scholarly journals Correction: Effect of Physician-Pharmacist Participation in the Management of Ambulatory Cancer Pain Through a Digital Health Platform: Randomized Controlled Trial

10.2196/33223 ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. e33223
Author(s):  
Lu Zhang ◽  
Howard L McLeod ◽  
Ke-Ke Liu ◽  
Wen-Hui Liu ◽  
Hang-Xing Huang ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cancer Pain ◽  
Digital Health ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Correction Effect

scholarly journals Efficacy of a combination of hypnosis and transcutaneous electrical nerve stimulation for chronic non‐cancer pain: A randomized controlled trial

2021 ◽  
Author(s):  
Louise Tonye‐Geoffroy ◽  
Stéphanie Mauboussin Carlos ◽  
Sophie Tuffet ◽  
Hélène Fromentin ◽  
Laurence Berard ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cancer Pain ◽  
Nerve Stimulation ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Controlled Trial ◽  
Electrical Nerve Stimulation ◽  
Randomized Controlled

A Pain Education Program for chronic cancer pain patients: follow-up results from a randomized controlled trial

Pain ◽  
1997 ◽  
Vol 73 (1) ◽  
pp. 55-69 ◽  
Author(s):  
Rianne de Wit ◽  
Frits van Dam ◽  
Linda Zandbelt ◽  
Anneke van Buuren ◽  
Karin van der Heijden ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cancer Pain ◽  
Education Program ◽  
Controlled Trial ◽  
Pain Education ◽  
Randomized Controlled ◽  
Chronic Cancer Pain ◽  
Pain Patients

scholarly journals Research and Implementation Lessons Learned From a Youth-Targeted Digital Health Randomized Controlled Trial (the ARMADILLO Study)

10.2196/13005 ◽  
2019 ◽  
Vol 7 (8) ◽  
pp. e13005
Author(s):  
Lianne Gonsalves ◽  
Winnie Wangari Njeri ◽  
Megan Schroeder ◽  
Jefferson Mwaisaka ◽  
Peter Gichangi
Keyword(s):  
Randomized Controlled Trial ◽  
Digital Health ◽  
Controlled Trial ◽  
Text Message ◽  
Health Interventions ◽  
World Health ◽  
Intervention Period ◽  
Implementation Challenges ◽  
Randomized Controlled ◽  
Client Side

Background Evidence is lacking on the efficacy of sexual and reproductive health (SRH) communication interventions for youth (aged 15-24 years), especially from low- and middle-income countries. Therefore, the World Health Organization initiated the Adolescent/Youth Reproductive Mobile Access and Delivery Initiative for Love and Life Outcomes (ARMADILLO) program, a free, menu-based, on-demand text message (SMS, short message service) platform providing validated SRH content developed in collaboration with young people. A randomized controlled trial (RCT) assessing the effect of the ARMADILLO intervention on SRH-related outcomes was implemented in Kwale County, Kenya. Objective This paper describes the implementation challenges related to the RCT, observed during enrollment and the intervention period, and their implications for digital health researchers and program implementers. Methods This was an open, three-armed RCT. Following completion of a baseline survey, participants were randomized into the ARMADILLO intervention (arm 1), a once-a-week contact SMS text message (arm 2), or usual care (arm 3, no intervention). The intervention period lasted seven weeks, after which participants completed an endline survey. Results Two study team decisions had significant implications for the success of the trial’s enrollment and intervention implementation: a hands-off participant recruitment process and a design flaw in an initial language selection menu. As a result, three weeks after recruitment began, 660 participants had been randomized; however, 107 (53%) participants in arm 1 and 136 (62%) in arm 2 were “stuck” at the language menu. The research team called 231 of these nonengaging participants and successfully reached 136 to learn reasons for nonengagement. Thirty-two phone numbers were found to be either not linked to our participants (a wrong number) or not in their primary possession (a shared phone). Among eligible participants, 30 participants indicated that they had assumed the introductory message was a scam or spam. Twenty-seven participants were confused by some aspect of the system. Eleven were apathetic about engaging. Twenty-four nonengagers experienced some sort of technical issue. All participants eventually started their seven-week study period. Conclusions The ARMADILLO study’s implementation challenges provide several lessons related to both researching and implementing client-side digital health interventions, including (1) have meticulous phone data collection protocols to reduce wrong numbers, (2) train participants on the digital intervention in efficacy assessments, and (3) recognize that client-side digital health interventions have analog discontinuation challenges. Implementation lessons were (1) determine whether an intervention requires phone ownership or phone access, (2) digital health campaigns need to establish a credible presence in a busy digital space, and (3) interest in a service can be sporadic or fleeting. Clinical Trial International Standard Randomized Controlled Trial Number (ISRCTN): 85156148; http://www.isrctn. com/ISRCTN85156148

Muscle function following testosterone replacement in men on opioid therapy for chronic non‐cancer pain ‐ a randomized controlled trial

Andrology ◽  
2021 ◽  
Author(s):  
Mikkel Iwanoff Kolind ◽  
Louise Lehmann Christensen ◽  
Paolo Caserotti ◽  
Marianne Skovsager Andersen ◽  
Dorte Glintborg
Keyword(s):  
Randomized Controlled Trial ◽  
Cancer Pain ◽  
Muscle Function ◽  
Controlled Trial ◽  
Opioid Therapy ◽  
Testosterone Replacement ◽  
Randomized Controlled

Electroacupuncture treatment for pancreatic cancer pain: A randomized controlled trial

