Kinetic of monocytes Fcγ receptors in patients after coronary artery bypass

Open Medicine ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. 31-36
Author(s):  
Hristina Andreeva ◽  
Steinar Lundemoen ◽  
Godfrid Greve ◽  
Rune Haaverstad ◽  
Gustav Fjaertoft
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Surface Expression ◽  
Fc Gamma Receptors ◽  
Increased Risk ◽  
Cd16 Expression ◽  
Baseline Values ◽  
Pump Coronary Artery Bypass

AbstractCardiopulmonary bypass is usually associated with an increased risk of post-operative infections and systemic inflammatory response syndrome. This is accompanied by a neutrophil leucocytosis and lymphopenia. Less is known about the role of monocytes and markers of monocyte activity. This study focuses on the changes of Fc-gamma receptors on monocytes in patients undergoing on-pump coronary artery bypass grafting (CABG).The surface expression of CD64, CD32 and CD16 were studied using flow cytometry in 37 patients scheduled for CABG. The antigen density and the percentage positive cells were monitored preoperatively and on day 1, 2, 3 and 7 postoperatively. CD64 and CD32 antigen density were significantly increased from day 1 to day 7(p<0.0001). A significant increase (p<0.0001) in the percentage CD16+ monocytes was detected at day 1,2,and 3. The downregulation of CD16 expression on day 1 was followed be elevation at days 2,3(p<0.01). On day 7th percentage CD16+ monocytes and density were not returned to baseline values. Only the baseline levels of CD64 was lower compared to controls(p<0.05). The results suggest that on-pump CABG induces dynamic changes in the expression of Fc-gamma receptors on monocytes as late as 7 days. We observed significant upregulation in the expression of CD64 and CD32 and “to phases” distribution of CD16 in the post-CABG period.

scholarly journals Role of Off-Pump Coronary Artery Bypass Grafting in Patients With Malignant Neoplastic Disease

2000 ◽  
Vol 64 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Masami Ochi ◽  
Kenichi Yamada ◽  
Masahiro Fujii ◽  
Naoko Ohkubo ◽  
Hidetsugu Ogasawara ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Neoplastic Disease ◽  
Bypass Grafting ◽  
Artery Bypass Grafting ◽  
Off Pump ◽  
Pump Coronary Artery Bypass

scholarly journals Perioperative Dynamics of TLR2, TLR4, and TREM-1 Expression in Monocyte Subpopulations in the Setting of On-Pump Coronary Artery Bypass Surgery

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
A. S. Golovkin ◽  
V. G. Matveeva ◽  
I. V. Kudryavtsev ◽  
M. N. Chernova ◽  
Y. V. Bayrakova ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Inflammatory Response ◽  
Coronary Artery Bypass ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Surface Expression ◽  
Inflammatory Phase ◽  
Monocyte Subpopulations ◽  
Pump Coronary Artery Bypass

Hypercytokinemia plays a key role in the pathogenesis of systemic inflammatory response syndrome (SIRS). Monocytes are the main source of cytokines in the early inflammatory phase. Simultaneous stimulation of toll-like receptors (TLRs) and triggering receptor expressed on myeloid cells (TREM-1) activating receptor on monocytes results in the amplification of the inflammatory signal and multiple increase in proinflammatory cytokine production. The dynamics of those receptors expression on monocyte surface of patients with uncomplicated SIRS course followed coronary artery bypass surgery (CABG) was studied. The increase in TLR2 and TREM-1 expression on the first day after CABG induces proinflammatory and amplification potentials of monocytes in that period. The decrease in TLR2 surface expression on the seventh day compared to the preoperative values can be regarded as a mechanism limiting inflammatory response. The highest level of TLR2, TLR4, and TREM-1 surface expression was observed in CD14hiCD16+ monocyte subpopulation, confirming its proinflammatory profile.

Risk Stratification in Off-Pump Coronary Artery Bypass (OPCAB) Surgery—Role of EuroSCORE II

2015 ◽  
Vol 29 (5) ◽  
pp. 1167-1171 ◽  
Author(s):  
Deepak Borde ◽  
Balaji Asegaonkar ◽  
Pramod Apsingekar ◽  
Sujeet Khade ◽  
Savani Futane ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Risk Stratification ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Off Pump ◽  
Opcab Surgery ◽  
Pump Coronary Artery Bypass

scholarly journals Tranexamic acid and convulsive seizures after isolated coronary artery bypass surgery: the role of cardiopulmonary bypass and renal function

2020 ◽  
Vol 30 (4) ◽  
pp. 538-540
Author(s):  
Nikolai Hulde ◽  
Armin Zittermann ◽  
Marcus-Andre Deutsch ◽  
Vera von Dossow ◽  
Jan F Gummert ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Coronary Artery ◽  
Tranexamic Acid ◽  
Coronary Artery Bypass ◽  
Coronary Artery Bypass Surgery ◽  
Artery Bypass ◽  
Cabg Surgery ◽  
Increased Risk ◽  
Convulsive Seizures

Abstract In cardiac surgical patients, tranexamic acid (TXA) has been associated with an increased risk of convulsive seizure (CS). We aimed to investigate whether in patients undergoing isolated coronary artery bypass grafting (CABG) surgery the use of cardiopulmonary bypass (CPB) impacts the risk of CS. We studied 4198 propensity score matched patients. Patients who underwent CABG surgery without CPB, received a single bolus of 1 g TXA. Patients who underwent CABG with CPB, additionally received a TXA dose of 0.5 g in the CPB prime and an infusion of 0.2 g/h until the end of CPB. The risk of CS in the CPB group and the group without CPB was 0.7% and 0.6%, respectively (risk ratio 1.08, 95% confidence interval 0.51–2.30; P &gt; 0.99). Kidney function was significantly associated with the risk of CS (P = 0.005), the latter being highest in patients with glomerular filtration rates &lt;30 ml/min/1.73 m2 (2.2%) and lowest in those patients with values &gt;60 ml/min/1.73 m2 (0.4%). Our data in patients undergoing isolated CABG indicate no significant effect on CS risk by use of CPB when TXA doses of up to ∼2 g are given. However, caution regarding TXA administration is necessary in patients with renal impairment.

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