Efficiency of local application of a new hygienic agent during treatment of radioreactions of oral mucosa in patients with tumors of head and neck region after the radiation therapy

Abstract Introduction Treatment of inoperable cutaneous squamous cell carcinoma (cSCC) of the head and neck region is still debated. Case report We report an original case of cure of cSCC of the head and neck region with weekly hypofractionated radiation therapy with megavoltage electrons prescribed for locally advanced inoperable disease. Results Weekly hypofractionated radiotherapy assured complete regression and was well-tolerated. Conclusion The real efficacy of this treatment in the therapeutic arsenal remains to be defined. A clinical trial is ongoing to test the use of 8 weekly fractions of 8 Gy hypofractionated RT regimens in non-resectable cSCC cases.

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Systematic Review of Normal Tissue Complication Models Relevant to Standard Fractionation Radiation Therapy of the Head and Neck Region Published After the QUANTEC Reports

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2017.09.041 ◽

2018 ◽

Vol 100 (2) ◽

pp. 391-407 ◽

Cited By ~ 21

Author(s):

N. Patrik Brodin ◽

Rafi Kabarriti ◽

Madhur K. Garg ◽

Chandan Guha ◽

Wolfgang A. Tomé

Keyword(s):

Systematic Review ◽

Radiation Therapy ◽

Head And Neck ◽

Normal Tissue ◽

Neck Region ◽

Head And Neck Region ◽

Standard Fractionation

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Mucosal Melanomas of the Head and Neck: The Role of Postoperative Radiation Therapy

ISRN Oncology ◽

10.5402/2012/785131 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Kunal Saigal ◽

Donald T. Weed ◽

Isildinha M. Reis ◽

Arnold M. Markoe ◽

Aaron H. Wolfson ◽

...

Keyword(s):

Radiation Therapy ◽

Head And Neck ◽

Neck Region ◽

Distant Metastases ◽

Postoperative Radiation ◽

Postoperative Radiation Therapy ◽

Head And Neck Region ◽

Definitive Surgery ◽

The University

Objectives. Mucosal melanomas are rarer than their cutaneous counterparts and are associated with a poorer prognosis. We report the clinical outcomes of patients with mucosal melanomas of the head and neck region generally treated with definitive surgery followed by postoperative radiation therapy (RT). Methods. We reviewed the records of 17 patients treated at the University of Miami in 1990–2007. Patients generally received conventionally fractionated RT regimens to the postoperative bed. Elective nodal RT was not routinely delivered. Eight patients received adjuvant chemotherapy or immunotherapy. Results. Median followup was 35.2 months (range 5–225). As the first site of failure: 3 patients recurred locally, 2 regionally and 2 distantly. All 3 patients who recurred locally had not received RT. Of the 5 locoregional recurrences, 4 were salvaged successfully with multimodality therapy with no evidence of disease at last followup. Overall survival was 64.7% at 2 years and 51.5% at 5 years. Conclusions. Patients with mucosal melanoma of the head and neck are best treated with surgery to achieve negative margins, followed by postoperative RT to optimize local control. Elective nodal irradiation may not be indicated in all cases, as regional failures were not predominant. Distant metastases were fewer when compared to historical data, potentially due to advancements in adjuvant therapies as well as aggressive multi-modality salvage at time of failure.

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