Role of microperimetry in evaluating disease progression in age-related macular degeneration: a scoping review

Purpose Recent research has found variable evidence on the role of mesopic and dark-adapted scotopic microperimetry assessment in age-related macular degeneration. This scoping review summarises how mesopic and scotopic microperimetry can be used to assess disease progression in age-related macular degeneration and identifies gaps in the literature. Methods A population, concept, and context approach was used to develop the search strategy. Ovid MEDLINE, EMBASE, Cochrane Library, PubMed, CINAHL Plus, Web of Science, and SCOPUS databases were used to conduct the literature search. The key search terms used in the databases were age-related macular degeneration and microperimetry. Results Twelve studies were eligible and included in the review. All the studies (n = 12) were conducted in European countries [Germany (9), Italy (2), and the United Kingdom (1)]. The mesopic and scotopic sensitivities were measured using the Nidek scotopic microperimeter (MP1-S) (n = 6), scotopic Macular Integrity Assessment device (S-MAIA) (n = 5), and both MP1-s and S MAIA (n = 1). 83.3% (n = 10) studied (cross-sectional design) on mesopic, scotopic microperimetry and found reduced rod (scotopic) photoreceptors sensitivities compared to cone (mesopic) photoreceptors sensitivities in patients with small and reticular pseudodrusen despite having good visual acuity. Only 16.7% (n = 2) of studies followed participants with reticular drusen/large drusen for three years (longitudinal design) and found reduced scotopic over mesopic sensitivity at baseline and localized mesopic with profound scotopic sensitivity loss during follow-ups. Conclusion Scotopic sensitivity is a better functional indicator than mesopic sensitivity to understand early and intermediate age-related macular degeneration progression. The evidence from longitudinal studies is debatable due to the limited stimuli range of existing microperimeters, smaller sample size, and lost follow-ups.

Integrity Assessment of Pipelines Failures

The proactive maintenance of pipelines through condition based monitoring, plays an essential role in improving their overall reliability and availability. Their criticality can also be assessed by conducting reliability analysis such as FMECA, which helps in identifying relevant failure modes and averting catastrophic failures to sustain economic growth. This paper will focus on an integrity assessment set up for pipelines and the potential failure modes associated are evaluated and mitigated by determining the risk triggers. The outcome of this research has shown the various threats associated with pipelines, having an effective integrity assessment program will help mitigate such threats. Keywords: Risk Assessment, Corrosion, FMECA, Risk Priority, Failure, Inspection, Regulations, Pipelines, Monitoring

A baseline-free method for damage identification in pipes from local vibration mode pair frequencies

As structural systems approach their end of service life, integrity assessment and condition monitoring during late life becomes necessary in order to identify damage due to age-related issues such as corrosion and fatigue and hence prevent failure. In this paper, a novel method of level 3 damage identification (i.e. detection, localisation and quantification) from local vibration mode pair (LVMP) frequencies is introduced. Detection is achieved by observation of LVMP frequencies within any of the vibration modes investigated while the location of the damage is predicted based on the ranking order of the LVMP frequency ratios and the damage is quantified in terms of material volume loss from pre-established quantification relations. The proposed method which is baseline-free (in the sense that it does not require vibration-based assessment or modal data from the undamaged state of the pipe) and solely frequency-dependent was found to be more than 90% accurate in detecting, locating and quantifying damage through a numerical verification study. It was also successfully assessed using experimental modal data obtained from laboratory tests performed on an aluminium pipe with artificially inflicted corrosion-like damage underscoring a novel concept in vibration-based damage identification for pipes.