Pancreatology ◽  
2013 ◽  
Vol 13 (6) ◽  
pp. 594-597 ◽  
Author(s):  
Hao Chen ◽  
Tang-Yi Liu ◽  
Le Kuai ◽  
Ji Zhu ◽  
Cai-Jun Wu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Randomized Controlled Trial ◽  
Cancer Pain ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Electroacupuncture Treatment

scholarly journals Minimally Invasive Cordotomy for Refractory Cancer Pain: A Randomized Controlled Trial

2019 ◽  
Vol 24 (7) ◽  
Author(s):  
Ashwin Viswanathan ◽  
Aditya Vedantam ◽  
Kenneth R. Hess ◽  
Jewel Ochoa ◽  
Patrick M. Dougherty ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Minimally Invasive ◽  
Cancer Pain ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals Track: A randomized controlled trial of a digital health obesity treatment intervention for medically vulnerable primary care patients

2016 ◽  
Vol 48 ◽  
pp. 12-20 ◽  
Author(s):  
Perry Foley ◽  
Dori Steinberg ◽  
Erica Levine ◽  
Sandy Askew ◽  
Bryan C. Batch ◽  
...  
Keyword(s):  
Primary Care ◽  
Randomized Controlled Trial ◽  
Digital Health ◽  
Controlled Trial ◽  
Obesity Treatment ◽  
Treatment Intervention ◽  
Randomized Controlled ◽  
Primary Care Patients

scholarly journals A Randomized Controlled Trial of a Standardized Educational Intervention for Patients with Cancer Pain

2010 ◽  
Vol 40 (1) ◽  
pp. 49-59 ◽  
Author(s):  
Melanie R. Lovell ◽  
Peta M. Forder ◽  
Martin R. Stockler ◽  
Phyllis Butow ◽  
Esther M. Briganti ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cancer Pain ◽  
Educational Intervention ◽  
Controlled Trial ◽  
Patients With Cancer ◽  
Randomized Controlled

scholarly journals Patient training in cancer pain management using integrated print and video materials: A multisite randomized controlled trial☆

Pain ◽  
2008 ◽  
Vol 135 (1) ◽  
pp. 175-186 ◽  
Author(s):  
Karen L. Syrjala ◽  
Janet R. Abrams ◽  
Nayak L. Polissar ◽  
Jennifer Hansberry ◽  
Jeanne Robison ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Pain Management ◽  
Cancer Pain ◽  
Controlled Trial ◽  
Cancer Pain Management ◽  
Randomized Controlled

scholarly journals Early Signs Monitoring to Prevent Relapse in Psychosis and Promote Well-Being, Engagement, and Recovery: Protocol for a Feasibility Cluster Randomized Controlled Trial Harnessing Mobile Phone Technology Blended With Peer Support

10.2196/15058 ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. e15058 ◽  
Author(s):  
Andrew Gumley ◽  
Simon Bradstreet ◽  
John Ainsworth ◽  
Stephanie Allan ◽  
Mario Alvarez-Jimenez ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Digital Health ◽  
Controlled Trial ◽  
Well Being ◽  
Service Users ◽  
Main Trial ◽  
Definitive Trial ◽  
Randomized Controlled ◽  
Cluster Randomized

Background Relapse in schizophrenia is a major cause of distress and disability and is predicted by changes in symptoms such as anxiety, depression, and suspiciousness (early warning signs [EWSs]). These can be used as the basis for timely interventions to prevent relapse. However, there is considerable uncertainty regarding the implementation of EWS interventions. Objective This study was designed to establish the feasibility of conducting a definitive cluster randomized controlled trial comparing Early signs Monitoring to Prevent relapse in psychosis and prOmote Well-being, Engagement, and Recovery (EMPOWER) against treatment as usual (TAU). Our primary outcomes are establishing parameters of feasibility, acceptability, usability, safety, and outcome signals of a digital health intervention as an adjunct to usual care that is deliverable in the UK National Health Service and Australian community mental health service (CMHS) settings. We will assess the feasibility of candidate primary outcomes, candidate secondary outcomes, and candidate mechanisms for a definitive trial. Methods We will randomize CMHSs to EMPOWER or TAU. We aim to recruit up to 120 service user participants from 8 CMHSs and follow them for 12 months. Eligible service users will (1) be aged 16 years and above, (2) be in contact with local CMHSs, (3) have either been admitted to a psychiatric inpatient service or received crisis intervention at least once in the previous 2 years for a relapse, and (4) have an International Classification of Diseases-10 diagnosis of a schizophrenia-related disorder. Service users will also be invited to nominate a carer to participate. We will identify the feasibility of the main trial in terms of recruitment and retention to the study and the acceptability, usability, safety, and outcome signals of the EMPOWER intervention. EMPOWER is a mobile phone app that enables the monitoring of well-being and possible EWSs of relapse on a daily basis. An algorithm calculates changes in well-being based on participants’ own baseline to enable tailoring of well-being messaging and clinical triage of possible EWSs. Use of the app is blended with ongoing peer support. Results Recruitment to the trial began September 2018, and follow-up of participants was completed in July 2019. Data collection is continuing. The database was locked in July 2019, followed by analysis and disclosing of group allocation. Conclusions The knowledge gained from the study will inform the design of a definitive trial including finalizing the delivery of our digital health intervention, sample size estimation, methods to ensure successful identification, consent, randomization, and follow-up of participants, and the primary and secondary outcomes. The trial will also inform the final health economic model to be applied in the main trial. Trial Registration International Standard Randomized Controlled Trial Number (ISRCTN): 99559262; http://isrctn.com/ISRCTN99559262 International Registered Report Identifier (IRRID) DERR1-10.2196/15058

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