Effect of dietary fats with odd or even numbers of carbon atoms on metabolic response and muscle damage with exercise in Quarter Horse–type horses with type 1 polysaccharide storage myopathy

2010 ◽  
Vol 236 (6) ◽  
pp. 663-663
Author(s):  
Lisa A. Borgia ◽  
Stephanie J. Valberg ◽  
Molly E. McCue ◽  
Joe D. Pagan ◽  
Charles R. Roe
Keyword(s):  
Muscle Damage ◽  
Metabolic Response ◽  
Dietary Fats ◽  
Polysaccharide Storage Myopathy ◽  
Quarter Horse

Additional Insulin for Coping with Fat- and Protein-Rich Meals in Adolescents with Type 1 Diabetes: The Protein Unit

2020 ◽  
Author(s):  
Roland Schweizer ◽  
Susann Herrlich ◽  
Martina Lösch-Binder ◽  
Michaela Glökler ◽  
Magdalena Heimgärtner ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
G Protein ◽  
Insulin Dose ◽  
Dietary Fats ◽  
Target Range ◽  
Pump Therapy ◽  
Glucose Levels ◽  
Protein Rich ◽  
Carbohydrate Unit

Abstract Objective Dietary proteins raise blood glucose levels; dietary fats delay this rise. We sought to assess the insulin amount required to normalize glucose levels after a fat- and protein-rich meal (FPRM). Methods Sixteen adolescents (5 female) with type 1 diabetes (median age: 18.2 years; range: 15.2–24.0; duration: 7.1 years; 2.3–14.3; HbA1c: 7.2%; 6.2–8.3%) were included. FPRM (carbohydrates 57 g; protein 92 g; fat 39 g; fibers 7 g; calories 975 Kcal) was served in the evening, with 20 or 40% extra insulin compared to a standard meal (SM) (carbohydrates 70 g; protein 28 g; fat 19 g; fibers 10 g; calories 579 Kcal) or carbohydrates only. Insulin was administered for patients on intensified insulin therapy or as a 4-hour-delayed bolus for those on pump therapy. The 12-hour post-meal glucose levels were compared between FPRM and SM, with the extra insulin amount calculated based on 100 g proteins as a multiple of the carbohydrate unit. Results Glucose levels (median, mg/dL) 12-hour post-meal with 20% extra insulin vs. 40% vs. insulin dose for SM were 116 vs. 113 vs. 91. Glucose-AUC over 12-hour post-meal with 20% extra insulin vs. 40% vs. insulin dose for SM was 1603 mg/dL/12 h vs. 1527 vs. 1400 (no significance). Glucose levels in the target range with 20% extra insulin vs. 40% were 60% vs. 69% (p=0.1). Glucose levels <60 mg/dL did not increase with 40% extra insulin. This corresponds to the 2.15-fold carbohydrate unit for 100 g protein. Conclusions We recommend administering the same insulin dose given for 1 carbohydrate unit (10 g carbs) to cover 50 g protein.

Developmental Onset of Polysaccharide Storage Myopathy in 4 Quarter Horse Foals

2002 ◽  
Vol 16 (5) ◽  
pp. 581 ◽  
Author(s):  
Flavio D. De La Corte ◽  
Stephanie J. Valberg ◽  
Jennifer M. MacLeay ◽  
James R. Mickelson
Keyword(s):  
Polysaccharide Storage Myopathy ◽  
Quarter Horse

Effect of Diet on Haflinger Horses With GYS1 Mutation (Polysaccharide Storage Myopathy Type 1)

2015 ◽  
Vol 35 (7) ◽  
pp. 598-605 ◽  
Author(s):  
Ulrike Schröder ◽  
Theresia F. Licka ◽  
Rebeka Zsoldos ◽  
Caroline N. Hahn ◽  
Neil MacIntyre ◽  
...  
Keyword(s):  
Polysaccharide Storage Myopathy

scholarly journals Evaluation of Cardiac Phenotype in Horses with Type 1 Polysaccharide Storage Myopathy

2012 ◽  
Vol 26 (6) ◽  
pp. 1464-1469 ◽  
Author(s):  
R.J. Naylor ◽  
V. Luis-Fuentes ◽  
L. Livesey ◽  
C.B. Mobley ◽  
N. Henke ◽  
...  
Keyword(s):  
Cardiac Phenotype ◽  
Polysaccharide Storage Myopathy

