scholarly journals A rare case of virilizing adult granulosa cell tumor

1970 ◽  
Vol 39 (136) ◽  
pp. 351-353
Author(s):  
Kaveeta Dawaka ◽  
A Gupta ◽  
S Joshi ◽  
S Bajpai ◽  
H S Basi
Keyword(s):  
Granulosa Cell ◽  
Ovarian Tumor ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Stromal Tumors ◽  
Cystic Tumors ◽  
History Of ◽  
Disproportionate Number ◽  
Sex Cord Stromal Tumors

A twenty eight year old lady, married for two years with no issue, presented at WesternRegional Hospital Pokhara on 8th July, 1999 with a history of amenorrhea for 1½years, lump abdomen 1 year, hoarseness of voice for 1 year and signs of hirsutism forthe same duration. She was taken up for laparotomy wherein a left ovariectomy withsalpingectomy was done and a large cystic ovarian tumor was removed. Post operativeperiod was uneventful and she was advised follow up. The histopathological diagnosiswas Adult Granulosa Cell Tumor. What made this case interesting is that mostGranulosa Cell Tumors (about 3/4th) are estrogenic or feminizing, but rare examples,including a disproportionate number of large thin walled cystic tumors are androgenic.This was one of those rare virilizing tumors with classical features of infertility,amenorrhea, hoarseness of voice, clitiromegaly, and breast atrophy, but we could notestimate testosterone levels due to lack of facilities available.Key Words: Granulosa Cell Tumor, Virilizing Ovarian Tumors, Sex Cord stromal tumors.

scholarly journals Adult Testicular Granulosa Cell Tumor: A Review of the Literature for Clinicopathologic Predictors of Malignancy

2011 ◽  
Vol 135 (1) ◽  
pp. 143-146 ◽  
Author(s):  
Joshua Anspach Hanson ◽  
Abiy B. Ambaye
Keyword(s):  
Granulosa Cell ◽  
Case Reports ◽  
Granulosa Cell Tumor ◽  
Malignant Potential ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Stromal Tumors ◽  
Granulosa Cell Tumors ◽  
Pathologic Features ◽  
Sex Cord Stromal Tumors

Abstract Adult testicular granulosa cell tumors are rare sex cord–stromal tumors of which only 28 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive course because the proportion of malignant cases is higher. To date, there are no clinical or pathologic features that definitively predict malignancy. We reviewed all prior case reports for features that may predict their malignant potential. Tumor size greater than 5.0 cm is the only feature statistically associated with malignancy. Mitotic count, tumor necrosis, patient age, and the presence of gynecomastia do not, at present, predict benign versus malignant behavior.

Sex Cord Tumor With Annular Tubules–Like Histologic Pattern in Adult Granulosa Cell Tumor: Case Report of a Hitherto Unreported Morphologic Variant

2020 ◽  
pp. 106689692095362
Author(s):  
Ruby J. Chang ◽  
Jacquelyn Reuther ◽  
Ilavarasi Gandhi ◽  
Angshumoy Roy ◽  
Shilpa Jain ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Molecular Testing ◽  
Molecular Signatures ◽  
Unique Case ◽  
Stromal Tumors ◽  
Mutation Profile ◽  
Histologic Pattern ◽  
Sex Cord Stromal Tumors

Adult granulosa cell tumor (AGCT) and sex cord tumor with annular tubules (SCTAT) are distinct sex cord stromal tumors with different molecular signatures. We present a unique case of an incidental ovarian tumor with mixed AGCT and SCTAT morphologic patterns. Due to the unusual co-occurrence, molecular testing was separately performed on both components. Despite minimal overlap in morphology, both the SCTAT and AGCT components were found to have an identical mutation profile, including the prototypical FOXL2 p.C134W mutation characteristic of AGCT. We thus present the first report of AGCT with SCTAT-like pattern.

scholarly journals Ovarian Sex Cord–Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD

2018 ◽  
Vol 142 (12) ◽  
pp. 1459-1484 ◽  
Author(s):  
Robert H. Young
Keyword(s):  
Granulosa Cell ◽  
Wide Spectrum ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Stromal Tumor ◽  
Entire Family ◽  
Stromal Tumors ◽  
Juvenile Granulosa Cell Tumor ◽  
Sclerosing Stromal Tumor ◽  
Sex Cord Stromal Tumors

