been utilized as a screening tool for swallowing safety deficits and as a target for compensatory and exercise-based dysphagia management. However, it remains unclear whether voluntary cough dysfunction is associated with the ability to effectively clear the airway. Method: Individuals with neurodegenerative disorders performed same-day voluntary cough testing and flexible endoscopic evaluations of swallowing (FEES). Participants who were cued to cough after exhibiting penetration to the vocal folds and/or aspiration with thin liquids during FEES met inclusion criteria. One-hundred and twenty-three trials were blinded, and the amount of residue before and after a cued cough on FEES was measured with a visual analog scale. Linear and binomial mixed-effects models examined the relationship between cough airflow during voluntary cough testing and the proportion of residue expelled. Results: Peak expiratory flow rate ( p = .004) and cough expired volume from the entire epoch ( p = .029) were significantly associated with the proportion of aspiration expelled from the subglottis. Peak expiratory flow rate values of 3.00 L/s, 3.50 L/s, and 5.30 L/s provided high predicted probabilities that ≥ 25%, ≥ 50%, and ≥ 80% aspirate was expelled. Accounting for depth of aspiration significantly improved model fit ( p < .001). Conclusions: These findings suggest that voluntary cough airflow is associated with cough effectiveness to clear aspiration from the subglottis, although aspiration amount and depth may play an important role in this relationship. These findings provide further support for the clinical utility of voluntary cough in the management of dysphagia.

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Post-mortem Peyer’s patches: Their potential application in forensic medicine

Immunopharmacology and Immunotoxicology ◽

10.1080/08923970902902437 ◽

2009 ◽

Vol 00 (00) ◽

pp. 090513010017019-7

Author(s):

Biagio Solarino ◽

Giancarlo Di Vella ◽

Thea Magrone ◽

Felicita Jirillo ◽

Angela Tafaro ◽

...

Keyword(s):

Forensic Medicine ◽

Potential Application ◽

Peyer's Patches ◽

Peyer’S Patches ◽

Post Mortem

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Immunomodulation using genetically engineered bacteria for type III-mediated delivery of heterologous antigens and cytokines: Potential application in vaccine and therapeutical developments

Immunopharmacology and Immunotoxicology ◽

10.1080/08923970902817890 ◽

2009 ◽

Vol 00 (00) ◽

pp. 090924084723050-4

Author(s):

Mustapha Chamekh

Keyword(s):

Potential Application ◽

Genetically Engineered ◽

Type Iii ◽

Genetically Engineered Bacteria ◽

Heterologous Antigens ◽

Engineered Bacteria

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Comparison of Caseinolytic and Fibrinolytic Assays for Plasmin (Fibrinolysin) in “Fibrinolytic Agents”

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649426 ◽

1966 ◽

Vol 15 (01/02) ◽

pp. 252-272

Author(s):

K. M Moser ◽

Mary Belle Frey

Keyword(s):

Linear Relationship ◽

Potential Application ◽

Fibrinolytic Agents ◽

Linear Portion

Summary1. Caseinolytic and fibrinolytic systems for assay of plasmin in fibrinolytic agents are described which are based upon the determinations of AE/min during the linear portion of the casein-plasmin and fibrin-plasmin reaction curves respectively. A " caseinolytic-rate " unit and “fibrinolytic-rate " unit of ÄE/min × 103 during the linear portion of the respective curves are proposed.2. Data are presented indicating that a reliably linear relationship exists between plasmin concentration and these caseinolytic - and fibrinolytic-rate units.3. Data comparing results obtained with the proposed assay techniques and previously-used casein and fibrinolytic techniques are presented.4. Formulae by which caseinolytic-rate and fibrinolytic-rate units can be roughly converted into Remmert-Cohen type plasmin units are offered.5. The theoretical and practical problems which have influenced development of assays for fibrinolytic components are discussed.6. The advantages of the plasmin “rate unit” techniques vis a vis existing assays are delineated.7. The potential application of the techniques to measurements other than the plasmin content of fibrinolytic agents is discussed.

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