High-Temperature Tensile and Creep Behavior in a CrMoV Steel and Weld Metal

The 2.25Cr1Mo0.25V steel is a vanadium-modified 2.25Cr1Mo steel and is being widely used in the manufacture of heavy-wall hydrogenation reactors in petrochemical plants. However, the harsh service environment requires a thorough understanding of high-temperature tensile and creep behaviors of 2.25Cr1Mo0.25V steel and its weld for ensuring the safety and reliability of hydrogenation reactors. In this work, the high-temperature tensile and creep behaviors of base metal (BM) and weld metal (WM) in a 2.25Cr1Mo0.25V steel weldment used for a hydrogenation reactor were studied experimentally, paying special attention to its service temperature range of 350–500 °C. The uniaxial tensile tests under different temperatures show that the WM has higher strength and lower ductility than those of BM, due to the finer grain size in the WM. At the same time, the short-term creep tests at 550 °C reveal that the WM has a higher creep resistance than that of BM. Moreover, the creep damage mechanisms were clarified by observing the fracture surface and microstructures of crept specimens with the aid of scanning electron microscopy (SEM). The results showed that the creep damage mechanisms of both BM and WM are the initiation and growth of creep cavities at the second phase particles. Results from this work indicate that the mismatch in the high-temperature tensile strength, ductility, and creep deformation rate in 2.25Cr1Mo0.25V steel weldment needs to be considered for the design and integrity assessment of hydrogenation reactors.

Operational failure assessment of Remotely Operated Vehicle (ROV) in harsh offshore environments

For an effective integrity assessment of marine robotic in offshore environments, the elements’ failure characteristics need to be understood. A structured probabilistic methodology is proposed for the operational failure assessment (OFA) characteristics of ROV. The first step is to assess the likely failure mode of the ROV system and its support systems. This captures the interaction and failure induced events during operation. The identified potential failure modes are further developed into logical connectivity based on the cause-effect relationship. The logical framework is modeled using the fault tree analysis technique to predict the ROV operational failure probability in an uncertain harsh environment. The fault tree analysis captured the logical relationship between the primary, intermediate, and top events probability. The importance measure criteria were adopted to identify the most probable events, links, and their importance on the failure propagation. The model was demonstrated with an ROV for deep arctic water subsea operations. The result identified the control system, communication linkages, human factor, among others, as most critical in the ROV operational failure. The methodology’s application provides core information on the Mean time between failure (MTBF) of the ROV system that could aid integrity management and provides a guide on early remedial action against total failure.

Fracture Assessment for Pressurized Water Reactor Vessel Nozzles Subjected to Pressure and Thermal Loading

To ensure the structure integrity of the RPV, the main challenge is the embrittlement of beltline material. However, the stress of inlet or outlet nozzles of the RPV which are in general reinforced in comparison with the beltline, is more complex especially under the thermal loads. In recently studies, a lot of works have been done to show that the nozzle region may be more challenging under some conditions. In this paper, a fracture assessment for the RPV nozzles subjected to pressure and thermal loading is discussed using the software ABAQUS 6.12 and Zen Crack 7.9-3. It includes: SIF calculation based on 3D finite element method; structural integrity assessment under a typical LOCA transient; and the fatigue crack growth evaluation under cyclic loading situations. The results show that the SIF along the crack front is obviously asymmetric, and only to assess the safety of the deepest point along the crack front in the ASME and RCC-MR codes may be reconsider. If the KIa criteria is applied, under a typical LOCA transient, it is difficult to obtain an effective fracture safety margin for a 1/4 thickness crack, while based on the KIC criteria, the nozzle is shown to be safe in the case study. The shape of the surface elongated crack (which is often easily produced in the nozzle area) tends to be circle under the cyclic pressure loading situation which shows the crack shape assumed in the ASME and RCC-MR codes is reasonable.

