Perchloric acid catalyzed condensation of amine and aldehydes: Synthesis and antibacterial activities of some aryl (E)-imines

AbstractA series of Schiff’s bases (aryl E-imines) have been derived from the perchloric acid catalyzed condensation of aryl amines and substituted benzaldehydes. The yield of the Schiff’s bases are more than 80%. The synthesized Schiff’s bases are characterized by their physical constants, analytical and spectroscopical data. The antibacterial activities of these Schiff’s bases have been studied using Bauer-Kirby method.

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Lewis Acid Catalyzed Electrophilic Substitution of Indole with Aldehydes and Schiff's Bases Under Microwave Solvent‐Free Irradiation

Synthetic Communications ◽

10.1081/scc-200028611 ◽

2004 ◽

Vol 34 (17) ◽

pp. 3175-3182 ◽

Cited By ~ 55

Author(s):

Min Xia ◽

Si‐hai Wang ◽

Wei‐bo Yuan

Keyword(s):

Lewis Acid ◽

Electrophilic Substitution ◽

Solvent Free ◽

Schiff’S Bases ◽

Schiff's Bases ◽

Acid Catalyzed

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(E)-N-Substitutedbenzylidene-4-Methoxyanilines as Insect Antifeedants

International Letters of Chemistry Physics and Astronomy ◽

10.18052/www.scipress.com/ilcpa.41.118 ◽

2014 ◽

Vol 41 ◽

pp. 118-123

Author(s):

K. Lakshmanan ◽

K.G. Sekar ◽

V. Sathiyendiran ◽

R. Suresh

Keyword(s):

Spectroscopic Data ◽

Assay Method ◽

Schiff’S Bases ◽

Leaf Discs ◽

Physical Constants ◽

Schiff's Bases ◽

Bio Assay ◽

Insect Antifeedants

Some substituted aryl Schiff’s bases [(E)-N-substitutedbenzylidene-4-methoxyanilines] have been prepared and their purities were checked by their physical constants and spectroscopic data reported earlier. The insect antifeedant activities of these Schiff’s bases have been studied by leaf-discs bio assay method using 4th instar larvae AchoeaJanata L.

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SYNTHESIS OF A NOVEL SERIES OF SCHIFF’S BASES FROM PABA AND PHENYL HYDRAZINE AND EVALUATION OF THEIR ANTIOXIDANT ACTIVITY

EPRA International Journal of Research & Development (IJRD) ◽

10.36713/epra8509 ◽

2021 ◽

pp. 271-273

Author(s):

Yalamanchili Praharsha ◽

Sashmitha Samuel.B

Keyword(s):

Potential Role ◽

Antibacterial Activities ◽

Schiff’S Bases ◽

Phenyl Hydrazine ◽

Efficient Procedure ◽

Schiff's Bases ◽

Anti Oxidant ◽

Antibacterial And Antifungal ◽

Areas Of Interest ◽

Therapeutic Activities

Over the past decade, the synthesis of Schiff’s bases has become one of the main areas of interest in synthetic chemistry. These compounds have gained much attention, owing to their potential role as anti-inflammatory, anthelmintic, analgesic, antibacterial and antifungal agents. Thus, in view of the significance and diverse therapeutic activities of Schiff’s bases we have aimed at a simple and efficient procedure for their synthesis by the reaction of various aldehydes with PABA and phenyl hydrazine and also evaluation of their antibacterial activities. We have been successful in synthesizing various Schiff’s bases and also these compounds have been proved to have effective anti-oxidant activity. KEYWORDS: Schiff’s bases, PABA, Phenyl hydrazine, Aldehydes, Dioxan, Hydrogen peroxide, scavenging activity

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Synthesis, Characterization and Antimicrobial Evaluation of Schiff’s Base and Aryl Aminomethyl Derivatives

International Letters of Chemistry Physics and Astronomy ◽

10.18052/www.scipress.com/ilcpa.64.89 ◽

2016 ◽

Vol 64 ◽

pp. 89-94

Author(s):

