Osteosarcoma with lung metastases

Osteosarcoma is the bone tumor that most commonly affects children and adolescents. Before the introduction of polychemotherapy > 90% of patients with osteosarcoma died from pulmonary metastases. Despite development of new protocols of therapy in 30–40% of patients the disease is recurrent, more than 80% of them detected pulmonary metastasis. In this review we discussed the problems of detection of metastatic lung lesions and current approaches of methods of detection and marking of small sized metastatic lung lesions. An additional option in the treatment of lung metastases is intraoperative isolated lung perfusion, surgical approaches of which were also discussed.