scholarly journals A case of anti-PL-7 antibody positive polymyositis with thrombotic microangiopathy

2017 ◽  
Vol 40 (6) ◽  
pp. 450-455 ◽  
Author(s):  
Masao TAMURA ◽  
Masayasu KITANO ◽  
Kouta AZUMA ◽  
Kazuyuki TSUBOI ◽  
Takeo ABE ◽  
...  
Keyword(s):  
Thrombotic Microangiopathy

Complement-mediated thrombotic microangiopathy or sepsis with disseminated intravascular coagulation -what is primary?

2019 ◽  
Vol 23 (3) ◽  
pp. 78-83
Author(s):  
F. U. Dzgoeva ◽  
N. L. Kozlovskaya ◽  
T. L. Bestaeva ◽  
A. M. Kuchieva ◽  
G. G. Bekuzarova
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Thrombotic Microangiopathy ◽  
Intravascular Coagulation

scholarly journals Thrombotic microangiopathy in dasatinib-treated patients with chronic myeloid leukemia

2019 ◽  
Vol 4 (1-2) ◽  
pp. 41-45 ◽  
Author(s):  
Takeo Koshida ◽  
Sylvia Wu ◽  
Hitoshi Suzuki ◽  
Rimda Wanchoo ◽  
Vanesa Bijol ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Tyrosine Kinase Inhibitors ◽  
Thrombotic Microangiopathy ◽  
Myeloid Leukemia ◽  
Kinase Inhibitors ◽  
Kidney Biopsy ◽  
Kinase Inhibitor ◽  
Target Effect

Dasatinib is the second-generation tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia. Proteinuria has been reported with this agent. We describe two kidney biopsy–proven cases of dasatinib-induced thrombotic microangiopathy that responded to stoppage of dasatinib and using an alternate tyrosine kinase inhibitor. Certain specific tyrosine kinase inhibitors lead to endothelial injury and renal-limited thrombotic microangiopathy. Hematologists and nephrologists need to be familiar with this off-target effect of dasatinib.

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