scholarly journals Isolated metastasis of the granulosa cell tumor of the ovary in the small intestine mesentery 19 years after salpingo-oophorectomy

2006 ◽  
Vol 134 (11-12) ◽  
pp. 546-549
Author(s):  
Radoje Colovic ◽  
Nikica Grubor ◽  
Marjan Micev ◽  
Natasa Colovic ◽  
Vladimir Radak
Keyword(s):  
Granulosa Cell ◽  
Stromal Cells ◽  
Mesenteric Artery ◽  
Inferior Mesenteric Artery ◽  
Granulosa Cell Tumor ◽  
Postoperative Recovery ◽  
Cell Tumor ◽  
Fat Tissue ◽  
Stromal Tumors ◽  
First Case

Introduction: Granulosa cell tumor is uncommon malignant tumor which belongs to the sexual cord-stromal tumors of the ovary. It arises from the specialized stromal cells of the ovary. These tumors are unilateral in 95%. Over 90% of patients survive more than 10 years after surgery, but the recurrence may appear even 25 years after surgery. CASE REPORT The authors present a 54-year old woman who was admitted for abdominal pain and ultrasonography revealed tumor in the abdomen. During the surgery, a spheric, well circumscribed tumor of the mesentery, close to the forth portion of duodenum, was excised. Histological and immunohistochemical examinations verified that it was the metastasis of the granulosa cell tumor of the ovary that had been removed 19 years ago when salpingo-oophorectomy had been performed. Postoperative recovery was uneventful. Twenty six months later, the tumor 4 cm in diameter recurred, and was localized to the left of duodenum, close to the inferior mesenteric artery, which was perfectly ideally, together with fat tissue and surrounding lymph nodes. She has remained symptom free so far. Conclusion: To the best of our knowledge, this is the first case of the isolated metastasis of the granulosa cell tumor in the mesentery, that appeared 19 years after original surgery.

scholarly journals Adult Testicular Granulosa Cell Tumor: A Review of the Literature for Clinicopathologic Predictors of Malignancy

2011 ◽  
Vol 135 (1) ◽  
pp. 143-146 ◽  
Author(s):  
Joshua Anspach Hanson ◽  
Abiy B. Ambaye
Keyword(s):  
Granulosa Cell ◽  
Case Reports ◽  
Granulosa Cell Tumor ◽  
Malignant Potential ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Stromal Tumors ◽  
Granulosa Cell Tumors ◽  
Pathologic Features ◽  
Sex Cord Stromal Tumors

Abstract Adult testicular granulosa cell tumors are rare sex cord–stromal tumors of which only 28 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive course because the proportion of malignant cases is higher. To date, there are no clinical or pathologic features that definitively predict malignancy. We reviewed all prior case reports for features that may predict their malignant potential. Tumor size greater than 5.0 cm is the only feature statistically associated with malignancy. Mitotic count, tumor necrosis, patient age, and the presence of gynecomastia do not, at present, predict benign versus malignant behavior.

scholarly journals First Case of a Primary Lung Granulosa Cell Tumor With a Mutation in the Forkhead Box L2 Gene

2019 ◽  
Vol 14 (5) ◽  
pp. e100-e102
Author(s):  
Aya Izuwa ◽  
Gouji Toyokawa ◽  
Fumihiro Shoji ◽  
Koji Yamazaki ◽  
Seiya Momosaki ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Forkhead Box ◽  
First Case

First Case of Juvenile Granulosa Cell Tumor in an Adult With Ollier Disease

2009 ◽  
Vol 28 (5) ◽  
pp. 464-467 ◽  
Author(s):  
Lieke Rietveld ◽  
Theodoor E. Nieboer ◽  
Kirsten B. Kluivers ◽  
Hendrik W. B. Schreuder ◽  
Johannes Bulten ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
First Case ◽  
Juvenile Granulosa Cell Tumor ◽  
Ollier Disease

Sex Cord Tumor With Annular Tubules–Like Histologic Pattern in Adult Granulosa Cell Tumor: Case Report of a Hitherto Unreported Morphologic Variant

2020 ◽  
pp. 106689692095362
Author(s):  
Ruby J. Chang ◽  
Jacquelyn Reuther ◽  
Ilavarasi Gandhi ◽  
Angshumoy Roy ◽  
Shilpa Jain ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Molecular Testing ◽  
Molecular Signatures ◽  
Unique Case ◽  
Stromal Tumors ◽  
Mutation Profile ◽  
Histologic Pattern ◽  
Sex Cord Stromal Tumors

