scholarly journals A Rare case of Monoclonal Gammopathy of Renal Significance with Immunotactoid Glomerulopathy Responding to Bortezomib, Dexamethasone and Rituximab

Author(s):  
Chaoyuan Kuang ◽  
Kevin Quann ◽  
Agnes Liman ◽  
Roy Frye ◽  
Nawras Alshoubaki ◽  
...  
Author(s):  
Victoria Campdesuner ◽  
Yeshanew Teklie ◽  
Natalia Lattanzio ◽  
Christian Lorenzo ◽  
Stephen Bell ◽  
...  

2020 ◽  
Vol 7 ◽  
Author(s):  
Giacomo Quattrocchio ◽  
Antonella Barreca ◽  
Antonella Vaccarino ◽  
Giulio Del Vecchio ◽  
Emanuele De Simone ◽  
...  

Monoclonal Gammopathy of Renal Significance (MGRS) is a group of heterogeneous disorders characterized by renal dysfunction secondary to the production of a monoclonal immunoglobulin by a nonmalignant B cell or plasma cell clone. We report the clinical and histological outcomes of two patients with biopsy-proven MGRS: one patient showed membranoproliferative glomerulonephritis with monoclonal k-light chain and C3 deposits, the second patient showed immunotactoid glomerulopathy. Both patients were treated with a 9-month chemotherapy protocol including bortezomib, cyclophosphamide, and dexamethasone. Renal biospy was repeated after 1 year. The estimated glomerular filtration rate (eGFR) increased from 22.5 (baseline) to 40 ml/min per 1.73 m2 after 12 months, then to 51.5 ml/min per 1.73 m2 after 24 months; proteinuria decreased from 4.85 (baseline) to 0.17 g/day after 12 months, then to 0.14 g/day after 24 months. Repeat renal biopsies showed a dramatic improvement of the glomerular proliferative lesions and near complete disappearance of the immune deposits. A bortezomib-based treatment proved very effective and was well-tolerated in the two patients presenting with clinically and histologically aggressive MGRS.


Author(s):  
Manish Rijhwani ◽  
Divya Yadav ◽  
Manisha Nijhawan ◽  
Arvind Verma

<p class="abstract">Erythema elevatum diutinum (EED) is a rare form of leukocytoclastic vasculitis with an unclear pathogenesis. Almost 250 cases of EED have been reported in the literature, associated with several diseases and presented with various clinical features. Term 'diutinum' means chronic, describes one of the main characteristic features. The duration is very long, varying between one to more than 39 years. We report a rare presentation of EED in a 58-years-old man who presented with extensive and symmetrical, persistent, erythematous to violaceous   plaques over trunk and limbs and popular-nodular lesions present over pinna and dorsum of hands with burning sensation and itching over few lesions, in association with IgA monoclonal gammopathy.</p>


2001 ◽  
Vol 38 (2) ◽  
pp. 395-399 ◽  
Author(s):  
Nael Da[apos ]as ◽  
Yosef Kleinman ◽  
Aaron Polliack ◽  
Gail Amir ◽  
Zvi Ne[apos ]eman ◽  
...  

2020 ◽  
Vol 8 (10) ◽  
pp. 1984-1987
Author(s):  
Chaoyuan Kuang ◽  
Kevin Quann ◽  
Agnes K. Liman ◽  
Roy Frye ◽  
Nawras Alshoubaki ◽  
...  

2015 ◽  
Vol 30 (5) ◽  
pp. 510-512 ◽  
Author(s):  
Brian Castillo ◽  
Brian N. Chang ◽  
Amer Wahed ◽  
Ashok Tholpady

The Lancet ◽  
2021 ◽  
Vol 397 (10289) ◽  
pp. 2081
Author(s):  
Satoshi Inotani ◽  
Taro Horino ◽  
Masayuki Ishihara ◽  
Osamu Ichii ◽  
Akinori Matsumori

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