scholarly journals The National Patient-Centered Clinical Research Network (PCORnet) Bariatric Study Cohort: Rationale, Methods, and Baseline Characteristics

2017 ◽  
Vol 6 (12) ◽  
pp. e222 ◽  
Author(s):  
Sengwee Toh ◽  
Laura J Rasmussen-Torvik ◽  
Emily E Harmata ◽  
Roy Pardee ◽  
Rosalinde Saizan ◽  
...  
Keyword(s):  
Clinical Research ◽  
Research Network ◽  
Study Cohort ◽  
Patient Centered ◽  
Clinical Research Network ◽  
National Patient ◽  
Baseline Characteristics

Understanding the Bariatric Patient Perspective in the National Patient-Centered Clinical Research Network (PCORnet) Bariatric Study

2020 ◽  
Vol 30 (5) ◽  
pp. 1837-1847
Author(s):  
Karen J. Coleman ◽  
David G. Schlundt ◽  
Kemberlee R. Bonnet ◽  
Kimberly J. Holmquist ◽  
Jennifer Dunne ◽  
...  
Keyword(s):  
Clinical Research ◽  
Patient Perspective ◽  
Research Network ◽  
Bariatric Patient ◽  
Patient Centered ◽  
Clinical Research Network ◽  
National Patient

Validation of Cardiovascular End Points Ascertainment Leveraging Multisource Electronic Health Records Harmonized Into a Common Data Model in the ADAPTABLE Randomized Clinical Trial

2021 ◽  
Author(s):  
Guillaume Marquis-Gravel ◽  
Bradley G. Hammill ◽  
Hillary Mulder ◽  
Matthew T. Roe ◽  
Holly R. Robertson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Positive Predictive Value ◽  
Clinical Research ◽  
Predictive Value ◽  
Research Network ◽  
Common Data Model ◽  
Patient Centered ◽  
End Points ◽  
Clinical Research Network ◽  
National Patient

Background: The ADAPTABLE trial (Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness) is the first randomized trial conducted within the National Patient-Centered Clinical Research Network to use the electronic health record data formatted into a common data model as the primary source of end point ascertainment, without confirmation by standard adjudication. The objective of this prespecified study is to assess the validity of nonfatal end points captured from the National Patient-Centered Clinical Research Network, using traditional blinded adjudication as the gold standard. Methods: A total of 15 076 participants with established atherosclerotic cardiovascular disease were randomized to two doses of aspirin (81 mg and 325 mg once daily). Nonfatal end points (hospitalization for nonfatal myocardial infarction, nonfatal stroke, and major bleeding requiring transfusion of blood products) were captured with the use of programming algorithms applied to National Patient-Centered Clinical Research Network data. A random subset of end points was independently reviewed by a disease-specific expert adjudicator. The positive predictive value of the programming algorithms were calculated separately for end points listed as primary and as nonprimary diagnoses. Results: A total of 225 end points were identified (91 myocardial infarction events, 89 stroke events, and 45 bleeding events), including 142 (63%) that were listed as primary diagnoses. Complete source documents were missing for 14% of events. The positive predictive value were 90%, 72%, and 93% for hospitalizations for myocardial infarction, stroke, and major bleeding, respectively, as compared to adjudication. When only primary diagnoses were considered, positive predictive value were 93%, 91%, and 97%, respectively. When only nonprimary diagnoses were considered, positive predictive value were 82%, 36%, and 71%. Conclusions: As compared with blinded adjudication, clinical end point ascertainment from queries of the National Patient-Centered Clinical Research Network distributed harmonized data was valid to identify hospitalizations for myocardial infarction in ADAPTABLE. The proportion of contradicted events was high for hospitalizations for bleeding and strokes when nonprimary diagnoses were analyzed, but not when only primary diagnoses were considered.

scholarly journals Launching PCORnet, a national patient-centered clinical research network

