scholarly journals Impact of combination of local carbonic anhydrase inhibitors and beta-blockers on intraocular pressure, visual functions and eye hemodynamics in primary open-angle glaucoma

2021 ◽  
Vol 14 (2) ◽  
pp. 96-102
Author(s):  
T. N. Malishevskaya ◽  
T. N. Kiseleva ◽  
A. S. Vlasova ◽  
E. K. Eliseeva
Keyword(s):  
Blood Flow ◽  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Beta Blockers ◽  
Visual Fields ◽  
Significant Risk ◽  
Open Angle ◽  
Treatment Optimization ◽  
Visual Functions

Drug treatment optimization in primary open-angle glaucoma (POAG) is a topical issue of ophthalmology in recent decades. The review focuses on the choice of local hypotensive therapy and the effectiveness of a fixed combination (FC) of dorzolamide / timolol in glaucoma treatment. Since decreased perfusion eye pressure and disturbed regulation of local hemodynamics affect the development and progression of glaucomatous optical neuropathy, the use of anti-glaucomatous drugs or other hypotensive agents requires taking account of their effect on intraocular pressure (IOP), visual functions, and ocular blood flow. Most studies show that the hypotensive and hemodynamic effects of dorzolamide/timolol FC contribute to the preservation of visual fields in POAG patients by reducing significant risk factors for POAG progression, such as increased IOP and blood flow deficiency in the retinal and choroidal vessels. Improved hemodynamic parametersdue to local hypotensive treatment can be considered as basis for visual function stabilization, especially in long-term chronic courses of the disease.

Effects of Betaxolol and Latanoprost on Ocular Blood flow and Visual Fields in Patients with Primary Open-Angle Glaucoma

2004 ◽  
Vol 14 (3) ◽  
pp. 211-219 ◽  
Author(s):  
E.F. Erkin ◽  
S. Tarhan ◽  
Ö.R. Kayikçioğlu ◽  
H. Devecı ◽  
C. Güler ◽  
...  
Keyword(s):  
Blood Flow ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Visual Fields ◽  
Ocular Blood Flow ◽  
Open Angle

scholarly journals Complex use of energetic surgery in treatment of patients with primary open-angle glaucoma and cataract on the background of pseudoexfoliative syndrome

2021 ◽  
Vol 14 (3) ◽  
pp. 25-34
Author(s):  
Benta G. Dzhashi ◽  
Sergei V. Balalin
Keyword(s):  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Hypotensive Effect ◽  
Open Angle ◽  
Selective Laser Trabeculoplasty ◽  
Visual Functions ◽  
Incipient Stage ◽  
Laser Trabeculoplasty

BACKGROUND: Glaucoma remains one of the current problems of modern ophthalmology. The combination of glaucoma and cataract is observed in 1738.6% of cases, and glaucoma with pseudoexfoliative syndrome in 2050% of primary open-angle glaucoma cases. AIM: The aim of this work is to develop an effective and safe technology of complex energetic surgical treatment of the incipient primary open-angle glaucoma stage and cataract on the background of pseudoexfoliation syndrome on the basis of modified laser, hydrodynamic and ultrasound methods use. MATERIALS AND METHODS: 187 patients (187 eyes) with the incipient stage of primary open-angle glaucoma, cataract and pseudoexfoliation syndrome were examined. In the main group (111 eyes), selective laser trabeculoplasty followed by femtosecond laser-assisted cataract surgery with hydrodynamic trabeculocleaning was performed. Patients in the control group (76 eyes), after selective laser trabeculoplasty, underwent phacoemulsification according to the standard technique. RESULTS: The developed technology allowed to reach the hypotensive effect in 35.2% (t=23.0; р 0.001) of baseline intraocular pressure values, of individual intraocular pressure level without adding IOP-lowering medications in 27% of cases, stabilization of visual functions and morphometric indices of the optic disc during 2 years of follow-up in 97.3% of cases unlike the selective laser trabeculoplasty with subsequent phacoemulsification (21.2, 5.3 and 81.6% respectively). The patients of the main group had significantly lower energy expenditure during the stage of phacoemulsification, a lower percentage of postoperative inflammatory reaction was noted, and a persistent hypotensive effect with stabilization of visual functions was achieved based on the results of a two-year follow-up. CONCLUSIONS: Femtosecond laser-assisted phacoemulsification, performed as part of complex treatment in patients with cataract and incipient stage of primary open-angle glaucoma, is a sparing method that minimizes surgical trauma and achieves a persistent hypotensive effect, reduces intraocular pressure to an individual level and stabilizes visual functions in 97.3% of cases.

scholarly journals Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma

2018 ◽  
Vol 27 (12) ◽  
pp. 1037-1041 ◽  
Author(s):  
Pooja Patel ◽  
Alon Harris ◽  
Carol Toris ◽  
Leslie Tobe ◽  
Matthew Lang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Intraocular Pressure ◽  
Sex Hormones ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Ocular Blood Flow ◽  
Open Angle

scholarly journals The experience of the first Russian latanoprost 0.005% (Trilactan) use in the treatment of primary open-angle glaucoma

2018 ◽  
Vol 11 (1) ◽  
pp. 67-70
Author(s):  
Alla O Tatarintseva
Keyword(s):  
Intraocular Pressure ◽  
Adverse Events ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Beta Blockers ◽  
Hypotensive Effect ◽  
Open Angle ◽  
Know How ◽  
Treatment Naïve ◽  
Previously Treated

The problem of the reproduced (generic) and original (branded) medications coexistence on the pharmaceutical market is very relevant for Russia. Numerous polls have shown that very few among patients and even doctors clearly understand the differences between original drugs and generics, nor they know how these drugs are produced, and what advantages and weaknesses they have. Aim. This paper covers the study of Trilactan (0.005% latanoprost, Solopharm, Russia) use in patients with different stages of primary open-angle glaucoma, and includes the analysis of the hypotensive effect and adverse events rate. Material and methods. The study included 47 patients divided into 3 groups. The first group included 17 treatment-naïve patients (32 eyes). The second group included 14 patients (28 eyes) previously treated with latanoprost 0.005% once a day in the evening at least for a month. The third group consisted of 16 patients (32 eyes) treated with beta-blockers or carbonic anhydrase inhibitors, in whom the target level of intraocular pressure had not been reached. All patients received 1 drop of Trilactan every evening; the observation lasted for 3 months. Conclusions. The treatment was well tolerated. The intraocular pressure decrease was observed in all cases (p > 0.05). Local and systemic adverse events under Trilactan treatment did not differ from possible side effects typical to the drugs of this pharmacological group in terms of its type and rate. (For citation: Tatarintseva AO. The experience of the first Russian latanoprost 0.005% (Trilactan) use in the treatment of primary open-angle glaucoma. Ophthalmology Journal. 2018;11(1):67-70. doi: 10.17816/OV11167-70).

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