Uric Acid
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2021 ◽  
Guqiao Nie ◽  
Jing Jing Wan ◽  
Lei Jiang ◽  
Shu Kai Hou ◽  
Wen Peng

Abstract Background:The prevalence of metabolic syndrome in the elderly is gradually increasing,which accounts for the largest burden of non-communicable diseases worldwide and has direct effects on health. Research on the relationship between uric acid and metabolic syndrome in the elderly is relatively lacking. The purpose of this study is to explore the diagnostic value of uric acid levels for metabolic syndrome, compared to other components of metabolic syndrome.Materials and methods:We collected the physical examination data of 1,267 elderly people in the community in Wuhan, and used SPSS IBM 22.0 for data analysis. Perform correlation analysis, logistic regression analysis and draw ROC curve. Results:The prevalence of hyperuricemia was 28.1%, and metabolic syndrome was 18.6%; the uric acid level of the non-metabolic syndrome group was lower than that of the metabolic syndrome group (337.31 vs 381.91 µmol/ L; P<0.05); Pearson analysis revealed uric acid levels are correlated with blood pressure, BMI, triglyceride, high-density lipoprotein cholesterol. Logistic regression analysis results suggest that uric acid is a risk factor for metabolic syndrome. Metabolic syndrome components TG and HDL levels are also related to uric acid levels. The result is described as OR value and 95% CI (OR 1.003 [1.001, 1.005]). By drawing the ROC curve, we found that the area under the curve for uric acid to diagnose metabolic syndrome is 0.64 (sensitivity: 79.3%, specificity: 45.1%), which is similar to other components of metabolic syndrome. Conclusion:We confirmed the correlation between uric acid levels and metabolic syndrome in the elderly Chinese population.

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260957
Edit Szabó ◽  
Anna Kulin ◽  
Orsolya Mózner ◽  
László Korányi ◽  
Botond Literáti-Nagy ◽  

Type 2 diabetes mellitus (T2DM) is a complex metabolic disease and variations in multispecific membrane transporter functions may affect T2DM development, complications or treatment. In this work we have analyzed the potential effects of a major polymorphism, the Q141K variant of the ABCG2 transporter in T2DM. The ABCG2 protein is a multispecific xeno- and endobiotic transporter, affecting drug metabolism and playing a key role in uric acid extrusion. The ABCG2-Q141K variant, with reduced expression level and function, is present in 15–35% of individuals, depending on the genetic background of the population, and has been shown to significantly affect gout development. Several other diseases, including hypertension, chronic renal failure, and T2DM have also been reported to be associated with high serum uric acid levels, suggesting that ABCG2 may also play a role in these conditions. In this work we have compared relatively small cohorts (n = 203) of T2DM patients (n = 99) and healthy (n = 104) individuals regarding the major laboratory indicators of T2DM and determined the presence of the SNP rs2231142 (C421A), resulting the ABCG2-Q141K protein variant. We found significantly higher blood glucose and HbA1c levels in the T2DM patients carrying the ABCG2-Q141K variant. These findings may emphasize the potential metabolic role of ABCG2 in T2DM and indicate that further research should explore how prevention and treatment of this disease may be affected by the frequent polymorphism of ABCG2.

2021 ◽  
Vol 4 (6) ◽  
pp. 1554-1560
Triyoso Triyoso ◽  
Muhammad Agustianda ◽  
Wahid Tri Wahyudi

