scholarly journals Castleman’s disease associated with mixed connective tissue disorder and cerebral ischaemia and vasculitis: A rare case and a diagnostic challenge for an infectologist

2020 ◽  
Vol 77 (8) ◽  
pp. 872-877
Author(s):  
Lidija Popovic-Dragonjic ◽  
Maja Jovanovic ◽  
Miodrag Vrbic ◽  
Maja Stanojevic ◽  
Miljan Krstic ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Connective Tissue ◽  
Castleman’S Disease ◽  
Connective Tissue Disorder ◽  
Castleman's Disease ◽  
Diagnostic Challenge ◽  
Systemic Involvement ◽  
Similar Appearance ◽  
Mixed Connective Tissue Disorder

Introduction. Castleman's disease (CD) or angiofolicullar lymph node hyperplasia is a rare pathologic process characterized by non-neoplastic reactive proliferation of lymphoid tissue. Mimicking clinical and laboratory signs of infection, it could be a great diagnostic problem for an infectologist. Case report. We report a case of a 39-year old man who was initially clinically suspected to have an infectious central nervous system (CNS) affection, having most similar appearance to neurotuberculosis. Malignancy with bone metastases and lymphoma were also among many possible diagnoses. The patient was later histologically confirmed to have Castleman's disease, analyzing the enlarged inguinal lymph node, which was the key point in rejecting the suspicion of malignancy and tuberculosis. By further analyses, the patient was diagnosed to have mixed connective tissue disorder (MCTD). Vasculitis of mesencephalon and thalamus was detected by magnetic resonance imaging. Conclusion. CD with CNS involvement is very rare as well as CD with MCTD association, making this case even more unique. This case report underlines the importance of definitive histological diagnosis in patients with lymphadenopathia associated with systemic involvement and the need of additional immunological and radiological examinations, as well.

Castleman's disease (giant lymph node hyperplasia) of the neck: a case report

2001 ◽  
Vol 258 (1) ◽  
pp. 42-44 ◽  
Author(s):  
Ü. Osma ◽  
Sebahattin Cureoglu ◽  
Mehmet Yaldiz ◽  
Ismail Topcu
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Giant Lymph Node Hyperplasia ◽  
Lymph Node Hyperplasia

scholarly journals Distal Renal Tubular Acidosis as complication of Mixed Connective Tissue Disorder with autoimmune hypothyroidism- a case report

2016 ◽  
Vol 27 (1) ◽  
pp. 37-39
Author(s):  
Md Daharul Islam ◽  
SM Tajdit Rahman ◽  
Khaleda Akter ◽  
Md Azizul Hoque
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Renal Tubular Acidosis ◽  
Connective Tissue Disorder ◽  
Distal Renal Tubular Acidosis ◽  
Undifferentiated Connective Tissue Disease ◽  
Acid Transport ◽  
Autoimmune Hypothyroidism ◽  
Renal Tubular ◽  
Mixed Connective Tissue Disorder

Renal tubular acidosis (RTA) is a constellation of syndromes arising from different derangements of tubular acid transport. Multiple associations have been established with renal tubular acidosis. We report a case of distal renal tubular acidosis which may be associated with undifferentiated connective tissue disease in which patient is also having autoimmune hypothyroidism along with that is not very common.Bangladesh J Medicine Jan 2016; 27(1) : 37-39

scholarly journals Autoamputation and Polyneuropathy in Mixed Connective Tissue Disorder: A Case Report

Cureus ◽  
2017 ◽  
Author(s):  
Syeda Naqvi ◽  
Vikash Talib ◽  
Razia Aijaz ◽  
Zeeshan Ali ◽  
Shehroz Bashir ◽  
...  
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Connective Tissue Disorder ◽  
Mixed Connective Tissue Disorder

scholarly journals Retroperitoneal unicentric Castleman's disease (giant lymph node hyperplasia): case report

2007 ◽  
Vol 125 (4) ◽  
pp. 253-255 ◽  
Author(s):  
Jaques Waisberg ◽  
Marie Satake ◽  
Nagamassa Yamagushi ◽  
Leandro Luongo de Matos ◽  
Daniel Reis Waisberg ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Left Kidney ◽  
White Male ◽  
Castleman’S Disease ◽  
Cardiac Insufficiency ◽  
Castleman's Disease ◽  
Giant Lymph Node Hyperplasia ◽  
Renal Hilus ◽  
Lymph Node Hyperplasia

CONTEXT AND OBJECTIVE: Castleman's disease, or giant lymph node hyperplasia, is a rare disorder of the lymphoid tissue that causes lymph node enlargement. It is considered benign in its localized form, but aggressive in the multicentric type. The definitive diagnosis is based on postoperative pathological findings. The aim here was to describe a case of retroperitoneal unicentric Castleman's disease in the retroperitoneum. CASE REPORT: A 61-year old white male with weight loss and listlessness presented with moderate arterial hypertension and leukopenia. Abdominal tomography revealed a 5 x 4 x 5 cm oval mass of low attenuation, with inner calcification and intense enhancement on intravenous contrast, located in the retroperitoneal region, between the left kidney and the aorta, at the renal hilus. Exploratory laparotomy revealed a non-pulsatile solid oval mass situated in the retroperitoneum, adjacent to the left renal hilus. The retroperitoneal lesion was removed in its entirety. Examination of frozen samples revealed benign lymph node tissue and histopathological examination of the surgical sample revealed hyaline-vascular giant lymph node hyperplasia (Castleman's disease). The patient was discharged on the 12th day without significant events. Two months after the operation, the patient was readmitted with severe cardiac insufficiency, acute renal failure and bronchopneumonia, which progressed to acute respiratory insufficiency, sepsis and death.

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