Lack of a Major Role of Staphylococcus aureus Panton-Valentine Leukocidin in Lower Respiratory Tract Infection in Nonhuman Primates

Aims: This study was designed to determine the isolates from microbial cultures and the antibiotics susceptibility pattern of adults with lower respiratory tract infection. Study Design: A retrospective study. Place and Duration of Study: This study was carried out at the Pulmonology units of Medicine department and Microbiology research laboratory unit, Microbiology and Parasitology department, University of Abuja Teaching Hospital (UATH) Gwagwalada, Federal Capital Territory (F.C.T) from August 2015 to September 2018 (Thirty-six months). Methodology: This was a retrospective study. patients with LRTI who met the inclusion criteria were reviewed. The data were extracted from patients’ case notes using well-structured tools. The quality of clinical and laboratory work up were verified by the contribution of specialist Pulmonologist and Microbiologist in the management of patients. Results: A total of one hundred and ninety-eight sample were reviewed of which fifty-seven percent (112) were males and the mean age of the study populations was 37± 13.8 years. From the positive cultures 86.9% were bacteremia and 4.0% were fungaemia. Streptococcus pneumoniae (30.3%) was the most predominant bacteria recovered from the sputum specimens; closely followed by Klebsiella pneumoniea and Staphylococcus aureus. imipenem and ofloxacin had good susceptibility activity and bacteria eradication rate with susceptibility rate of 92.8% and 92.5% respectively. Erythromycin, Augmentin and ceftriaxone had susceptibility of 66.2%, 89.4% and 90.0% respectively. Conclusion: Streptococcus pneumonia, Klebsiella pneumoniea and Staphylococcus aureus are the most common bacteria isolated from sputum of patient who presented with LRTI. Quinolone (ofloxacin) and imipinem are the most sensitive antibiotics and should be considered in initiation of empiric antibiotic treatment.

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Lower respiratory tract infection with Staphylococcus aureus in sickle-cell adult patients with severe acute chest syndrome - the STAPHACS Study -

Haematologica ◽

10.3324/haematol.2021.278827 ◽

2021 ◽

Author(s):

Alexandre Elabbadi ◽

Guillaume Voiriot ◽

Anne Tristan ◽

Aude Gibelin ◽

Charlotte Verdet ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Tract Infection ◽

Respiratory Tract ◽

Respiratory Tract Infection ◽

Lower Respiratory Tract Infection ◽

Sickle Cell ◽

Lower Respiratory Tract ◽

Adult Patients ◽

Acute Chest Syndrome

Not available.

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Role of lung ultrasound for the etiological diagnosis of acute lower respiratory tract infection (ALRTI) in children: a prospective study

Journal of Ultrasound ◽

10.1007/s40477-021-00600-z ◽

2021 ◽

Author(s):

Danilo Buonsenso ◽

Annamaria Musolino ◽

Valentina Ferro ◽

Cristina De Rose ◽

Rosa Morello ◽

...

Keyword(s):

Tract Infection ◽

Respiratory Tract ◽

Prospective Study ◽

Respiratory Tract Infection ◽

Lower Respiratory Tract Infection ◽

Lower Respiratory Tract ◽

Lung Ultrasound ◽

Respiratory Pathogens ◽

Etiological Diagnosis

Abstract Objective and design Our prospective study assesses the role of detailed lung ultrasound (LUS) features to discriminate the etiological diagnosis of acute lower respiratory tract infection (ALRTI) in children. Methodology We analyzed patients aged from 1 month to 17 years admitted between March 2018 and April 2020 who were hospitalized for ALRTI. For all patients, history, clinical parameters, microbiological data, and lung ultrasound data were collected. Patients were stratified into three main groups (“bacterial”, “viral”, “atypical”) according to the presumed microbial etiology and LUS findings evaluated according to the etiological group. Nasopharyngeal swabs were obtained from all patients. A qualitative diagnostic test developed by Nurex S.r.l. was used for identification of bacterial and fungal DNA in respiratory samples. The Seegene Allplex™ Respiratory assays were used for the molecular diagnosis of viral respiratory pathogens. In addition, bacterial culture of blood and respiratory samples were performed, when indicated. Results A total of 186 children with suspected ALRTI (44% female) with an average age of 6 were enrolled in the study. We found that some ultrasound findings as size, number and distribution of consolidations, the position and motion of air bronchograms, pleural effusions and distribution of vertical artifacts significantly differ (p < 0.05) in children with bacterial, viral and atypical ALRTI. Conclusion Our study provides a detailed analysis of LUS features able to predict the ALRTI ethology in children. These findings may help the physicians to better manage a child with ALRTI and to offer personalized approach, from diagnosis to treatment and follow-up.

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