ABSTRAK Gout merupakan penyakit metabolik yang disebabkan oleh kelebihan kadar senyawa urat didalam tubuh, baik karena produksi berlebih, eliminasi yang kurang, atau peningkatan asupan purin. Salah satu terapi nonfarmakologik yang telah terbukti mampu mengatasi berbagai permasalahan kesehatan adalah akupresur. Akupresur yaitu tindakan pemberian tekanan ke titik khusus pada tubuh untuk mengurangi peningkatan kadar asam urat, menghasilkan relaksasi, dan mencegah atau mengurangi rasa mual. Tujuan pelaksanaan pengabdian kepada masyarakat ini untuk mendapatkan pengalaman dan kompetensi lebih dalam pemberian asuhan keperawatan komprehensif pemberian terapi Akupresure terhadap penurunan kadar asam urat. Adapun kegiatan yang dilakukan berupa penyuluhan menggunakan leaflet dan demonstrasi terapi akupresure. Terdapat penurunan kadar asam urat setelah dilakukan terapi akupresure pada penderita asam urat. Terapi akupresure sangat efektif dalam menurunkan kadar asam urat.                                                                                                Kata Kunci: Akupresure, Asam urat, Kadar asam urat  ABSTRACT Gout is a metabolic disease caused by excess levels of urate compounds in the body, either due to overproduction, lack of elimination, or increased intake of purines. One non-pharmacologic therapy that has been proven able to overcome various health problems is acupressure. Acupressure is the act of applying pressure to a special point on the body to reduce the increase in uric acid levels, produce relaxation, and prevent or reduce nausea. The purpose of the study was to gain more experience and competence in the provision of comprehensive nursing care in the provision of acupressure therapy for decreasing uric acid levels. The activities carried out in the form of counseling using leaflets and demonstrations of acupressure therapy. There was a decrease in uric acid levels after doing acupressure therapy in gout sufferers. Thus, acupressure therapy was very effective in reduces uric acid levels. Keywords: Acupressure, Gout, Uric Acid Levels 

2021 ◽  
Vol 8 ◽  
Hae Kyung Kim ◽  
Minyoung Lee ◽  
Yong-ho Lee ◽  
Byung-Wan Lee ◽  
Bong-Soo Cha ◽  

Background: Cardiovascular disease (CVD) is associated with morbidity and mortality in patients with type 2 diabetes mellitus (T2D). However, the role of serum uric acid as a risk factor for developing cardiovascular disease is controversial. This study investigated whether uric acid variability was associated with new-onset symptomatic CVD in patients with T2D, requiring percutaneous coronary intervention.Methods: A total of 1,071 patients were enrolled in this retrospective cross-sectional study after propensity score matching. Patients with T2D and new-onset symptomatic CVD who received percutaneous coronary intervention for the first time, and with at least three consecutive 6-monthly measurements of serum uric acid were recruited from Severance Hospital between January 2015 and December 2019. Uric acid variability was measured by average successive variability (ASV) and analyzed to evaluate a possible correlation with the risk of developing CVD.Results: The patients were divided into quartiles based on the uric acid variability. Patients in the highest quartile were older and presented lower renal function and a higher mortality from CVD. There was a linear association between a high uric acid variability and the development of CVD. Compared to the lowest quartile, patients in the higher quartiles had a higher risk of CVD [quartile 3: adjusted odds ratio (aOR) = 1.76; 95% confidence interval (CI), 1.20–2.82; P = 0.019; quartile 4 aOR = 2.89; 95% CI, 1.74–4.80; P &lt; 0.001].Conclusion: High uric acid variability is independently associated with an increased risk of new-onset symptomatic CVD requiring percutaneous coronary intervention in patients with T2D. Thus, maintaining serum uric acid in a narrow range by prescribing effective medications is essential to prevent new-onset CVD in patients with T2D. Nonetheless, the potential use of uric acid variability as a predictive marker of CVD in patients with T2D needs further validation.

