Correlation of haematological parameters such as haemoglobin, total and differential leucocyte count, platelet count, mean platelet volume, platelet distribution width in relation to glycated haemoglobin in type 2 Diabetes mellitus

ABSTRACT Aims The objective of the study was to determine the mean platelet volume (MPV) and platelet distribution width (PDW) in subjects with type 2 diabetes mellitus (type 2 DM) compared to subjects without type 2 DM and their correlation with fasting blood glucose, glycosylated hemoglobin (HbA1c), and duration of type 2 DM respectively. Materials and methods A prospective analytical case—control study was conducted involving 50 subjects with type 2 DM and 50 subjects without type 2 DM. The mean and standard deviation were estimated for both the groups separately and independent Student's “t”-test was used for evaluating the significant difference. The statistical evaluation was carried out at 95% confidence level. Results Mean MPV and PDW in case group was significantly higher compared to control group (p < 0.005). Fasting blood glucose, HbA1c, and duration of type 2 DM did not significantly alter MPV or PDW. Conclusion The study concludes that MPV and PDW are significantly increased in patients with type 2 DM compared to patients without type 2 DM. Platelet volume indices are an important, simple, and cost-effective tool that should be used and explored extensively, especially in countries, such as India, for predicting the possibility of impending acute vascular events in patients with type 2 DM. Clinical significance This analytical method helps us to use MPV and PDW as early markers of vascular thrombosis. How to cite this article Bhanukumar M, Ramaswamy PKH, Peddi NK, Menon VB. Mean Platelet Volume and Platelet Distribution Width as Markers of Vascular Thrombosis in Type 2 Diabetes Mellitus. J Postgrad Med Edu Res 2016;50(3):127-131.

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The Study of Platelet Parameters- Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) in Type 2 Diabetes Mellitus

Annals of Pathology and Laboratory Medicine ◽

10.21276/apalm.2467 ◽

2019 ◽

Vol 6 (8) ◽

pp. A407-413

Author(s):

Advait Anirudha Joshi ◽

◽

Janice Jaison ◽

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Mean Platelet Volume ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width

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Evaluation of platelet count and mean platelet volume in type 2 diabetes mellitus

Medpusle International Journal of Pathology ◽

10.26611/1051426 ◽

2020 ◽

Vol 14 (2) ◽

pp. 34-37

Author(s):

Priya Bhatt ◽

◽

Jignasa Bhalodia ◽

Mehul Patel ◽

◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Platelet Count ◽

Mean Platelet Volume ◽

Platelet Volume

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Relationship between Altered Platelet Morphological Parameters and Retinopathy in Patients with Type 2 Diabetes Mellitus

Journal of Ophthalmology ◽

10.1155/2016/9213623 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5 ◽

Cited By ~ 5

Author(s):

Tolga Yilmaz ◽

Ahu Yilmaz

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Platelet Count ◽

Large Cell ◽

Distribution Width ◽

Group 4 ◽

Significant Difference ◽

Group 2

Purpose. To investigate whether platelet morphology or function is altered in patients with diabetic retinopathy (DR).Methods. This prospective study enrolled 85 healthy controls (HCs) (group 1) and 262 patients with Type 2 diabetes mellitus (T2DM). Patients were subclassified into three groups according to ocular findings: no DR (group 2;n=88); nonproliferative DR (group 3;n=88), and proliferative DR (group 4;n=86). Mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR), plateletcrit (PCT) values, and platelet count were measured in the studied groups.Results. MPV, PDW, and PLCR levels were significantly altered in groups 2–4 compared with HCs (p<0.05,p<0.05,p<0.05). Compared with group 2, both DR groups had higher MPV and PDW levels, with a significant difference between groups 2 and 4 for both MPV (p=0.036) and PDW (p=0.006). PLCR correlated with retinopathy stage, but no significant difference was found between the DR groups. Platelet count and PCT values were not significantly different between the groups (p>0.05).Conclusion. Our findings suggest an association between mean platelet indices (MPI) (i.e., MPV, PDW, and PLCR) and DR stage. Therefore, MPI could be a beneficial prognostic marker of DR in patients with T2DM.

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Platelet Distribution Width is Associated with Type 2 Diabetes Mellitus and Diabetic Nephropathy and Neuropathy

National Journal of Health Sciences ◽

10.21089/njhs.33.0095 ◽

2018 ◽

Vol 3 (3) ◽

pp. 95-98 ◽

Cited By ~ 2

Author(s):

Burcin M. Atak ◽

◽

Tuba T. Duman ◽

Gulali Aktas ◽

Mehmet Z. Kocak ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Platelet Distribution Width ◽

Distribution Width

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Mean Platelet Volume and Platelet Count in Patients with Type 2 Diabetes Mellitus and Impaired Fasting Glucose

Journal of Nepal Health Research Council ◽

10.33314/jnhrc.v16i41.1502 ◽

2019 ◽

Vol 16 (41) ◽

pp. 392-395

Author(s):

Sushama Bhatta ◽

Samir Singh ◽

Santosh Gautam ◽

Bidur Prasad Osti

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Platelet Count ◽

Impaired Fasting Glucose ◽

Mean Platelet Volume ◽

Fasting Glucose ◽

Vascular Complications ◽

Platelet Volume

Background: Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia and associated with long term macrovascular and microvascular complications. Platelet parameters such as mean platelet volume and platelet count are indicators of thrombotic potential. These parameters have been reported to be increased in diabetic patients, leading to increased risk of vascular complications. The objective of this study was to determine mean platelet volume and platelet count in patients with Type 2 Diabetes mellitus, impaired fasting glucose and non -diabetic controls, and compare mean platelet volume and platelet count between the three groups. Methods: A hospital based cross-sectional observational study was conducted at KIST Medical College Teaching Hospital from February to May 2018. A total of 300 participants were included in the study which were grouped into Group 1,2 and 3 based on fasting blood glucose level as non -diabetic controls, impaired fasting glucose and Type 2 Diabetes mellitus respectively with 100 subjects each. Platelet count and mean platelet volume were compared between the three groups. Analysis of variance with post hoc Tukey test and Pearson correlation coefficient were used for statistical evaluation. Data were expressed as mean ± standard deviation. A p value <0.05 was considered as statistically significant. Results: Mean platelet volume was significantly higher in diabetic and impaired fasting glucose group (7.40 ± 0.77 fl and 6.62 ± 0.58 fl), respectively as compared to non diabetic group (6.06 ± 0.41 fl) (p<0.001). There was no significant difference in the platelet count between the three groups (p=0.869). Significant correlation was seen between rising fasting blood sugar and mean platelet volume (r =0.559; p<0.001), while no correlation existed between platelet count and fasting blood sugar level (r =0.037; p =0.526).Conclusions: Mean platelet volume is increased in patients with type 2 diabetes mellitus and impaired fasting glucose. This is a simple and cost effective test to predict vascular complications in type 2 diabetes mellitus.Keywords: Diabetes mellitus; impaired fasting glucose; mean platelet volume; platelet count.

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