Recent Advances in the Discovery and Development of Novel HIV-1 NNRTI Platforms: 2006-2008 Update

2009 ◽  
Vol 16 (22) ◽  
pp. 2876-2889 ◽  
Author(s):  
Peng Zhan ◽  
Xinyong Liu ◽  
Zhenyu Li
Keyword(s):  
2017 ◽  
Vol 12 (2) ◽  
pp. 141-155 ◽  
Author(s):  
Claudia Matteucci ◽  
Sandro Grelli ◽  
Emanuela Balestrieri ◽  
Antonella Minutolo ◽  
Ayele Argaw-Denboba ◽  
...  

Virology ◽  
2008 ◽  
Vol 375 (2) ◽  
pp. 315-320 ◽  
Author(s):  
Victoria R. Polonis ◽  
Bruce K. Brown ◽  
Andrew Rosa Borges ◽  
Susan Zolla-Pazner ◽  
Dimiter S. Dimitrov ◽  
...  

2011 ◽  
Vol 89 (5) ◽  
pp. 429-436 ◽  
Author(s):  
Natalia Papeta ◽  
Roel Sterken ◽  
Krzysztof Kiryluk ◽  
Robert Kalyesubula ◽  
Ali G. Gharavi

2013 ◽  
Vol 21 (3) ◽  
pp. 329-355 ◽  
Author(s):  
Yu’ning Song ◽  
Zengjun Fang ◽  
Peng Zhan ◽  
Xinyong Liu
Keyword(s):  

2004 ◽  
Vol 2 (4) ◽  
pp. 357-376 ◽  
Author(s):  
Antonella Caputo ◽  
Riccardo Gavioli ◽  
Barbara Ensoli
Keyword(s):  

2008 ◽  
Vol 8 (12) ◽  
pp. 1243-1251 ◽  
Author(s):  
Fang Yu ◽  
Xinyong Liu ◽  
Peng Zhan ◽  
Erik De Clercq
Keyword(s):  
Rnase H ◽  

2012 ◽  
Vol 9 (1) ◽  
pp. 20-26
Author(s):  
Norihito Kawashita ◽  
Yu-Shi Tian ◽  
U. Chandimal de Silva ◽  
Kousuke Okamoto ◽  
Tatsuya Takagi

2011 ◽  
Vol 18 (3) ◽  
pp. 359-376 ◽  
Author(s):  
Xuwang Chen ◽  
Peng Zhan ◽  
Dongyue Li ◽  
Erik De Clercq ◽  
Xinyong Liu
Keyword(s):  

2021 ◽  
Vol 28 ◽  
Author(s):  
Chao Zhang ◽  
Qian Xie ◽  
Chi Cheong Wan ◽  
Zhe Jin ◽  
Chun Hu

: HIV-1 integrase catalyzed the insertion of the viral DNA into the genome of human cells in the process of retrotranscription. Integrase is an attractive target for HIV-1 treatment due to the lack of its homologue in human cells and its vital role in HIV-1 replication. Although a major progress about the development of HIV-1 integrase inhibitors has been made, some thorny problems, such as the drug resistance, led to the further study of HIV-1 integrase inhibitors. This review briefly discussed the structure, function and mechanism of catalysis of HIV-1 integrase and made a further conclusion for recent advances in small-molecule inhibitors of HIV-1 integrase.


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