2014 ◽  
Vol 21 (4) ◽  
pp. 578-582 ◽  
Author(s):  
R. L. Fleurence ◽  
L. H. Curtis ◽  
R. M. Califf ◽  
R. Platt ◽  
J. V. Selby ◽  
...  
Keyword(s):  
Clinical Research ◽  
Research Network ◽  
Patient Centered ◽  
Clinical Research Network ◽  
National Patient

scholarly journals Correction to: Understanding the Bariatric Patient Perspective in the National Patient-Centered Clinical Research Network (PCORnet) Bariatric Study

2020 ◽  
Vol 30 (5) ◽  
pp. 1848-1848
Author(s):  
Karen J. Coleman ◽  
◽  
David G. Schlundt ◽  
Kemberlee R. Bonnet ◽  
Kimberly J. Holmquist ◽  
...  
Keyword(s):  
Clinical Research ◽  
Patient Perspective ◽  
Research Network ◽  
Bariatric Patient ◽  
Patient Centered ◽  
Clinical Research Network ◽  
National Patient

scholarly journals Evaluating Foundational Data Quality in the National Patient-Centered Clinical Research Network (PCORnet®)

2018 ◽  
Vol 6 (1) ◽  
pp. 3 ◽  
Author(s):  
Laura Goettinger Qualls ◽  
Thomas A. Phillips ◽  
Bradley G. Hammill ◽  
James Topping ◽  
Darcy M. Louzao ◽  
...  
Keyword(s):  
Clinical Research ◽  
Data Quality ◽  
Research Network ◽  
Patient Centered ◽  
Clinical Research Network ◽  
National Patient

scholarly journals Multistakeholder Engagement in PCORnet, the National Patient-Centered Clinical Research Network

Medical Care ◽  
2018 ◽  
Vol 56 ◽  
pp. S4-S5 ◽  
Author(s):  
Joe V. Selby ◽  
Claudia Grossman ◽  
Maryan Zirkle ◽  
Shayna Barbash
Keyword(s):  
Clinical Research ◽  
Research Network ◽  
Patient Centered ◽  
Clinical Research Network ◽  
National Patient

scholarly journals Interventions and Operations 5 Years After Bariatric Surgery in a Cohort From the US National Patient-Centered Clinical Research Network Bariatric Study

JAMA Surgery ◽  
2020 ◽  
Vol 155 (3) ◽  
pp. 194 ◽  
Author(s):  
Anita Courcoulas ◽  
R. Yates Coley ◽  
Jeanne M. Clark ◽  
Corrigan L. McBride ◽  
Elizabeth Cirelli ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Clinical Research ◽  
Research Network ◽  
Patient Centered ◽  
Clinical Research Network ◽  
The Us ◽  
National Patient

1643-P: Prevalence of Diabetes Medication Regimens in PCORnet, the National Patient-Centered Clinical Research Network

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1643-P
Author(s):  
KATHERINE N. BACHMANN ◽  
CHRISTIANNE ROUMIE ◽  
ANDREW D. WIESE ◽  
CARLOS G. GRIJALVA ◽  
JOHN B. BUSE ◽  
...  
Keyword(s):  
Clinical Research ◽  
Research Network ◽  
Patient Centered ◽  
Diabetes Medication ◽  
Clinical Research Network ◽  
National Patient

scholarly journals Diabetes medication regimens and patient clinical characteristics in the national patient‐centered clinical research network, PCORnet

2020 ◽  
Vol 8 (5) ◽  
Author(s):  
Katherine N. Bachmann ◽  
Christianne L. Roumie ◽  
Andrew D. Wiese ◽  
Carlos G. Grijalva ◽  
John B. Buse ◽  
...  
Keyword(s):  
Clinical Research ◽  
Clinical Characteristics ◽  
Research Network ◽  
Patient Centered ◽  
Diabetes Medication ◽  
Clinical Research Network ◽  
National Patient
Sign in / Sign up

Export Citation Format

Share Document