The electrochemical behavior and electrochemical determination of
carbamazepine (CBZ) at hydrophobic ionic liquid 1-Benzyl-3-Methylimidazole
hexafluorophosphate ([BnMIM]PF6) modified carbon paste electrode
([BnMIM]PF6/CPE) in the presence of sodium dodecyl sulfate (SDS) were
investigated. A well-defined and sensitive oxidation peak was observed at
[BnMIM]PF6/CPE in the presence of SDS and 0.10 M phosphate buffer solution
(pH 6.80). The oxidation peak current of CBZ increased significantly at
[BnMIM]PF6/CPE in the presence of SDS compared with that in the absence of
SDS at carbon paste electrode. It suggested that both SDS and [BnMIM]PF6/CPE
show an obvious enhancing effect on the electrochemical oxidation of CBZ. The
electrochemical kinetic parameters for CBZ at [BnMIM]PF6/CPE in aqueous SDS
solutions were also determined by Chronocoulometry and Chronoamperometry.
Finally, the experimental conditions were optimized, and a new
electrochemical method of determination for CBZ had been established. The
oxidation peak current was linearly dependent on CBZ concentration in the
range of 7.0 ?M to 0.7 mM with a detection limit of 0.98 ?M (signal to noice
ratio, S/N = 3). The relative standard deviation for six determinations of
0.10 mM CBZ was between 1.40 and 2.13%. The proposed method was applied in
the determination of CBZ in commercial tablet samples.
Electrochemical behavior of labetalol at an ionic liquid modified carbon paste electrode and its electrochemical determination