Context.— This year being the 60th anniversary of the publication of the excellent book Endocrine Pathology of the Ovary by John McLean Morris, MD, and Robert E. Scully, MD, the writer reflects on that work and in particular the remarkable contributions of its second author to our knowledge in this area. Objective.— To review ovarian sex cord–stromal tumors. Data Sources.— Literature and personal experience. Conclusions.— The essay begins with remarks on the oftentimes straightforward stromal tumors of the ovary because the commonest of them, the fibroma, dominates from the viewpoint of case numbers. Then, the sclerosing stromal tumor and the peculiar so-called luteinized thecomas of the type associated with sclerosing peritonitis are discussed in greater detail and their wide spectrum is illustrated. Brief mention is made of 2 rare neoplasms: the ovarian myxoma and signet-ring stromal tumor. Discussion then turns to the more recently recognized intriguing tumor tentatively designated microcystic stromal tumor and the commonest malignant tumor in this entire family, the so-called adult granulosa cell tumor, which despite its name may occasionally be seen in young individuals. The second variant of granulosa cell tumor—that which usually, but not always, occurs in the young—the so-called juvenile granulosa cell tumor, is then discussed. In the section of Sertoli-Leydig cell tumors, particular attention is focused on unusual tumors with heterologous elements and the remarkable so-called retiform tumors, which have a predilection for the young, often have distinctive gross features, and exhibit slitlike spaces and papillae. The essay concludes with consideration of the sex cord tumor with annular tubules.

Adult Granulosa Cell Tumor of the Ovary: A Clinico Pathologic Study of 35 Cases

1998 ◽  
Vol 84 (1) ◽  
pp. 60-64 ◽  
Author(s):  
Rosanna Fontanelli ◽  
Bernardina Stefanon ◽  
Francesco Raspagliesi ◽  
Rado Kenda ◽  
Gorana Tomasic ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Disease Free Survival ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Progression Rate ◽  
Free Survival ◽  
Tumor Involvement ◽  
Disease Free Survival Rate ◽  
Disease Free

Aims and background Adult granulosa cell tumor has a low malignant potential but requires an extensive follow-up of more than 5 years to accurately assess tumor activity. The aim of the present study was to evaluate the clinical characteristics, the treatment and the outcome of this rare ovarian tumor. Study design A retrospective review of 35 cases treated at primary onset of disease during a 23-year period from 1971 to 1993. Results The disease-free survival rate for stages IA-B-C at 5 and 10 years was 90% and 84%, respectively; for stages III-IV the 5-year freedom from progression rate was 16%. Conclusions The most important prognostic factor appears to be the extent of tumor involvement outside of the ovary.

scholarly journals Granulosa Cell Tumor Of The Ovary – An Incidental Finding During Caesarean Section – A Rare Case Report

2015 ◽  
Vol 12 (1) ◽  
pp. 60-63
Author(s):  
J Roy ◽  
AS Babu
Keyword(s):  
Caesarean Section ◽  
Granulosa Cell ◽  
Incidental Finding ◽  
Treatment Plan ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Ovarian Teratoma ◽  
Borderline Tumor ◽  
Rare Case Report

Approximately one-fourth of the ovarian neoplasms and cysts are diagnosed incidentally during caesarean section. The possibility of borderline tumor or cancer should be considered although existence of ovarian malignancy in pregnancy is rare. We report a case of a rare solid malignant tumor of the ovary incidentally found during caesarean section. Intraoperatively, it was thought to be a variant of the common ovarian teratoma. Ovariectomy was done but histopathology revealed it to be granulosa cell tumor. The diagnosis changed the prognosis and future treatment plan drastically. Equipped with this knowledge physicians can be made aware of the existence of this little-known ovarian neoplasm along with its rare association with pregnancy. Also one can better manage, counsel and follow-up the patients after delivery, given the knowledge of the tumours’ inevitable malignant potential and its high incidence of recurrence.Kathmandu University Medical Journal Vol.12(1) 2014: 60-63

scholarly journals Granulosa cell tumor complicated by torsion, rupture and hemoperitoneum

