Insulin and Growth Hormone Secretion in Rats with Ventromedial Hypothalamic Lesions Maintained on Restricted Food Intake

Diabetes ◽  
1974 ◽  
Vol 23 (3) ◽  
pp. 203-208 ◽  
Author(s):  
J. M. Martin ◽  
W. Konijnendijk ◽  
P. R. Bouman
2008 ◽  
Vol 20 (10) ◽  
pp. 1138-1146 ◽  
Author(s):  
D. Grouselle ◽  
E. Chaillou ◽  
A. Caraty ◽  
M.-T. Bluet-Pajot ◽  
P. Zizzari ◽  
...  

2007 ◽  
Vol 39 (Supplement) ◽  
pp. S488-S489
Author(s):  
Koji Toshinai ◽  
Muhtashan S. Mondal ◽  
Takuya Shimbara ◽  
Hideki Yamaguchi ◽  
Yukari Date ◽  
...  

2007 ◽  
Vol 22 (5) ◽  
pp. 1309-1313 ◽  
Author(s):  
O. Alvarez-Garcia ◽  
E. Garcia-Lopez ◽  
J. Rodriguez ◽  
H. Gil-Pena ◽  
I. Molinos ◽  
...  

Peptides ◽  
2005 ◽  
Vol 26 (10) ◽  
pp. 1720-1727 ◽  
Author(s):  
Amanda M. Shaw ◽  
Boman G. Irani ◽  
Marcus C. Moore ◽  
Carrie Haskell-Luevano ◽  
William J. Millard

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Christine Delporte

Ghrelin is the natural ligand of the growth hormone secretagogue receptor (GHS-R1a). Ghrelin is a 28 amino acid peptide possessing a unique acylation on the serine in position 3 catalyzed by ghrelinO-acyltransferase (GOAT). Ghrelin stimulates growth hormone secretion, but also appetite, food intake, weight gain, and gastric emptying. Ghrelin is involved in weight regulation, obesity, type 2 diabetes, and metabolic syndrome. Furthermore, a better understanding of ghrelin biology led to the identification of molecular targets modulating ghrelin levels and/or its biological effects: GOAT, ghrelin, and GHS-R1a. Furthermore, a recent discovery, showing the involvement of bitter taste receptor T2R in ghrelin secretion and/or synthesis and food intake, suggested that T2R could represent an additional interesting molecular target. Several classes of ghrelin-related pharmacological tools for the treatment of obesity have been or could be developed to modulate the identified molecular targets.


2007 ◽  
Vol 128 (2) ◽  
pp. 182-186 ◽  
Author(s):  
K TOSHINAI ◽  
M MONDAL ◽  
T SHIMBARA ◽  
H YAMAGUCHI ◽  
Y DATE ◽  
...  

Endocrinology ◽  
2000 ◽  
Vol 141 (11) ◽  
pp. 4325-4328 ◽  
Author(s):  
A. M. Wren ◽  
C. J. Small ◽  
H. L. Ward ◽  
K. G. Murphy ◽  
C. L. Dakin ◽  
...  

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