Diethylphosphoryl-OxymaB (DEPO-B) as a Solid Coupling Reagent for Amide Bond Formation

2018 ◽  
Vol 16 (1) ◽  
pp. 30-33
Author(s):  
Ashish Kumar ◽  
Yahya E. Jad ◽  
Ayman El-Faham ◽  
Beatriz G. de la Torre ◽  
Fernando Albericio
Keyword(s):  
Bond Formation ◽  
Hydrolytic Stability ◽  
Solid Material ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Coupling Reagent

A new phosphonium based coupling reagent DEPO-B has been synthesized from 5- (hydroxyimino)-1,3-dimethylpyrimidine-2,4,6 (1H,3H,5H)-trione (Oxyma B) and diethyl chlorophosphate in presence of base. It is a solid material and the hydrolytic stability and solubility was evaluated for confirming its capability for usage in automated peptide synthesizer.

A computational study on the mechanism of ynamide-mediated amide bond formation from carboxylic acids and amines

2017 ◽  
Vol 15 (30) ◽  
pp. 6367-6374 ◽  
Author(s):  
Song-Lin Zhang ◽  
Hai-Xing Wan ◽  
Zhu-Qin Deng
Keyword(s):  
Reaction Mechanism ◽  
Carboxylic Acids ◽  
Computational Study ◽  
Bond Formation ◽  
Amide Bond ◽  
Reactivity Pattern ◽  
Amide Bond Formation ◽  
Coupling Reagent ◽  
Catalytic Effects ◽  
Acid Substrate

A detailed computational study is presented on the reaction mechanism of ynamide-mediated condensation of carboxylic acids with amines to produce amides, which elucidates the reactivity pattern of the coupling reagent ynamide and discloses crucial bifunctional catalytic effects of the carboxylic acid substrate during aminolysis.

Diphenylsilane as a coupling reagent for amide bond formation

2017 ◽  
Vol 19 (21) ◽  
pp. 5060-5064 ◽  
Author(s):  
Morgane Sayes ◽  
André B. Charette
Keyword(s):  
Carboxylic Acids ◽  
Bond Formation ◽  
Direct Coupling ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Coupling Reagent

A simple amidation procedure enabling the direct coupling of carboxylic acids to amines using one equivalent of diphenysilane is reported.

2‐Chloroimidazolium Chloride as a Coupling Reagent for Amide Bond Formation

2020 ◽  
Vol 5 (15) ◽  
pp. 4596-4600
Author(s):  
Jie Han ◽  
Yingjie Sun ◽  
Zhifan Wang ◽  
Qingfei Huang ◽  
Jin Zhu ◽  
...  
Keyword(s):  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Coupling Reagent

Oligo(5-amino-N-acylanthranilic acids): Amide Bond Formation without Coupling Reagent and Folding upon Binding Anions

2020 ◽  
Vol 22 (19) ◽  
pp. 7496-7501
Author(s):  
Ruikai Cao ◽  
Robert B. Rossdeutcher ◽  
Xiangxiang Wu ◽  
Bing Gong
Keyword(s):  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Coupling Reagent

A Review of Amide Bond Formation in Microwave Organic Synthesis

2014 ◽  
Vol 11 (4) ◽  
pp. 592-604 ◽  
Author(s):  
Natalia Lukasik ◽  
Ewa Wagner-Wysiecka
Keyword(s):  
Organic Synthesis ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation
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