scholarly journals The relationship between the PD-1/PD-L1 pathway and DNA mismatch repair in cervical cancer and its clinical significance

2018 ◽  
Vol Volume 10 ◽  
pp. 105-113 ◽  
Author(s):  
Yang-chun Feng ◽  
Wen-li Ji ◽  
Na Yue ◽  
Yan-chun Huang ◽  
Xiu-min Ma
Keyword(s):  
Cervical Cancer ◽  
Mismatch Repair ◽  
Clinical Significance ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
The Relationship

scholarly journals Modern Aspects of the Structural and Functional Organization of the DNA Mismatch Repair System

Acta Naturae ◽  
2013 ◽  
Vol 5 (3) ◽  
pp. 17-34 ◽  
Author(s):  
S. A. Perevoztchikova ◽  
E. A. Romanova ◽  
T. S. Oretskaya ◽  
P. Friedhoff ◽  
E. A. Kubareva
Keyword(s):  
Mismatch Repair ◽  
Functional Organization ◽  
Dna Mismatch Repair ◽  
Repair Process ◽  
Repair System ◽  
Dna Mismatch ◽  
Dna Mismatch Repair System ◽  
Mismatch Repair System ◽  
General Aspects ◽  
The Relationship

This review is focused on the general aspects of the DNA mismatch repair (MMR) process. The key proteins of the DNA mismatch repair system are MutS and MutL. To date, their main structural and functional characteristics have been thoroughly studied. However, different opinions exist about the initial stages of the mismatch repair process with the participation of these proteins. This review aims to summarize the data on the relationship between the two MutS functions, ATPase and DNA-binding, and to systematize various models of coordination between the mismatch site and the strand discrimination site in DNA. To test these models, novel techniques for the trapping of short-living complexes that appear at different MMR stages are to be developed.

A DNA mismatch repair gene links to the Ph2 locus in wheat

Genome ◽  
2002 ◽  
Vol 45 (1) ◽  
pp. 116-124 ◽  
Author(s):  
Chongmei Dong ◽  
Ryan Whitford ◽  
Peter Langridge
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Reproductive Organs ◽  
Mismatch Repair Gene ◽  
Repair Gene ◽  
Dna Mismatch ◽  
High Level ◽  
The Relationship ◽  
Maximum Expression ◽  
Dna Mismatch Repair Gene

DNA mismatch repair is an essential system for maintaining genetic stability in bacteria and higher eukaryotes. Based on the conserved regions of the bacterial MutS gene and its homologues in yeast and human, a wheat cDNA homologue of MSH6, designated TaMSH7, was isolated by RT–PCR. The deduced amino acid sequence of TaMSH7 shows conserved domains characteristic of other MSH6 genes, with highest similarity to maize MSH7 and Arabidopsis MSH7. TaMSH7 is expressed in meristem tissue associated with a high level of mitotic and meiotic activity, with maximum expression in the reproductive organs of young flower spikes. TaMSH7 is located on the short arms of chromosomes 3A, 3B, and 3D and has been mapped within barley chromosome 3HS. The copy on 3DS is located within the region deleted in the wheat mutant ph2a, which shows altered recombination frequency in the interspecific hybrids. The relationship between the ph2a mutant and TaMSH7 gene function is discussed.Key words: wheat, DNA mismatch repair gene, expression, chromosomal location, Ph2.

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