scholarly journals Role of Hyperinsulinemia in Atherosclerotic Coronary Arterial Disease. Studies of Semi-quantitative Coronary Angiography.

1999 ◽  
Vol 38 (9) ◽  
pp. 691-697 ◽  
Author(s):  
Kazufumi TSUCHIHASHI ◽  
Nobuichi HIKITA ◽  
Mamoru HASE ◽  
Jun AGATA ◽  
Shigeyuki SAITOH ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Quantitative Coronary Angiography ◽  
Arterial Disease ◽  
Coronary Arterial Disease

scholarly journals Brain natriuretic peptide: Diagnostic potential in dogs

2009 ◽  
Vol 63 (5-6) ◽  
pp. 381-392
Author(s):  
Ljubica Spasojevic-Kosic
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Natriuretic Peptides ◽  
Arterial Disease ◽  
Cardiac Insufficiency ◽  
Everyday Clinical Practice ◽  
Coronary Arterial Disease ◽  
Diagnostic Potential ◽  
Adequate Method

The endocrine role of the heart is evident in the secretion of noradrenaline and natriuretic peptides. The secretion of natriuretic peptides presents a useful mechanism for different conditions of cardiac dysfunction. Brain natriuretic peptide (BNP) has been accepted in human cardiology as a biomarker for cardiac insufficiency and coronary arterial disease. The specificity of the BNP structure is specie-specific, so that the testing of diagnostic and prognostic potential in dogs requires the existence of a test that is a homologue for that animal specie. The existence of an adequate method for measuring BNP concentration makes possible its implementation as a screening test in everyday clinical practice. .

Cardiac magnetic resonance in patients with elevated troponin and normal coronary angiography

Heart ◽  
2019 ◽  
Vol 105 (16) ◽  
pp. 1231-1236 ◽  
Author(s):  
Subir Bhatia ◽  
Christopher Anstine ◽  
Allan S Jaffe ◽  
Bernard J Gersh ◽  
Krishnaswamy Chandrasekaran ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Small Area ◽  
Troponin T ◽  
Arterial Disease ◽  
Stress Cardiomyopathy ◽  
Cardiac Biomarkers ◽  
Elevated Troponin ◽  
Coronary Arterial Disease ◽  
Ischaemic Cardiomyopathy ◽  
Single Centre Study

BackgroundInvasive angiography in the setting of cardiac troponin elevation may reveal non-obstructive coronary arteries leading to uncertainty in diagnosis. Cardiac MR (CMR) may aid in diagnosis, however, the spectrum of diagnostic findings in the patient presenting with symptoms of cardiac ischaemia, elevated cardiac biomarkers and a negative invasive coronary angiogram is yet to be completely described.MethodsWe queried the Mayo Clinic, Rochester inpatient record from 1 January 2000 to 31 December 2016 to identify patients who: (1) had an elevated troponin T during admission, (2) underwent coronary angiography within 30 days of troponin T elevation which was considered negative for obstructive coronary arterial disease and (3) underwent CMR within 30 days of troponin T elevation. CMR diagnoses were classified as either (1) myocarditis, (2) small area myocardial infarction, (3) stress cardiomyopathy, (4) non-ischaemic cardiomyopathy or (5) normal.ResultsOf 215 patients, the spectrum of disease seen on CMR was myocarditis (32%), small area infarction (22%), non-ischaemic cardiomyopathy (20%) and stress cardiomyopathy (9.3%).ConclusionIn the largest single-centre study assessing the role of CMR in patients admitted with elevated troponin T with a non-obstructive coronary disease on an angiogram, small area infarction was seen in 22% of patients.

scholarly journals The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Mohsin H. K. Roshan ◽  
Amos Tambo ◽  
Nikolai P. Pace
Keyword(s):  
Adaptor Protein ◽  
Arterial Disease ◽  
Primary Response ◽  
Atheromatous Plaque ◽  
Nf Kappa B ◽  
Coronary Arterial Disease ◽  
Inflammatory Conditions ◽  
Inflammatory Processes ◽  
Molecular Patterns

Toll-like receptors (TLRs) are key players in the pathogenesis of inflammatory conditions including coronary arterial disease (CAD). They are expressed by a variety of immune cells where they recognize pathogen-associated molecular patterns (PAMPs). TLRs recruit adaptor molecules, including myeloid differentiation primary response protein (MYD88) and TIRF-related adaptor protein (TRAM), to mediate activation of MAPKs and NF-kappa B pathways. They are associated with the development of CAD through various mechanisms. TLR4 is expressed in lipid-rich and atherosclerotic plaques. In TLR2−/−and TLR4−/−mice, atherosclerosis-associated inflammation was diminished. Moreover, TLR2 and TLR4 may induce expression of Wnt5a in advanced staged atheromatous plaque leading to activation of the inflammatory processes. TLR9 is activated by CpG motifs in nucleic acids and have been implicated in macrophage activation and the uptake of oxLDL from the circulation. Furthermore, TLR9 also stimulates interferon-α(INF-α) secretion and increases cytotoxic activity of CD4+T-cells towards coronary artery tunica media smooth muscle cells. This review outlines the pathophysiological role of TLR2, TLR4, and TLR9 in atherosclerosis, focusing on evidence from animal models of the disease.

scholarly journals CT-Coronary Angiography

2019 ◽  
Vol 10 (SPL1) ◽  
Author(s):  
Yussri Jemenin
Keyword(s):  
Chest Pain ◽  
Coronary Angiography ◽  
Large Body ◽  
Invasive Procedure ◽  
Arterial Disease ◽  
Ct Coronary Angiography ◽  
Conventional Coronary Angiography ◽  
Conventional Angiography ◽  
Coronary Arterial Disease ◽  
Non Invasive

A large body of literature has demonstrated the ability of coronary computed tomographic (CT) angiography to rule out significant stenosis. This test is a non-invasive alternative to conventional cardiac angiography in the work-up of patients suspected of having coronary artery disease (CAD) and increasingly as an option for the people. A multi-slices Computed Tomography (CT) is able to perform coronary angiography with very fast scanning time within a few seconds. It is an imaging test tool to detect cardiovascular disease in the arteries that supply blood to the heart. It can be used to diagnose the cause of chest pain or other symptoms. Chest pain can be caused by myocardial infarction that may need immediate investigation and accurate diagnosis before any treatment. The procedure can be done as out-patient, convenient, and with very minimal contrast media (Dye) injection. A CT coronary angiography relies on a powerful X-ray machine with multi-detectors and special computer software to produce 2D and 3D images of the heart and its blood vessels. A conventional coronary angiography is an invasive procedure that requires a flexible tube (catheter) to be threaded through the groin or arm to the heart or coronary arteries. CT coronary angiography is an advantage, non-invasive, and the option for the patient who have contraindicated for conventional angiography. But clinically conventional angiography is still the gold standard for detecting coronary arterial disease.

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