548-P: Early Liver Dysfunction Predicts Cardiac Autonomic Neuropathy in Adolescents with Type 1 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 548-P
Author(s):  
VALLIMAYIL VELAYUTHAM ◽  
PAUL Z. BENITEZ-AGUIRRE ◽  
MARIA E. CRAIG ◽  
JANINE CUSUMANO ◽  
GERALD LIEW ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autonomic Neuropathy ◽  
Liver Dysfunction ◽  
Cardiac Autonomic Neuropathy

scholarly journals Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes

2019 ◽  
Vol 16 (3) ◽  
pp. 297-299 ◽  
Author(s):  
Sharon Nina Admoni ◽  
Daniele Pereira Santos-Bezerra ◽  
Ricardo Vesoni Perez ◽  
Thiago Andrade Patente ◽  
Maria Beatriz Monteiro ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glutathione Peroxidase ◽  
Autonomic Neuropathy ◽  
Microvascular Complications ◽  
Diabetic Complication ◽  
Cardiac Autonomic Neuropathy ◽  
Inverse Association ◽  
Gene Encoding ◽  
Functional Variant

Cardiac autonomic neuropathy is a neglected diabetic chronic complication for which genetic predictors are rarely reported. Oxidative stress is implicated in the pathogenesis of microvascular complications, and glutathione peroxidase 4 is involved in the detoxification of peroxides and of reactive oxygen species. Thus, the association of a functional variant in the gene encoding glutathione peroxidase 4 (rs713041) with this diabetic complication was investigated in 341 individuals with type 1 diabetes evaluated for cardiac autonomic neuropathy status (61.7% women, 34 [27–42] years old; diabetes duration: 21 [15–27] years; HbA1c: 8.3% [7.4–9.4]; as median [interquartile interval]). Cardiac autonomic neuropathy was present in 29% of the participants. There was an inverse association of the minor T allele of rs713041 with cardiac autonomic neuropathy (odds ratio = 0.39; 95% confidence interval = 0.17–0.90; p  = 0.0271) after adjustment for potential confounders. The functional glutathione peroxidase 4 variant rs713041 modulated the risk for cardiac autonomic neuropathy in the studied population with type 1 diabetes.

scholarly journals The haptoglobin 2-2 genotype is associated with cardiac autonomic neuropathy in type 1 diabetes: the RETRO HDLc study

2019 ◽  
Vol 57 (3) ◽  
pp. 271-278
Author(s):  
Jinghui Ju ◽  
Erin L. Tomaszewski ◽  
Trevor J. Orchard ◽  
Rhobert W. Evans ◽  
Eleanor Feingold ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy

scholarly journals Genetic variants inDNMT1and the risk of cardiac autonomic neuropathy in women with type 1 diabetes

2019 ◽  
Vol 10 (4) ◽  
pp. 985-989 ◽  
Author(s):  
Daniele Pereira Santos‐Bezerra ◽  
Sharon Nina Admoni ◽  
Rosana Cristina Mori ◽  
Tatiana Souza Pelaes ◽  
Ricardo Vesoni Perez ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autonomic Neuropathy ◽  
Genetic Variants ◽  
Cardiac Autonomic Neuropathy

scholarly journals Identification and performance of multiple clinical and laboratorial risk factors for diagnosis of cardiac autonomic neuropathy in type 1 diabetes patients

2019 ◽  
Vol 18 (2) ◽  
pp. 565-573
Author(s):  
Cinthia Minatel Riguetto ◽  
Caroline Rigoleto Takano ◽  
Sharon Nina Admoni ◽  
Maria Candida Ribeiro Parisi ◽  
Maria Lucia Correa Giannella ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
And Performance ◽  
Diabetes Patients
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