scholarly journals Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2021.3

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Richard Aldrich ◽  
K. George Chandy ◽  
Stephan Grissmer ◽  
George A. Gutman ◽  
Leonard K. Kaczmarek ◽  
...  
Keyword(s):  
Potassium Channels ◽  
K Channels ◽  
Voltage Gated ◽  
Herg Channels ◽  
Heteromeric Channels

Calcium- and sodium- activated potassium channels are members of the 6TM family of K channels which comprises the voltage-gated KV subfamilies, including the KCNQ subfamily, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 6 or 7TM) and the Ca2+- and Na+-activated SK subfamily (nomenclature as agreed by the NC-IUPHAR Subcommittee on Calcium- and sodium-activated potassium channels [125]). As for the 2TM family, the pore-forming a subunits form tetramers and heteromeric channels may be formed within subfamilies (e.g. KV1.1 with KV1.2; KCNQ2 with KCNQ3).

scholarly journals Voltage-gated potassium channels (Kv) in GtoPdb v.2021.3

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Bernard Attali ◽  
K. George Chandy ◽  
M. Hunter Giese ◽  
Stephan Grissmer ◽  
George A. Gutman ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Subunit Composition ◽  
Α Subunit ◽  
K Channels ◽  
Voltage Gated ◽  
Functional Channel ◽  
Herg Channels ◽  
Heteromeric Channels

The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.

scholarly journals Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Bernard Attali ◽  
K. George Chandy ◽  
M. Hunter Giese ◽  
Stephan Grissmer ◽  
George A. Gutman ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Subunit Composition ◽  
Α Subunit ◽  
K Channels ◽  
Voltage Gated ◽  
Functional Channel ◽  
Herg Channels ◽  
Heteromeric Channels

The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.

scholarly journals Calcium- and sodium-activated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Richard Aldrich ◽  
K. George Chandy ◽  
Stephan Grissmer ◽  
George A. Gutman ◽  
Leonard K. Kaczmarek ◽  
...  
Keyword(s):  
Potassium Channels ◽  
K Channels ◽  
Voltage Gated ◽  
Herg Channels ◽  
Heteromeric Channels

Calcium- and sodium- activated potassium channels are members of the 6TM family of K channels which comprises the voltage-gated KV subfamilies, including the KCNQ subfamily, the EAG subfamily (which includes herg channels), the Ca2+-activated Slo subfamily (actually with 6 or 7TM) and the Ca2+- and Na+-activated SK subfamily (nomenclature as agreed by the NC-IUPHAR Subcommittee on Calcium- and sodium-activated potassium channels [124]). As for the 2TM family, the pore-forming a subunits form tetramers and heteromeric channels may be formed within subfamilies (e.g. KV1.1 with KV1.2; KCNQ2 with KCNQ3).

Potassium channel block does not affect metabolic responses of brown fat cells

1992 ◽  
Vol 262 (3) ◽  
pp. C678-C681 ◽  
Author(s):  
P. A. Pappone ◽  
M. T. Lucero
Keyword(s):  
Potassium Channels ◽  
Metabolic Response ◽  
Brown Fat ◽  
Neonatal Rat ◽  
K Channel ◽  
Fat Cells ◽  
Adrenergic Stimulation ◽  
K Channels ◽  
Voltage Gated ◽  
Calcium Activated Potassium Channels

Hormonally stimulated brown fat cells are capable of extremely high metabolic rates, making them an excellent system in which to examine the role of plasma membrane ion channels in cell metabolism. We have previously shown that brown fat cell membranes have both voltage-gated and calcium-activated potassium channels (Voltage-gated potassium channels in brown fat cells. J. Gen. Physiol. 93: 451-472, 1989; Membrane responses to norepinephrine in cultured brown fat cells. J. Gen. Physiol. 95: 523-544, 1990). Currents through both the voltage-activated potassium channels, IK,V, and the calcium-activated potassium channels, IK,Ca, can be blocked by the membrane-impermeant K channel blocker tetraethylammonium (TEA). We used microcalorimetric measurements from isolated neonatal rat brown fat cells to assess the role these potassium conductances play in the metabolic response of brown fat cells to adrenergic stimulation. Concentrations of TEA as high as 50 mM, sufficient to block approximately 95% of IK,V and 100% of IK,Ca, had no effect on norepinephrine-stimulated heat production. These results show that neither voltage-gated nor calcium-activated K channels are necessary for a maximal thermogenic response in brown fat cells and suggest that K channels are not involved in maintaining cellular homeostasis during periods of high metabolic activity.

scholarly journals Inwardly rectifying potassium channels (KIR) in GtoPdb v.2021.3

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
John P. Adelman ◽  
David E. Clapham ◽  
Hiroshi Hibino ◽  
Atsushi Inanobe ◽  
Lily Y. Jan ◽  
...  
Keyword(s):  
Potassium Channels ◽  
G Protein ◽  
Inward Rectifier ◽  
K Channel ◽  
Domain Family ◽  
K Channels ◽  
Inwardly Rectifying Potassium Channels ◽  
Inwardly Rectifying ◽  
Α Subunits ◽  
Heteromeric Channels

The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).

scholarly journals Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
John P. Adelman ◽  
David E. Clapham ◽  
Hiroshi Hibino ◽  
Atsushi Inanobe ◽  
Lily Y. Jan ◽  
...  
Keyword(s):  
Potassium Channels ◽  
G Protein ◽  
Inward Rectifier ◽  
K Channel ◽  
Domain Family ◽  
K Channels ◽  
Inwardly Rectifying Potassium Channels ◽  
Inwardly Rectifying ◽  
Α Subunits ◽  
Heteromeric Channels

The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).

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