scholarly journals Morphologic Changes in Patient with Drusen and Drusenoid Pigment Epithelial Detachment after Intravitreal Ranibizumab for Choroidal Neovascular Membrane : A Case Report

2016 ◽  
Vol 10 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Sukjin Kim ◽  
Jeongjae Oh ◽  
Kiseok Kim
Keyword(s):  
Visual Acuity ◽  
Case Report ◽  
Age Related Macular Degeneration ◽  
Pigment Epithelial Detachment ◽  
Choroidal Neovascular Membrane ◽  
Intravitreal Ranibizumab ◽  
Pigment Epithelial ◽  
Age Related ◽  
The Right ◽  
Morphologic Changes

The authors present a case of morphologic changes of drusen and drusenoid pigment epithelial detachment (DPED) after treating choroidal neovascularization (CNV) using ranibizumab in age-related macular degeneration (AMD). A 71-year-old woman has noticed mild visual acuity deterioration in the right eye for several months. She was presented with some drusen and DPED associated with CNV. This patient was given intravitreal injection of 0.5 mg of ranibizumab five times at monthly intervals for treating CNV. DPED in the temporal and drusen in the superior to macula were diminished, which continued up to 2 months. Intravitreal ranibizumab injection may have influenced with diminishment of drusen and DPED. After 2 months, CNV was recurred.

Two-Year Course of Subfoveal Pigment Epithelial Detachment in Eyes with Age-Related Macular Degeneration and Visual Acuity Better than 20/40

2012 ◽  
Vol 228 (2) ◽  
pp. 102-109 ◽  
Author(s):  
Takayuki Baba ◽  
Masayasu Kitahashi ◽  
Mariko Kubota-Taniai ◽  
Toshiyuki Oshitari ◽  
Shuichi Yamamoto
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Pigment Epithelial Detachment ◽  
Pigment Epithelial ◽  
Age Related ◽  
Better Than

scholarly journals Polypoidal Choroidal Vasculopathy

2021 ◽  
Vol 37 (2) ◽  
Author(s):  
Sana Nadeem
Keyword(s):  
Polypoidal Choroidal Vasculopathy ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Pigment Epithelial Detachment ◽  
Choroidal Neovascular Membrane ◽  
Hard Exudates ◽  
Pigment Epithelial ◽  
Age Related ◽  
Choroidal Vasculopathy

A 76-year-old, hypertensive lady, presented with a three year history of gradual decrease in vision in her right eye. Examination revealed a large, bullous, serous pigment epithelial detachment (PED) of right fovea, a choroidal neovascular membrane, clusters of hard exudates, drusen and surrounding, multifocal, small PEDs. The left eye showed a series of small PEDs mostly on the inferior macula, pigmentary disturbance of the retinal pigment epithelium and scant hard exudates. A diagnosis of Polypoidal choroidal vasculopathy was made. We decided to treat her with intravitreal Bevacizumab injections in her right eye. At 18 months of follow up, her PEDs had resolved and visual acuity had improved from 6/60 OD to 6/36. Key Words:  Polypoidal Choroidal Vasculopathy, Age Related Macular Degeneration, Pigment Epithelial Detachment, Choroidal Neovascular Membrane.

scholarly journals Morphological features of choroidal neovascular membranes in age-related macular degeneration complicated by high pigment epithelial detachment

2015 ◽  
Vol 96 (3) ◽  
pp. 364-368
Author(s):  
U R Altynbaev ◽  
O I Lebedeva
Keyword(s):  
Macular Degeneration ◽  
Pigment Epithelium ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Pigment Epithelial Detachment ◽  
Choroidal Neovascular Membrane ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Pigment Epithelial ◽  
Age Related

Aim. To study the morphological features of choroidal neovascular membranes in patients with wet age-related macular degeneration, complicated by high pigment epithelial detachment. Methods. The study enrolled 10 patients with wet age-related macular degeneration, who underwent vitrectomy with choroidal neovascular membranes removal, including 4 patients with occult choroidal neovascularization and 6 patients with classic choroidal neovascular membrane. Results. Histologic pattern consisting of pigmented epithelium cells layer with Bruch’s membrane, fibrovascular membrane, photoreceptors segments layer and, in some of the cases, choroid fragments, was discovered in tissue specimens of patients with classic choroidal neovascular membrane. Histologic pattern of choroidal neovascular membrane in patients with occult choroidal neovascularization also consisted of pigment epithelium cells layer with Bruch’s membrane, fibrotic neovascular membrane itself and photoreceptors segments layer. Pigment epithelium cell layer, in contrast to the control group, had apparent signs of hyperplasia. Average thickness of pigment layer of the retina was 16.08±4.64 μm in patients with high pigment epithelial detachment, by 30% higher compared to the control group (11.22±3.38 μm, р <0.05). Mean Bruch’s membrane thickness was 6.7±0.19 μm in the main group, which also exceeded the similar values in the control group (5.7±3.8 μm, р <0.05). Histochemical studies revealed qualitative differences between the study groups in the levels of collagen types I and III. Glycosaminoglycans, in contrast, were detected only in the group with classic choroidal neovascular membrane. Conclusion. In patients with occult choroidal neovascular membrane complicated by high pigment epithelial detachment, Bruch’s membrane thickening was found due to collagen type 1 deposits on the outer surface, which caused a local hydrodynamics alterations and influences the bioavailability of medications.

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