The structural integrity assessment of a nuclear Reactor Pressure Vessel (RPV) during accidental conditions, such as loss-of-coolant accident (LOCA), is a major safety concern. Besides Conventional deterministic calculations to justify the RPV integrity, Electricite´ de France (EDF) carries out probabilistic analyses. Since in the USA the probabilistic fracture mechanics analyses are accepted by the Nuclear Regulatory Commission (NRC), a benchmark has been realized between EDF and Oak Ridge Structural Assessments, Inc. (ORSA) to compare the models and the computational methodologies used in respective deterministic and probabilistic fracture mechanics analyses. Six cases involving two distinct transients imposed on RPVs containing specific flaw configurations (two axial subclad, two circumferential surface-breaking, and two axial surface-braking flaw configurations) were defined for a French vessel. In two separate phases, deterministic and probabilistic, fracture mechanics analyses were performed for these six cases.