Michael Addition of Imidazole to α, β -Unsaturated Carbonyl/Cyano Compound
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Introduction: Aza-Michael addition is an important reaction for carbon-nitrogen bond formation in synthetic organic chemistry. Expalantion: Conjugate addition of imidazole to α,β-unsaturated carbonyl/cyano compounds provides significant numbers of the biologically and synthetically interesting products, such as β-amino acids and β-lactams, which have attracted great attention for their use as key intermediates of anticancer agents, antibiotics and other drugs. Conclusion: This review addresses most significant method for the synthesis of N-substituted imidazole derivatives following Michael addition reaction of imidazole to α,β-unsaturated carbonyl/cyano compounds using ionic liquid/base/acid/enzyme as catalysts from year 2007-2017.
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2021 ◽
Vol 2021
(37)
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pp. 5105-5105
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2009 ◽
Vol 6
(2)
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pp. 151-155
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1999 ◽
Vol 10
(4)
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pp. 713-719
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2020 ◽
Vol 22
(20)
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pp. 11529-11536
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