2021 ◽  
Vol 10 (6) ◽  
pp. 2489
Author(s):  
Kripa Sherchan
Keyword(s):  
Postmenopausal Woman ◽  
Granulosa Cell ◽  
Ovarian Tumor ◽  
Vaginal Bleeding ◽  
Granulosa Cell Tumor ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Cell Tumor ◽  
Primary Therapy ◽  
Malignant Ovarian Tumor

Granulosa cell tumor, a sex cord stromal estrogen secreting tumor presents with vaginal bleeding and is seen in all ages. It accounts for <5% of all ovarian neoplasm. We reported a rare case of granulosa cell tumor in a postmenopausal woman undergoing staging laparotomy with total abdominal hysterectomy and bilateral salpingo-oopherectomy for malignant ovarian tumor, which was complicated by torsion, rupture and hemorrhagic ascitis. Any ovarian tumor with vaginal bleeding should arouse suspicion of granulosa cell tumor in the background of postmenopausal woman. For most patients, surgery alone is sufficient primary therapy, Radiation and chemotherapy are reserved for the treatment of recurrent or metastatic disease.

scholarly journals Extraovarian Granulosa Cell Tumor of Mesentery: A Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Manjiri R. Naniwadekar ◽  
N. J. Patil
Keyword(s):  
Granulosa Cell ◽  
Histopathological Examination ◽  
Previous History ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Genital Ridge ◽  
Adult Type ◽  
Mesenteric Mass ◽  
History Of ◽  
Ovary Tumor

Extraovarian granulosa cell tumor (GCT) is a very uncommon tumor, assumed to arise from the ectopic gonadal tissue along the embryonal route of the genital ridge. A 54 years old female patient presented with a mass and acute pain in abdomen. Exploratory laparatomy revealed hemoperitoneum with a large mesenteric mass measuring 13 × 12 cm in size, showing extensive areas of haemorrhages. Histopathological examination of the excised mass showed features of adult-type GCT. As the patient had a history of hysterectomy with bilateral salpingo-oophorectomy 10 years ago for ‘‘leiomyoma’’ with no evidence of GCT of the ovary in the histopathology report, a diagnosis of extraovarian GCT was made. A diagnosis of extraovarian GCT should be carried out after excluding any previous history of GCT of the ovary. Tumor rupture with haemoperitoneum is a well-known complication of GCT. Extraovarian GCT is a rare tumor with only 10 cases reported in literature. The case is presented for its rarity.

Long natural history of recurrent granulosa cell tumor of the ovary 23 years after initial diagnosis: a case report and review of the literature

2005 ◽  
Vol 96 (1) ◽  
pp. 235-240 ◽  
Author(s):  
Katherine D. Crew ◽  
Michael H. Cohen ◽  
Daniel H. Smith ◽  
Amy D. Tiersten ◽  
Nikki M. Feirt ◽  
...  
Keyword(s):  
Case Report ◽  
Natural History ◽  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Initial Diagnosis ◽  
Review Of The Literature ◽  
History Of

Mixed Ovarian Tumor Composed of Brenner Tumor and Adult-Type Granulosa Cell Tumor: A Case Report of a Very Rare Mixed Ovarian Tumor and a Review of the Literature

2017 ◽  
Vol 26 (4) ◽  
pp. 382-387
Author(s):  
Judit Tamás ◽  
Ildikó Vereczkey ◽  
Erika Tóth ◽  
Erzsébet Csernák ◽  
Katalin Purcsi ◽  
...  
Keyword(s):  
Case Report ◽  
Granulosa Cell ◽  
Ovarian Tumor ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Review Of The Literature ◽  
Adult Type ◽  
Histologic Subtype ◽  
Brenner Tumor

A combination of ovarian tumors with the same histogenetic origin but different histologic subtype is relatively common, whereas a co-occurrence of tumors with different histogenetic origin is rare. We report a case of mixed ovarian tumor composed of Brenner tumor and adult-type granulosa cell tumor, a combination that to the best of our knowledge has not been reported in the literature until now.

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