2021 ◽  
Wentao Zhu ◽  
An Liang ◽  
Pei Shi ◽  
Song Yuan ◽  
Ying Zhu ◽  

Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is commonly occurred in the non-obese individuals. The serum uric acid (UA) to high-density lipoprotein cholesterol (HDL-c) ratio (UHR) is considered as a predictive factor of NAFLD. However, it is still difficult to confirm the correlation in lean Chinese people with normal blood lipid levels. It is aimed to analyze the correlation of UHR with NAFLD among lean Chinese population without dyslipidemia and compared UHR with other predictors in this study.Methods: 9838 lean people without NAFLD were included in a retrospective cohort study. NAFLD was diagnosed by liver ultrasound.Results: A total of 9,838 lean patients with normal blood lipid levels were included in the final study. During the five-year follow-up period, the overall prevalence of NAFLD was 8.7%. across the quintile 1, 2, 3, 4 and 5 of UHR, the prevalence of NAFLD among lean patients was increased from 2.4%, 5%, 7.9%, 10.3% to 17.8%. After adjustment for age, markers of liver and kidney function, gender and metabolic indicators, multivariate cox proportional hazard regression analysis demonstrated that the hazard ratio(HR) was 1.99(1.43-2.73) in highest UHR (quintile 5) compared with lowest UHR(quintile 1). The area under the curve(AUC) of UHR (0.690) was higher than in UA (0.666) and HDL-c (0.636), which showed that the predictive ability of the UHR to new-onset NAFLD was better than serum uric acid and HDL-c. Even within the normal range of UA and HDL-c levels, UHR was independently associated with NAFLD, and HR (95% confidence interva, 95%CI) for NAFLD in Quintile 5 of UHR was 6.74(4.32-10.53). Compared with other significant predictors, the AUC value of UHR(0.67) was similar to that of low-density lipoprotein cholesterol(LDL-c)/HDL-c ratio(0.68), non-high-density lipoprotein cholesterol (NHDL-c)/HDL-c ratio(0.68) and alanine aminotransferase (ALT)/ aspartate aminotransferase (AST) ratio(0.7), and superior to that of LDL-c (0.63), remnant cholesterol (RC,0.59), albumin(ALB)/alkaline phosphatase(ALP) ratio(0.61). The sensitivity of UHR (70.5%) was the highest among all indicators. In the subgroup of ALT, the AUC of UHR was 0.70, which was the highest among all predictors in subjects with ALT< 40. For subjects with elevated ALT levels (ALT > 40 U/L), there was no statistical significance among RC (P=0.441), ALB/ALP (P=0.419) and ALT/AST(P=0.159). In contrast, UHR's performance in predicting NAFLD was meaningful and reliable (AUC=0.61, p<0.001).Conclusions: UHR serve as an inexpensive and reliable predictor of NAFLD in lean Chinese people with normal blood lipid levels. It can be used to identify people at high risk of NAFLD.

2021 ◽  
pp. 164-169
V. V. Tsurko ◽  
M. A. Gromova

Introduction. To date, there is no consensus regarding the gender characteristics of the course of gout. There is little data on the possible difference between men and women in response to uric acid-lowering therapy.Aim. To compare the clinical characteristics of the course of gout and evaluate the differences in response to urate-lowering therapy (ULT) with allopurinol and febuxostat in men and women.Material and methods. The retrospective cohort study included 279 men and 83 women diagnosed with gout (ACR/EULAR, 2015). The comparative analysis of the clinical characteristics of gout, as well as responses to the intake of xanthioxidase (XO) inhibitors in representatives of different sexes, was carried out. We compared the gender characteristics of obtaining a positive response to ULT, defined as achieving a target serum uric acid (sUA) level of < 360 μmol / l within 6 months of treatment, while taking allopurinol and febuxostat.Results. By the age at which the onset of gout took place, women were older than men, the duration of the disease in them was shorter. Men showed a shorter duration of the first attack of arthritis. Chronic arthritis was diagnosed in 56% of men and 35% of women (p < 0.05). The process involved the joints of both the lower and upper extremities. However, more often the joints of the lower extremities were affected in men, and in the upper extremities in women. Tophus were detected in 35% of patients, of whom 30.3% were men, 4.7% were women (p < 0.05). Allopurinol was prescribed to 216 men and 54 women, and febuxostat was prescribed to 63 men and 29 women. After six months, the proportion of women who achieved the target sUA was 57.5% and 65.8%, the proportion of men – 60.4% and 76.2% for allopurinol and febuxostat, respectively.Conclusion. The clinical manifestations of gout in men and women differ. Due to the pronounced increase in the level of uric acid, men develop more severe joint damage due to the tendency to chronicity. However, the study did not reveal gender differences in the response to XO inhibitors, which indicates that there is no need to choose therapy depending on the patient’s gender.

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