Adult granulosa cell tumor (AGCT) and sex cord tumor with annular tubules (SCTAT) are distinct sex cord stromal tumors with different molecular signatures. We present a unique case of an incidental ovarian tumor with mixed AGCT and SCTAT morphologic patterns. Due to the unusual co-occurrence, molecular testing was separately performed on both components. Despite minimal overlap in morphology, both the SCTAT and AGCT components were found to have an identical mutation profile, including the prototypical FOXL2 p.C134W mutation characteristic of AGCT. We thus present the first report of AGCT with SCTAT-like pattern.

scholarly journals Ovarian Sex Cord–Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD

2018 ◽  
Vol 142 (12) ◽  
pp. 1459-1484 ◽  
Author(s):  
Robert H. Young
Keyword(s):  
Granulosa Cell ◽  
Wide Spectrum ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Stromal Tumor ◽  
Entire Family ◽  
Stromal Tumors ◽  
Juvenile Granulosa Cell Tumor ◽  
Sclerosing Stromal Tumor ◽  
Sex Cord Stromal Tumors

Context.— This year being the 60th anniversary of the publication of the excellent book Endocrine Pathology of the Ovary by John McLean Morris, MD, and Robert E. Scully, MD, the writer reflects on that work and in particular the remarkable contributions of its second author to our knowledge in this area. Objective.— To review ovarian sex cord–stromal tumors. Data Sources.— Literature and personal experience. Conclusions.— The essay begins with remarks on the oftentimes straightforward stromal tumors of the ovary because the commonest of them, the fibroma, dominates from the viewpoint of case numbers. Then, the sclerosing stromal tumor and the peculiar so-called luteinized thecomas of the type associated with sclerosing peritonitis are discussed in greater detail and their wide spectrum is illustrated. Brief mention is made of 2 rare neoplasms: the ovarian myxoma and signet-ring stromal tumor. Discussion then turns to the more recently recognized intriguing tumor tentatively designated microcystic stromal tumor and the commonest malignant tumor in this entire family, the so-called adult granulosa cell tumor, which despite its name may occasionally be seen in young individuals. The second variant of granulosa cell tumor—that which usually, but not always, occurs in the young—the so-called juvenile granulosa cell tumor, is then discussed. In the section of Sertoli-Leydig cell tumors, particular attention is focused on unusual tumors with heterologous elements and the remarkable so-called retiform tumors, which have a predilection for the young, often have distinctive gross features, and exhibit slitlike spaces and papillae. The essay concludes with consideration of the sex cord tumor with annular tubules.

scholarly journals Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis

2009 ◽  
Vol 30 (5) ◽  
pp. 869-878 ◽  
Author(s):  
A. Boyer ◽  
M. Paquet ◽  
M.-N. Lague ◽  
L. Hermo ◽  
D. Boerboom
Keyword(s):  
Granulosa Cell ◽  
Stromal Cells ◽  
Granulosa Cell Tumor ◽  
Akt Signaling ◽  
Cell Tumor

scholarly journals A rare case of virilizing adult granulosa cell tumor

1970 ◽  
Vol 39 (136) ◽  
pp. 351-353
Author(s):  
Kaveeta Dawaka ◽  
A Gupta ◽  
S Joshi ◽  
S Bajpai ◽  
H S Basi
Keyword(s):  
Granulosa Cell ◽  
Ovarian Tumor ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Stromal Tumors ◽  
Cystic Tumors ◽  
History Of ◽  
Disproportionate Number ◽  
Sex Cord Stromal Tumors

A twenty eight year old lady, married for two years with no issue, presented at WesternRegional Hospital Pokhara on 8th July, 1999 with a history of amenorrhea for 1½years, lump abdomen 1 year, hoarseness of voice for 1 year and signs of hirsutism forthe same duration. She was taken up for laparotomy wherein a left ovariectomy withsalpingectomy was done and a large cystic ovarian tumor was removed. Post operativeperiod was uneventful and she was advised follow up. The histopathological diagnosiswas Adult Granulosa Cell Tumor. What made this case interesting is that mostGranulosa Cell Tumors (about 3/4th) are estrogenic or feminizing, but rare examples,including a disproportionate number of large thin walled cystic tumors are androgenic.This was one of those rare virilizing tumors with classical features of infertility,amenorrhea, hoarseness of voice, clitiromegaly, and breast atrophy, but we could notestimate testosterone levels due to lack of facilities available.Key Words: Granulosa Cell Tumor, Virilizing Ovarian Tumors, Sex Cord stromal tumors.

Postmenopausal hirsutism and hyperandrogenemia due to granulosa cell tumor of the ovary

2013 ◽  
Author(s):  
Cigdem Bahadir ◽  
Aysegul Atmaca ◽  
Hulusi Atmaca ◽  
Ramis Colak
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor
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