Optimized Inspection and Integrity Assessment of Well Conductors for Life Extension Strategic Planning

Assuring integrity of offshore well Conductor is one of the challenges in the aged giant offshore fields operating with 1500+ wells. Such fields should have a robust and efficient integrity management system for inspection and assessment of well conductors through the well life cycle. Offshore well Conductors form the secondary load-bearing element in a well, primary being the surface casing. A practical approach in assessing the structural integrity of the well conductor is proposed in this paper. Wells were classifying into five subgroups; optimized Inspection and Integrity Assessment methods used to establish the structural integrity of conductors; which were evaluated and validated by a 3rd part consultant. The assessment results indicate how over-conservative assumptions in engineering assessment may mislead operators to categorize wells into higher risk. Assessment was performed utilizing various modeling software. Reliability based approach was adopted to accommodate uncertainties in data utilizing appropriate engineering judgement to tackle data gaps. Average thickness measured at discrete elevations was compared with the calculated minimum required thickness (MRT) to assess the structural integrity status of conductors. This approach helped in the decision making and planning for risk mitigation repairs. The results of optimized inspection techniques and structural assessment methodology lead to establishment of clear pattern for critical well conductors and applied to the groups to decide on maintenance strategy. The conductor wall thickness data measured from automated thickness measurement technique is matching with the measured data from manual thickness measurements. The average wall thickness at each elevation, obtained from the raw automated thickness measurement technique data to be used for assessment of the conductor. After building good confidence in the mode of failure the results indicated that manual thickness measurement technique is sufficient to assess the structural integrity of the conductors. The consultant has performed parametric studies to validate the Minimum Required Thickness (MRT) for the most onerous well in the group; by modelling the boundary conditions of conductor span between the guides, the critical water depth, well depth etc. Sensitivity studies were performed considering the environmental loading due to wind, wave, current; vortex induced vibrations, cement height behind the pipes etc. From the new findings the integrity status of the current wells risk ranking will be reviewed and if the average measured thickness is greater than the MRT then a repair program is no more required. The resource utilization was optimized based on the final outcome of the exercise. A procedure based optimized inspection techniques and structural integrity assessments to the group the well conductors resulted in the revision of risk ranking of wells, efficient maintenance planning and achieve high-cost optimization for its life extension. The outcome of the consultancy study will also substantiate our current method of conductor assessment and decision for repair based on risk-based approach. Based on the learnings this paper will be focusing on utilizing optimal inspection and assessment approach.

Rapid Ecological Integrity Assessment Metrics to Restore Wildlife Habitat and Biodiversity for Shortleaf Pine–Oak Ecosystems

Open woodlands dominated by shortleaf pine (Pinus echinata Mill.) and oak are historically an important component of the landscape across the southeastern United States. These ecosystems support numerous wildlife species, many of which have declined in recent years as the amount and condition of their habitat have declined. Land managers and private landowners need guidance on how to efficiently and accurately quantify the condition and wildlife habitat value of the pine stands that they manage. Here we provide a set of rapid assessment metrics, based on NatureServe’s ecological integrity assessment (EIA) method, to (a) identify exemplary tracts that provide the best habitat for key wildlife species, and (b) monitor restoration efforts to assess progress toward the improved quality of existing tracts. To ensure an ecologically appropriate scaling of metrics, we distinguished six types of shortleaf pine–oak woodland: A.—Interior Highlands shortleaf pine–oak (including A.1—shortleaf pine–oak forest and woodlands; A.2—shortleaf pine–bluestem woodlands); B—montane longleaf pine–shortleaf pine woodlands; C—southern Appalachian pine–oak woodlands; D—West Gulf coastal plain shortleaf pine–oak woodlands; and E—southeast coastal plain and Piedmont shortleaf pine–oak woodlands. We relied on a narrative conceptual model and peer review-based indicator selection to identify a core set of 15 stand-level metrics (two were optional). Individual assessment points (thresholds) and ratings (Excellent, Good, Fair, and Poor) were developed that were sensitive to the distinct attributes of each of the five shortleaf pine–oak and Appalachian pine–oak types. Values for the metrics can all be collected using rapid field methods, such as using basal area prisms and ocular (visual) estimates of cover. Protocols for the consistent application of these EIA methods are provided. A case study is presented from the Cherokee National Forest in Tennessee. These methods provide improved and rapid EIA metrics for all shortleaf pine–oak ecosystems in the southeastern US to help guide conservation-minded landowners in assessing the biodiversity and priority wildlife values of shortleaf pine–oak and southern Appalachian pine–oak ecosystems.