scholarly journals Synchronously Multiple Gastric Adenocarcinomas with Intestinal Mucin Phenotype in a Patient not Infected with Helicobacter pylori, Showing a Gastritis-like Appearance

2020 ◽  
Vol 59 (24) ◽  
pp. 3155-3159
Author(s):  
Kenichi Kishimoto ◽  
Kotaro Shibagaki ◽  
Ayako Itawaki ◽  
Shinsaku Tanaka ◽  
Yusuke Takahashi ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Mucin Phenotype ◽  
Gastric Adenocarcinomas ◽  
Intestinal Mucin

scholarly journals Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype

2015 ◽  
Vol 106 (8) ◽  
pp. 951-958 ◽  
Author(s):  
Naohide Oue ◽  
Kazuhiro Sentani ◽  
Naoya Sakamoto ◽  
Wataru Yasui
Keyword(s):  
Gastric Cancer ◽  
Molecular Characteristics ◽  
Mucin Phenotype ◽  
Intestinal Mucin

scholarly journals Gastric foveolar-type adenomas endoscopically showing a raspberry-like appearance in the Helicobacter pylori-uninfected stomach

2019 ◽  
Vol 07 (06) ◽  
pp. E784-E791 ◽  
Author(s):  
Kotaro Shibagaki ◽  
Chika Fukuyama ◽  
Hironobu Mikami ◽  
Daisuke Izumi ◽  
Noritsugu Yamashita ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Narrow Band Imaging ◽  
Past History ◽  
Clinicopathological Characteristics ◽  
Igg Antibody ◽  
Ki 67 ◽  
Mucin Phenotype ◽  
White Light Endoscopy ◽  
Japanese Classification

Abstract Background and study aims Foveolar-type adenoma is described as a very rare tumor that occurs in individuals without Helicobacter pylori (HP) infection and diagnosed as adenocarcinoma in the Japanese Classification of Gastric Carcinoma (JCGC). However, we have frequently encountered patients with foveolar-type adenoma that endoscopically resembles a hyperplastic polyp, suggesting that it has just been overlooked to date. Here, we analyzed clinicopathological characteristics of a special subtype of foveolar-type adenoma showing specific endoscopic findings. Patients and methods From a total of 212 patients with gastric cancer resected during a 22-month period, we enrolled 14 (6.6 %) diagnosed with foveolar-type adenoma (adenocarcinoma in JCGC). HP infection status was determined by eradication history, HP serum IgG antibody level, urea breath test, and endoscopic and histological findings. All lesions were observed using white-light endoscopy and narrow-band imaging with magnification endoscopy (NBIME). Endoscopically resected lesions were histologically examined. Results None of 14 patients had a current or past history of HP infection. All lesions were visualized on non-atrophic gastric mucosa as small reddish protrusions with fine granular surface, showing a raspberry-like appearance. NBIME showed papillary or gyrus-like microstructures with irregular capillary. Lesions were histologically diagnosed as foveolar-type adenoma showing MUC5AC-positive gastric mucin phenotype. Ki-67 was overexpressed (median labeling index 69.9 %, range 28.4 – 92.1 %), though all lesions were an intraepithelial tumor without stromal invasion. p53 over-staining was not seen in any. Conclusions Raspberry-like lesions on non-atrophic gastric mucosa in HP-uninfected individuals should be evaluated for the possibility of a special subtype of foveolar-type adenoma.

CDX2 expression is increased in gastric cancers with less invasiveness and intestinal mucin phenotype

2006 ◽  
Vol 41 (8) ◽  
pp. 880-886 ◽  
Author(s):  
Gwang Ha Kim ◽  
Geun Am Song ◽  
Do Youn Park ◽  
Soo Han Lee ◽  
Dong Hyun Lee ◽  
...  
Keyword(s):  
Mucin Phenotype ◽  
Gastric Cancers ◽  
Cdx2 Expression ◽  
Intestinal Mucin

scholarly journals Opposing Risks of Gastric Cardia and Noncardia Gastric Adenocarcinomas Associated With Helicobacter pylori Seropositivity

2006 ◽  
Vol 98 (20) ◽  
pp. 1445-1452 ◽  
Author(s):  
Farin Kamangar ◽  
Sanford M. Dawsey ◽  
Martin J. Blaser ◽  
Guillermo I. Perez-Perez ◽  
Pirjo Pietinen ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Cardia ◽  
Gastric Adenocarcinomas

Overexpression of KIF11 in Gastric Cancer with Intestinal Mucin Phenotype

Pathobiology ◽  
2016 ◽  
Vol 84 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Takeharu Imai ◽  
Naohide Oue ◽  
Masahiro Nishioka ◽  
Shoichiro Mukai ◽  
Takashi Oshima ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mucin Phenotype ◽  
Intestinal Mucin

scholarly journals Gastric Adenocarcinomas in Central Tunisia: Evolution Specificities through Two Decades and Relation with Helicobacter pylori

Oncology ◽  
2018 ◽  
Vol 95 (2) ◽  
pp. 121-128 ◽  
Author(s):  
Mohamed Amine Elghali ◽  
Amine Gouader ◽  
Rym Bouriga ◽  
Mohamed Mahjoub ◽  
Mohamed Salah Jarrar ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Central Tunisia ◽  
Gastric Adenocarcinomas

Mucin Expression in Gastric Cancer: Reappraisal of Its Clinicopathologic and Prognostic Significance

2013 ◽  
Vol 137 (8) ◽  
pp. 1047-1053 ◽  
Author(s):  
Dae Hwan Kim ◽  
Nari Shin ◽  
Gwang Ha Kim ◽  
Geum Am Song ◽  
Tae-Yong Jeon ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Analysis ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Proportional Hazard ◽  
Poor Prognostic Factor ◽  
Mucin Phenotype ◽  
Gastric Cancers ◽  
Intestinal Mucin ◽  
Mucin Expression

Context.—The clinical validity of mucin expression in gastric cancer is debated. Whereas several reports demonstrate a correlation between mucin expression and prognosis, others deny such an association. Objectives.—This survival analysis study aims to elucidate the prognostic significance of mucin expression in gastric cancer. Design.—A retrospective survival analysis was done with 412 cases of gastric cancer characterized on the basis of MUC immunohistochemistry using MUC2, MUC5AC, MUC6, and CD10 antibodies; the cases were divided into those with a gastric, an intestinal, or a null mucin phenotype based on the predominant mucin. Results.—There was no association between mucin expression and survival when considering overall gastric cancers or the advanced gastric cancer subtype. However, early gastric cancers with a gastric mucin phenotype showed longer survival than those with an intestinal mucin phenotype (P = .01) or a null phenotype (P = .01). In particular, MUC5AC-positive early gastric cancers resulted in longer survival than did those that did not express MUC5AC (P = .009). The loss of MUC5AC expression was identified as an independent, poor prognostic factor in early gastric cancers using the Cox regression proportional hazard model (hazard ratio, 3.50; P = .045). Conclusions.—MUC5AC expression is significantly associated with patient survival and can be used to predict outcomes in the gastric cancers, especially in the early gastric cancers.

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