scholarly journals Inwardly rectifying potassium channels (KIR) in GtoPdb v.2021.3

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
John P. Adelman ◽  
David E. Clapham ◽  
Hiroshi Hibino ◽  
Atsushi Inanobe ◽  
Lily Y. Jan ◽  
...  
Keyword(s):  
Potassium Channels ◽  
G Protein ◽  
Inward Rectifier ◽  
K Channel ◽  
Domain Family ◽  
K Channels ◽  
Inwardly Rectifying Potassium Channels ◽  
Inwardly Rectifying ◽  
Α Subunits ◽  
Heteromeric Channels

The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).

scholarly journals Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
John P. Adelman ◽  
David E. Clapham ◽  
Hiroshi Hibino ◽  
Atsushi Inanobe ◽  
Lily Y. Jan ◽  
...  
Keyword(s):  
Potassium Channels ◽  
G Protein ◽  
Inward Rectifier ◽  
K Channel ◽  
Domain Family ◽  
K Channels ◽  
Inwardly Rectifying Potassium Channels ◽  
Inwardly Rectifying ◽  
Α Subunits ◽  
Heteromeric Channels

The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).

scholarly journals Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels

ACS Omega ◽  
2018 ◽  
Vol 3 (11) ◽  
pp. 14814-14823 ◽  
Author(s):  
Katrin M. Krebs ◽  
Eva M. Pfeil ◽  
Katharina Simon ◽  
Manuel Grundmann ◽  
Felix Häberlein ◽  
...  
Keyword(s):  
Potassium Channels ◽  
G Protein ◽  
High Throughput ◽  
Label Free ◽  
Whole Cell ◽  
Inwardly Rectifying Potassium Channels ◽  
Inwardly Rectifying
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