Presence of the glycogen synthase 1 (GYS1) mutation causing type 1 polysaccharide storage myopathy in continental European draught horse breeds

2010 ◽  
Vol 167 (20) ◽  
pp. 781-784 ◽  
Author(s):  
J. D. Baird ◽  
S. J. Valberg ◽  
S. M. Anderson ◽  
M. E. McCue ◽  
J. R. Mickelson
Keyword(s):  
Glycogen Synthase ◽  
Polysaccharide Storage Myopathy

Muscle damage alters the metabolic response to dynamic exercise in humans: a31P-MRS study

2011 ◽  
Vol 111 (3) ◽  
pp. 782-790 ◽  
Author(s):  
Rosemary C. Davies ◽  
Roger G. Eston ◽  
Jonathan Fulford ◽  
Ann V. Rowlands ◽  
Andrew M. Jones
Keyword(s):  
Muscle Damage ◽  
Exercise Tolerance ◽  
Metabolic Response ◽  
Peak Torque ◽  
Creatine Kinase Activity ◽  
Dynamic Exercise ◽  
Incremental Exercise ◽  
Whole Body ◽  
Time To Exhaustion ◽  
Resonance Spectroscopy

We used31P-magnetic resonance spectroscopy to test the hypothesis that exercise-induced muscle damage (EIMD) alters the muscle metabolic response to dynamic exercise, and that this contributes to the observed reduction in exercise tolerance following EIMD in humans. Ten healthy, physically active men performed incremental knee extensor exercise inside the bore of a whole body 1.5-T superconducting magnet before (pre) and 48 h after (post) performing 100 squats with a load corresponding to 70% of body mass. There were significant changes in all markers of muscle damage [perceived muscle soreness, creatine kinase activity (434% increase at 24 h), and isokinetic peak torque (16% decrease at 24 h)] following eccentric exercise. Muscle phosphocreatine concentration ([PCr]) and pH values during incremental exercise were not different pre- and post-EIMD ( P > 0.05). However, resting inorganic phosphate concentration ([Pi]; pre: 4.7 ± 0.8; post: 6.7 ± 1.7 mM; P < 0.01) and, consequently, [Pi]/[PCr] values (pre: 0.12 ± 0.02; post: 0.18 ± 0.05; P < 0.01) were significantly elevated following EIMD. These mean differences were maintained during incremental exercise ( P < 0.05). Time to exhaustion was significantly reduced following EIMD (519 ± 56 and 459 ± 63 s, pre- and post-EIMD, respectively, P < 0.001). End-exercise pH (pre: 6.75 ± 0.04; post: 6.83 ± 0.04; P < 0.05) and [PCr] (pre: 7.2 ± 1.7; post: 14.5 ± 2.1 mM; P < 0.01) were higher, but end-exercise [Pi] was not significantly different (pre: 19.7 ± 1.9; post: 21.1 ± 2.6 mM, P > 0.05) following EIMD. The results indicate that alterations in phosphate metabolism, specifically the elevated [Pi] at rest and throughout exercise, may contribute to the reduced exercise tolerance observed following EIMD.

scholarly journals Developmental Onset of Polysaccharide Storage Myopathy in 4 Quarter Horse Foals

2002 ◽  
Vol 16 (5) ◽  
pp. 581-587 ◽  
Author(s):  
Flavio D. Corte ◽  
Stephanie J. Valberg ◽  
Jennifer M. MacLeay ◽  
James R. Mickelson
Keyword(s):  
Polysaccharide Storage Myopathy ◽  
Quarter Horse

Expression and Regulation of Glycogen Synthase in Equine Type 1 Polysaccharide Storage Myopathy

2014 ◽  
Vol 46 ◽  
pp. 28-28
Author(s):  
C Maile ◽  
J Hingst ◽  
J Wojtaszewski ◽  
R Piercy
Keyword(s):  
Glycogen Synthase ◽  
Polysaccharide Storage Myopathy

Polysaccharide storage myopathy phenotype in quarter horse-related breeds is modified by the presence of an RYR1 mutation

2009 ◽  
Vol 19 (1) ◽  
pp. 37-43 ◽  
Author(s):  
M.E. McCue ◽  
S.J. Valberg ◽  
M. Jackson ◽  
L. Borgia ◽  
M. Lucio ◽  
...  
Keyword(s):  
Polysaccharide Storage Myopathy ◽  
Quarter Horse
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