N.N. Kansagara ◽

V.R. Dangar ◽

V.R. Shah

Keyword(s):

Selective Reduction ◽

Schiff’S Bases ◽

Schiff’S Base ◽

Chemical Structures ◽

Imine Group ◽

Schiff's Bases ◽

Aminomethyl Derivatives ◽

Aryl Amines ◽

Antimicrobial Evaluation ◽

Antibacterial And Antifungal

Schiff’s bases are obtained on heating an aldehydes with aromatic amine in presence of glacial acetic acid. These are the compounds containing characteristic –HC=N– group. Aryl amino methyl derivatives of heterocyclic compounds to synthesize by selective reduction of schiff’s bases (imine group) with sodiumborohydride in controlled experimental condition. Schiff’s base of N-Aryl-1-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]methanimines & Aryl amines of N-Aryl-1-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]methanamines were prepared. Their chemical structures were confirmed by means of IR, NMR, Mass data and by elemental analysis. All of the synthesized compounds were tested for their antibacterial and antifungal activity.

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Viscoelastic properties of a homologous series of nematic liquid crystalline Schiff's bases

Journal de Physique ◽

10.1051/jphys:019840045080134700 ◽

1984 ◽

Vol 45 (8) ◽

pp. 1347-1360 ◽

Cited By ~ 13

Author(s):

J.P. van der Meulen ◽

R.J.J. Zijlstra

Keyword(s):

Homologous Series ◽

Viscoelastic Properties ◽

Liquid Crystalline ◽

Schiff’S Bases ◽

Schiff's Bases

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Green Synthesis, Characterization, DPPH and Ferrous Ion-chelating (FIC) Activity of Tetrakis-Schiff’s Bases of Terephthalaldehyde

Letters in Drug Design & Discovery ◽

10.2174/1570180815666180531101404 ◽

2019 ◽

Vol 16 (3) ◽

pp. 249-255

Author(s):

Momin Khan ◽

Umar Ali ◽

Anis Ur Rahman ◽

Muhammad Ibrahim ◽

Abdul Hameed ◽

...

Keyword(s):

Antioxidant Activities ◽

Radical Scavenging Activity ◽

Radical Scavenging ◽

Aromatic Aldehydes ◽

Ferrous Ion ◽

Future Research ◽

Scavenging Activity ◽

Schiff’S Bases ◽

Schiff's Bases ◽

Antioxidant Agents

Background: The role of small molecules as antioxidants to prevent the oxidation of other molecules and inhibit them from radical formation is the area of much interest to cure disease especially cancer. Moreover, the antioxidants play important role as stabilizers to prevent oxidation of fuels and lubricants. Methods: In the present study, fifteen tetrakis-Schiff’s bases derivatives (1-15) were synthesized and screened for their antioxidant activities. Compounds 1-15 were synthesized by continuous stirring of reaction mixture of 1,4-bis (hydrazonomethyl)benzene (1 mmol) with various substituted aromatic aldehydes (2 mmol) in distilled water using acetic acid as catalyst at room temperature for 2-10 min. Results: Our present study showed that all compounds are better ferrous ion-chelating agents except compound 1,4-bis((E)-((E)-(3,4-dimethoxybenzylidene)hydrazono)methyl)benzene (6) (IC50 = 329.26 ± 4.75 µM) which has slightly low activity than the standard EDTA (IC50 = 318.40 ± 5.53 μM). In addition, DPPH radical scavenging activity of eleven compounds showed higher activity than the standard. However, remaining four compounds showed comparable radical scavenging activity to the standard DPPH (IC50 = 257.77 ± 4.60 µM). Conclusion: The series of fifteen Schiff’s bases (1-15) were synthesized and evaluated as antioxidants. From both assays, it has been demonstrated that most of the tetrakis-Schiff’s bases have potential to serve as leads for the development of antioxidant agents for future research.

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