scholarly journals DEVELOPMENT OF A SENSOR BY ELECTRO-POLYMERIZATION OF ERICHROME BLACK-T ON GLASSY CARBON ELECTRODE AND DETERMINATION OF AN ANTI-INFLAMMATORY DRUG DICLOFENAC

2018 ◽  
pp. 81-87
Author(s):  
Rohini M. Hanabaratti ◽  
Jayant I. Gowda ◽  
Suresh M. Tuwar
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Carbon Electrode ◽  
Pharmaceutical Dosage Form ◽  
Inflammatory Drug ◽  
Voltammetric Detection ◽  
Scan Rate ◽  
Electro Oxidation ◽  
Anti Inflammatory

Objective: The aim of this study was to develop a simple, reliable voltammetric method and its validation for determination of nonsteroidal anti-inflammatory drug diclofenac (DFC). Methods: The proposed method was based on electro-oxidation of DFC at poly (erichrome black T) modified glassy carbon electrode (PEBT/GCE) in 0.2 M phosphate buffer solution of pH 7.0. Cyclic voltammetry and differential pulse voltammetric techniques were employed to study electro-oxidation behavior. Under the optimal conditions, variations of EBT concentration, effect of pH, scan rate on the oxidation of DFC was studied. Results: A well-defined oxidation peak at about +0.59 V vs. standard calomel electrode was observed for voltammetric detection of DFC. pH effect shows the participation of an equal number of protons and electrons in the mechanism. The relation between a logarithm of peak current with the logarithm of scan rate indicated adsorption controlled behavior of electrode process. Concentration variations show a good linear response in the range 0.05 µM to 40 µM with the detection limit of 5.25 × 10-8 M. Conclusion: The prepared sensor exhibited good selectivity, sensitivity, and stability for the detection of DFC in the pharmaceutical dosage form and real samples. The developed method could possibly be adopted for pharmacokinetic studies and also in clinical and quality control laboratories where time and economy were important.

Electro-oxidation and Determination of Procainamide at Glassy Carbon Electrode and its Analytical Applications

2016 ◽  
Vol 6 (3) ◽  
pp. 193-204 ◽  
Author(s):  
Manjunath D. Meti ◽  
Jyothi C. Abbar ◽  
Sharanappa T. Nandibewoor ◽  
Shivamurti A. Chimatadar
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Carbon Electrode ◽  
Analytical Applications ◽  
Electro Oxidation

scholarly journals Electrooxidation of Indomethacin at Multiwalled Carbon Nanotubes-Modified GCE and Its Determination in Pharmaceutical Dosage Form and Human Biological Fluids

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Sanjeevaraddi R. Sataraddi ◽  
Shreekant M. Patil ◽  
Atmanand M. Bagoji ◽  
Vijay P. Pattar ◽  
Sharanappa T. Nandibewoor
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Direct Determination ◽  
Reduction Peak ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Multiwalled Carbon ◽  
Pharmaceutical Dosage Form ◽  
Detection Scheme

A simple, rapid, selective, and sensitive electrochemical method for the direct determination of indomethacin was developed. The electrochemical behavior of indomethacin was carried at multiwalled carbon nanotube- (MWCNTs-) modified glassy carbon electrode (GCE). The cyclic voltammetric results indicated that MWCNT-modified glassy carbon electrode remarkably enhanced electrocatalytic activity towards the oxidation of indomethacin in slightly acidic solutions. It led to a considerable improvement of the anodic peak current for indomethacin and could effectively accumulate at this electrode and produce two anodic peaks at 0.720 V and 0.991 V, respectively, and one reduction peak at 0.183 V. The electrocatalytic behavior was further exploited as a sensitive detection scheme for the determination of indomethacin by differential-pulse voltammetry (DPV). Under optimized conditions, the concentration range and detection limit were 0.2 to 6.0 μM and 13.2 nM, respectively. The proposed method was successfully applied to determination of Indomethacine in pharmaceutical samples. The analytical performance of this sensor has been evaluated for detection of analyte in human serum and urine as real samples.

scholarly journals L-ARGININE DETERMINATION IN BIOLOGICALLY ACTIVE ADDITIVE BY VOLTAMMETRY

2020 ◽  
Vol 63 (7) ◽  
pp. 4-9
Author(s):  
Valentina A. Popova ◽  
Maria N. Ponomareva ◽  
Elena I. Korotkova
Keyword(s):  
Differential Pulse Voltammetry ◽  
Dietary Supplement ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Differential Pulse ◽  
Biologically Active ◽  
Carbon Electrode ◽  
Scan Rate ◽  
Pulse Voltammetry

This article reports about the electrochemical determination of L-arginine on a glassy carbon electrode in a dietary supplement using anodic differential pulse voltammetry. The exponential depense of the peak current on the square root of the scan rate (I/v1/2), the shifts of the potential to the negative area and linear correlation between peak potential and logarithm of the scan rate (lg(v)) confirms that electrooxidation of L-arginine is an irreversible process. Moreover, the criteria of Semerano equals 0.4 may indicate the process of electrooxidation without adsorption. The effect of pH, accumulation potential, accumulation time and scan rate was tested on electrochemical behavior of L-arginine. Working conditions for L-arginine determination in model media are following: pH 13; Eacc 0.3 V, tacc 30 s; v = 60 mV s-1. A linear dependence of L-arginine electrooxidation current on its concentration was observed at the 0.9 V in the range between 1.0∙10-4 and 10∙10-4 mol l-1. The detection limit was 1.34∙10-6 mol l-1. A comparative determination of L-arginine in dietary supplement was carried out by the voltammetric method and capillary electrophoresis. Thus, the determination of L-arginine in a dietary supplement on a glassy carbon electrode in NaOH solution (pH 13) was successfully carried out using anodic differential pulse voltammetry. The proposed method does not require sample preparation and allows to quickly determine L-arginine in dietary supplement.

Determination of Cyanuric Acid by Electrochemical Cyclic Voltammetry Method Using CuGeO3 Nanowires as Modified Electrode Materials

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
L. Z. Pei ◽  
Y. K. Xie ◽  
Y. Q. Pei ◽  
Z. Y. Cai ◽  
C. G. Fan
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Method ◽  
Electrode Materials ◽  
Cyanuric Acid ◽  
Cyclic Voltammogram ◽  
Carbon Electrode ◽  
Scan Rate ◽  
Cyclic Voltammetry Method

A simple electrochemical method for the determination of cyanuric acid (CA) has been developed based on a CuGeO3 nanowire modified glassy carbon electrode. The dense CuGeO3 nanowire film can be formed on the surface of the glassy carbon electrode. The roles of scan rate, CA concentration, and electrolytes with different pH values on the electrochemical responses of CA have also been analyzed. The intensities of two anodic peaks vary linearly with the increase of the scan rate from 25 to 200 mVs−1. The intensity of the electrochemical CV peak increases with the increase of the acidity of the electrolytes. The two anodic peak currents are linear with the CA concentration in the range of 0.005–2 mM. The linear correlation coefficient is 0.984 and 0.980 for the cyclic voltammogram peaks (cvp) cvp1 and cvp2, respectively. The detection limit is 4.3 μM and 2.1 μM for cvp1 and cvp2, respectively. The proposed electrochemical method is convenient and effective sensing of CA.

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