scholarly journals Repeated Injection of Contrast Medium Inducing Dysfunction of the Blood-Brain Barrier

2013 ◽  
Vol 53 (1) ◽  
pp. 34-36 ◽  
Author(s):  
Tomonori IWATA ◽  
Takahisa MORI ◽  
Hiroyuki TAJIRI ◽  
Yuichi MIYAZAKI ◽  
Masahito NAKAZAKI
Keyword(s):  
Contrast Medium ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Repeated Injection ◽  
Blood Brain

Local Blood-Brain Barrier Penetration following Systemic Contrast Medium Administration

1988 ◽  
Vol 29 (2) ◽  
pp. 237-242 ◽  
Author(s):  
R. Utz ◽  
S. E. Ekholm ◽  
L. Isaac ◽  
M. Sands ◽  
D. Fonte
Keyword(s):  
Contrast Medium ◽  
Blood Brain Barrier ◽  
Prolonged Exposure ◽  
Elevated Serum ◽  
Cortical Blindness ◽  
High Serum ◽  
Brain Barrier ◽  
Laboratory Model ◽  
Blood Brain ◽  
The Impact

The present study was initiated by a severe complication in a patient with renal dysfunction who developed cortical blindness and weakness of her left extremities 30 hours following renal and abdominal angiography. To evaluate the impact of prolonged high serum concentrations of contrast medium (CM) this clinical situation was simulated in a laboratory model using sheep with elevated serum levels of contrast medium maintained for 48 hours. The experimental data did not support the theory that the prolonged exposure to high circulating levels of contrast medium (4 ml/kg body weight of meglumine diatrizoate 60%) is sufficient alone to cause penetration of the blood-brain barrier.

Local blood-brain barrier penetration following systemic contrast medium administration

1988 ◽  
Vol 29 (2) ◽  
pp. 237-242 ◽  
Author(s):  
R. Utz ◽  
S. E. Ekholm ◽  
L. Isaac ◽  
M. Sands ◽  
D. Fonte
Keyword(s):  
Contrast Medium ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Contrast Medium Administration ◽  
Barrier Penetration

Disruption of the Blood-Brain Barrier Caused by Nonionic Contrast Medium used for Abdominal Angiography

1989 ◽  
Vol 13 (5) ◽  
pp. 893-895 ◽  
Author(s):  
Hiroshi Okazaki ◽  
Katsuaki Tanaka ◽  
Toshihiro Shishido ◽  
Hajime Nagase ◽  
Masato Hoshino ◽  
...  
Keyword(s):  
Contrast Medium ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Abdominal Angiography ◽  
Blood Brain ◽  
Nonionic Contrast Medium

Conformationally Constrained Peptide Drugs Targeted at the Blood-Brain Barrier

1995 ◽  
Author(s):  
Thomas P. Davis ◽  
Thomas J. Abbruscato ◽  
Elizabeth Brownson ◽  
Victor J. Hruby
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Peptide Drugs ◽  
Conformationally Constrained ◽  
Blood Brain
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