Production of humanized monoclonal antibodies against Bacillus anthracis and Yersenia pestis for the urgent prophalaxis and therapy of exposed individuals

2011 ◽  
Author(s):  
David M. Robinson
Keyword(s):  
Monoclonal Antibodies ◽  
Bacillus Anthracis ◽  
Humanized Monoclonal Antibodies

Elotuzumab in the treatment of relapsed and refractory multiple myeloma

2021 ◽  
Author(s):  
Sebastian Grosicki ◽  
Martyna Bednarczyk ◽  
Agnieszka Barchnicka ◽  
Olga Grosicka
Keyword(s):  
Multiple Myeloma ◽  
Monoclonal Antibodies ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Clinical Studies ◽  
Mechanisms Of Action ◽  
Incurable Disease ◽  
The Us ◽  
Us Fda ◽  
Humanized Monoclonal Antibodies

Multiple myeloma (MM) is still considered an incurable disease. However, drugs with different mechanisms of action that can improve the efficiency of treatment offer hope. Still, there are concerns about an unacceptable increase in toxicity with such regimens. The results of recently published clinical studies of elotuzumab in combination with lenalidomide/dexamethasone or pomalidomide/dexamethasone confirm previous hopes to improve the effect of that treatment. Humanized monoclonal antibodies aimed at SLAMF7 stimulate natural killer cells to fight against MM cells. Elotuzumab used in combination with lenalidomide/dexamethasone or with pomalidomide/dexamethasone is approved by the US FDA to treat patients with relapsed and/or refractory MM. The article is a summary of the recent knowledge about the possibility of using elotuzumab in the treatment of relapsed and/or refractory MM and shows its potential uses in the future.

Treatment with humanized monoclonal antibodies against CD80 and CD86 combined with sirolimus prolongs renal allograft survival in cynomolgus monkeys1

2003 ◽  
Vol 75 (12) ◽  
pp. 2106-2113 ◽  
Author(s):  
Tudor B??rsan ◽  
Bernard Hausen ◽  
John P. Higgins ◽  
Richard W. Hubble ◽  
Jochen Klupp ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Renal Allograft ◽  
Allograft Survival ◽  
Humanized Monoclonal Antibodies

scholarly journals Stereo-selective binding of monoclonal antibodies to the poly-gamma-d-glutamic acid capsular antigen of Bacillus anthracis

2013 ◽  
Vol 55 (3-4) ◽  
pp. 337-344 ◽  
Author(s):  
Mark A. Hubbard ◽  
Peter Thorkildson ◽  
William H. Welch ◽  
Thomas R. Kozel
Keyword(s):  
Monoclonal Antibodies ◽  
Glutamic Acid ◽  
Bacillus Anthracis ◽  
Selective Binding ◽  
Capsular Antigen
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